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21,042 grants found
Showing 19,221 – 19,240 of 21,042 grants
Proglacial and subglacial aquifers: their evolution under climate change and the potential impacts in terms of resources and natural hazards, through the case of eastern Iceland
The research addressing glacier evolution under climate change is well developed, looking not only at changes in mass balance, but also at the associated effects on basal and downs...
Tumor targeting through a TME-specific regulatory code and programmable CAR T cells
Two major issues hamper successful treatment of solid cancers with CAR T cells. First, immunosuppression imposed by the tumor microenvironment (TME) can compromise CAR T cell funct...
Deciphering the mechanism of the dual functional E3 ligase TRIM28 in cancer cells
TRIM family proteins are RING-type E3 ubiquitin ligases with important roles in immune responses, autophagy and cellular signalling. They are characterised by the presence of an N-...
On-Surface Synthesis, Transfer and Device Fabrication of Novel Carbon-based Nanomaterials
The study of on-surface chemical reactions has attracted recently an enormous interest demonstrating to be a versatile tool for the fabrication of atomically precise covalently bon...
Novel forms of magnetism in 2D transition metal dichalcogenides
The ultimate goal of this project is to demonstrate that the enhanced electronic correlations in transition metal dichalcogenides (TMDs) lead to different expressions of magnetism...
Pietro Bembo's soundscape: a musical tour in the early modern Italian peninsula
The Venetian humanist Pietro Bembo (1470-1547) played a central role in the European Renaissance. His literary works are widely known and his rich epistolary attests both his conta...
Predicting neuropathic pain episodes in spinal cord injury patients through portable EEG and machine learning
Neuropathic pain (NP) is a common symptom arising as a direct consequence of a lesion or disease affecting the somatosensory system. The traditional approach to manage NP patients...
Large scale perturbations of the gene regulatory networks of E. coli
Although genome sequencing is well advanced, our understanding of the genome to phenotype to fitness relationship remains very poor. It is becoming very evident that the informatio...
Surveilling Malaria through machine learning and clustering tools in pregnancy
The vision of the World Health Organisation (WHO) for 2030 is a world free of malaria. For this, agile and robust malaria surveillance systems are required to efficiently guide act...
Hybrid drug-loaded plasmonic photothermal microneedle patch against skin infections
In this proof of concept project, we will assess the technical and commercial feasibility of a hybrid microneedle patch for the treatment of nosocomial skin infections caused by dr...
eXtreme ultraviolet to soft-X-ray Photonic Integrated Circuits
This project aims at the realization of a new technological platform for the development of a EUV - soft X-ray integrated photonics. Integrated photonics is a growing sector of pho...
Artisan pedagogies: investigating craft experts as educators
How do artisans approach their role as educators? As part of long-standing research on world craft practices and their social, cultural, and economic dimensions, anthropologists ha...
Towards EXtreme scale Technologies and Accelerators for euROhpc hw/Sw Supercomputing Applications for exascale
To achieve high performance and high energy efficiency on near-future exascale computing systems, a technology gap needs to be bridged: increase efficiency of computation with extr...
Quantum Thermodynamics in the Solid-state
I propose to realize an electromechanical engine in the solid state, opening a new era of experimental exploration of thermodynamics in open quantum systems. This project leverages...
Hard probes of heavy-ion collisions
Heavy-ion collisions at collider energies are performed in order to produce and study QCD matter at high temperature, the quark-gluon plasma (QGP). Such an extreme state of matter...
Selective Inhibition of NOTCH by novel γ-Secretase Inhibitors in Tumours
Cancer remains one of the deadliest diseases and most deaths are due to treatment failure and metastasis. Tumor resistance and patient outcome are strongly associated with tumor he...
Revolutionizing invasive alien species control using behavioural economics and animal cognition
The aim of COGNITIVE CONTROL is to gain fundamental insights into individual and collective cognition and apply them to the emerging global challenge of invasive animal control. In...
Better safe than sorry? Identifying causes of overprotective parenting in a changing social world
Popular and scientific accounts describe how the phenomenon of overprotective parenting (also labeled helicopter parenting or overparenting) is on the rise. This evolution is highl...
Integrative mechanistic and multi-omics Modelling of Antigen Presentation to predict epitope dynamics
The immune system can patrol cell status by recognising epitopes bound to Human Leukocyte Antigen class I (HLA-I) molecules and triggering cytotoxic T cell (CTL) activation. Epitop...
Elucidating the phenotypic determinants of hybrid vigour
How organismal traits are inherited in offspring is a long-standing, open question. Hybrids between unrelated individuals of plants or animals often show greater vigour, disease re...