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20,252 grants found
Showing 181 – 200 of 20,252 grants
Administrative Core
ADMINISTRATIVE CORE – ABSTRACT To support the mission of the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN) Center as a...
Research Methods, Measures, and Data Management Core
RESEARCH METHODS, MEASURES AND DATA MANAGEMENT CORE – ABSTRACT The Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation Center (ACCERT PN...
Advancing Innovations in Patient Navigation and Implementation Science to Address Structural Racism and Social Determinants of Health
SOCIAL DETERMINANTS OF HEALTH RESEARCH PROJECT – ABSTRACT Cancer is a leading cause of death in Chicago, and Black, Latinx and low-income Chinese communities in Chicago face signif...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation - Community Responsive Projects
COMMUNITY RESPONSIVE PROJECTS – ABSTRACT Community Responsive Projects within the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (A...
The Gut Microbial and Dietary Origins of Cancer Treatment-Related CognitiveImpairment
During chemotherapy, 34% of breast cancer survivors (BCS) experience cancer treatment-related cognitive impairment (CRCI). CRCI degrades memory and executive function as well as qu...
Chemical Approaches to Modulate PAX3-FOXO1 in Fusion-Positive Alveolar Rhabdomyosarcoma
PROJECT SUMMARY/ABSTRACT Fusion-positive alveolar rhabdomyosarcoma (FP-RMS) remains a poorly understood but highly fatal cancer of childhood. The pathognomonic fusion oncoprotein o...
Antigen-targeted activation of Topo1 inhibitors via click chemistry
Abstract Most drugs are administered systemically and spread throughout the body. Due to lack of specificity for the pathological site, high doses are required to achieve effective...
Reducing prostate cancer mortality in African American men by early disease detection using DNA fragmentation profiles and methylated DNA patterns of plasma derived cell free DNA
Project Summary/Abstract: African American (AA) individuals with prostate cancer (PCa) face significantly worse clinical outcome than their European American (EA) counterparts. The...
Remote, Young Adult Lay-Counselor Delivered Behavioral and Digital Intervention for Youth to Promote Vaping Cessation and Prevent Escalation of Tobacco Use
PROJECT SUMMARY/ABSTRACT While tobacco smoking has declined dramatically among adolescents and is now almost rare, the prevalence of electronic nicotine delivery device (ENDS, nico...
Interrogating the role of arachidonic acid metabolism in modulating the tumor immune microenvironment as a novel path to therapeutic intervention
ABSTRACT Cancer has been characterized as a chronic, poorly healing wound where inflammatory and proliferative processes continue unchecked without normal healing and resolution of...
Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model Services
Project Summary/Abstract To conquer cancer, researchers with diverse backgrounds and expertise must work together to discover molecular targets and develop therapeutics. Many inves...
Southeast Center for Health Achievement and Growth in Equity (SEACHANGE) Hub
ABSTRACT The mission of the SouthEAst Center for Health Achievement aNd Growth in Equity (SEACHANGE) Hub is to promote health equity and reduce the burden of disease in underserved...
Time-restricted eating to address cancer-related fatigue among survivors of hematological malignancies
PROJECT SUMMARY Cancer-related fatigue is one of the most common and debilitating toxicities/side effects stemming from cancer and its treatments. Patients who endure hematologic m...
Toxicology (IND-enabling) studies for a novel nerve imaging agent for prostate cancer
ABSTRACT Translational safety studies in novel nerve imaging agent for radical prostatectomies In this two-year proposal, we will complete IND-enabling studies for NerveLight, a ne...
Advancing the commercialization readiness of nanoparticle-based immunotherapy for cancer treatment
Treatment of non-small cell lung cancer (NSCLC) requires a combination of many highly toxic drugs and radiation therapy, yet the 5-year survival rate remains about 18%. Immune chec...
Evaluating a Multilevel Intervention to Increase Colonoscopic Follow-up after Abnormal Stool-based Colorectal Cancer Screening in a Community Safety-Net Setting
Project Summary/Abstract Colorectal cancer (CRC) is the second most common cause of cancer-related mortality in the United States (U.S.). Although several effective prevention and...
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
PROJECT SUMMARY/ABSTRACT Lynch syndrome (LS), the most common inherited cause of colorectal cancer (CRC) affecting ~1.2 million Amer- icans, carries 3-8x higher lifetime CRC risk t...
A Multi-level Intervention to Reduce Total Thyroidectomy Overuse for Low-Risk Cancer
PROJECT SUMMARY The majority of patients with low-risk thyroid cancer undergo total thyroidectomy – the riskiest treatment option. Safer, less invasive alternatives offer patients...
Disparities in Immuno-oncology Outcomes in Detroit (DIODE)
Project Summary This application will address cancer health disparities in Black residents of metropolitan Detroit, specifically evaluating racial differences in genetic regulation...
Administrative Core
Project Summary The overall goals of this P20 application are (1) to identify ancestry-specific genetic regulators of macrophage function and response to anti-HER2 antibody therapy...