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20,252 grants found
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Flow Cytometry Core
PROJECT SUMMARY – Flow Cytometry and Immune Monitoring Shared Resource The mission of the USC Norris Comprehensive Cancer Center (NCCC) Flow Cytometry and Immune Monitoring Shared...
Flow Cytometry Core
PROJECT SUMMARY – Flow Cytometry and Immune Monitoring Shared Resource The mission of the USC Norris Comprehensive Cancer Center (NCCC) Flow Cytometry and Immune Monitoring Shared...
Guidelines for processing and storing liquid biopsy samples for functional assays in research and clinical testing.
PROJECT SUMMARY The World Health Organization predicts that cancer diagnoses will increase to 22 million per year within the next two decades, with a corresponding 70% rise in canc...
Evaluation of the Teal self-collect device for cervical cancer screening
PROJECT SUMMARY Limited access to and insufficient uptake of screening remain persistent barriers to cervical cancer elimination as a public health threat. The Teal Health self-col...
PyroTIMER Technology: Enabling T-Cell Persistence in Immunosuppressive Tumor Microenvironments
Abstract The challenge of effectively treating cancer is further complicated by the limitations of current CAR-T cell therapies, especially when confronted with the immunosuppressi...
Multiplex and multi-omic diagnostic test for bladder cancer recurrence
Following initial diagnosis and treatment, bladder cancer has a high recurrence rate, making it one of the most expensive cancers to treat over a patient’s lifetime. The current st...
Informing Lifestyle Recommendations for Kidney Cancer Survival: Investigating the Role of Dietary Patterns and Physical (In)activity
PROJECT SUMMARY Renal cell carcinoma (RCC) accounts for 4.1% of new cancer cases in the United States (US) – 1 out of every 25 diagnoses – and the number of individuals living with...
Cell State Network-Directed Therapy
ABSTRACT—Cell State Network-Directed Therapy Drug resistance is a significant challenge in cancer therapy and has historically been addressed from “one step behind”, whereby drug(s...
TIME-RESTRICTED FEEDING FOR PANCREATIC CANCER PREVENTION
The overarching goal of this Task Order is to determine the efficacy of time-restricted feeding (TRF) on PanIN prevention in a mouse model of pancreatic cancer and identify efficac...
Overcoming tumor-intrinsic mechanisms of immune evasion to boost systemic response to radiotherapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint blockade has revolutionized the therapeutic landscape of patients with metastatic cancer. However, despite remarkable outcomes in some pa...
Epigenetic aging as a driver of racial disparities in early onset prostate cancer
Prostate cancer (PrCa) shows significant racial disparities, especially impacting African American (AA) men, who have a 1.4 times higher risk of PrCa diagnosis, and a double risk o...
Development of CD4 TCR-engineered T cell immunotherapy in triple-negative breast cancer
Abstract Breast cancer is a leading cause of cancer-related deaths of women in the United States and worldwide. Immunotherapy is a promising approach, but has not proven successful...
Safety and Efficacy Trial of the ColoSeal ICD System for the Treatment of Rectal Cancer Patients
PROJECT SUMMARY/ABSTRACT Ostomy surgery for intestinal diseases are performed in around 130,000 patients annually in the US. Although currently fundamental to colorectal disease ca...
CTO1681 to prevent and mitigate cytokine release syndrome in CAR T-cell recipients
Abstract CytoAgents is developing CTO1681 for the prevention and treatment of cytokine release syndrome (CRS) associated with chimeric antigen receptor (CAR) T-cell therapy. CAR T-...
RaceCAR-M immunotherapy for cancer and beyond
Cellular immunotherapies like Chimeric Antigen Receptor T cells (CAR-T) extend the lives of cancer patients who are otherwise out of options. These therapies represent a leap forwa...
The Caribbean Climate Change Adaptation, Cancer, and Health Disparities Research Center
Project Summary Overall Component Climate change is a threat to human health which impacts each step of the cancer control continuum. Frequent extreme weather events in the US Cari...
Administrative Core
Summary Administrative Core The Administrative Core (AC) of the Caribbean Climate Change Adaptation, Cancer, and Health Disparities Research Center (CCCARIB-CARES) will provide inf...
Research Project
RESEARCH PROJECT SUMMARY Climate change poses risks to human health through direct and indirect stressors. On tropical islands, some of the risks are accentuated. The population of...
Community Engagement Core
SUMMARY COMMUNITY ENGAGEMENT CORE As climate change impacts become increasingly visible in the US Caribbean (Puerto Rico [PR] and US Virgin Islands [USVI]), and adaptation measures...
Strategies to Improve Communication Structure and Quality in Low-resource Childhood Cancer Hospitals
PROJECT SUMMARY/ABSTRACT Children with cancer in low-resource settings face a survival rate of only 20%. Clinical deterioration, defined as the worsening of patient status that req...