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21,042 grants found
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Visualisation of translation initiation reaction on single mRNA molecules in vivo
Translation initiation is a key step in the regulation of protein synthesis and is regulated by at least 12 different initiation factors in eukaryotes (eIFs). However, the underlyi...
Research and innovation for brain health throughout life
The Neuro-Innovation doctoral programme is a new, globally unique effort to train international experts who are wanted in the European job market and future research leaders in bra...
Defining the immunosuppressive milieu of prostate cancer with single cell Omics technologies
The immune contexture of prostate cancer is poorly studied, despite among researchers there is a strong interest in developing immunotherapy approaches to cure the disease. It is k...
Deciphering tumor-promoting mechanisms mediated by neutrophils in vivo
Immunotherapies are revolutionizing cancer care, but are only effective in a minority of patients. Because current treatments typically target T lymphocytes, manipulating other cel...
Automated Model Inference from Neural Dynamics for a Mechanistic Understanding of Cognition
Human cognition depends on complex coordinated dynamics of neural populations, which is shaped by a rich heterogeneity in cellular properties and network connectivity patterns of n...
Bacteriocins and human commensal bacteria as a new strategy to inhibit the opportunistic human pathogen Streptococcus pneumoniae
When the Noble Prize-winning Alexandre Fleming discovered antibiotics, he already noticed that microorganisms developed resistance mechanisms to survive. Therefore, he anticipated...
Targeting dendritic cell plasticity to modulate antigen-specific T cell recall responses in human
The human immune system has the ability to fight various infectious diseases or self-cells turning malignant. Dendritic cells (DCs) are innate immune sensors and professional antig...
Migrating Knowledge: The Global Knowledge Networks of German Medic, Botanist and Migration Commissioner Wilhelm Hillebrand in Hawai‘i (1821-1886)
Taking its lead from my pilot study in the ERC AdG project The Colour of Labour (no. 695573) on the international actors involved in labour migration to 19th-century Hawai‘i, this...
Electrophilic aromatic substitution of azines catalysed by Frustrated Lewis pairs
Azines are nitrogen-containing aromatic rings of utmost synthetic relevance in natural products, pharmaceuticals, agrochemicals and materials science. Although nucleophilic aromat...
DCAF E3 Ligase Exploration To Expand degRadation
PROteolysis TArgeting Chimeras (PROTACs) are molecules with therapeutic potential that induce degradation of target proteins involved in disease. PROTACs are composed of a ligand t...
Parenthood and Parental Desires among LGBTQ People: Generational and Cross-national Perspectives
LGBT rights and non-discrimination policies towards gender and sexual orientation are at the top of the European Union’s priorities. Over the last decades, Western countries greatl...
Career Accelerator for Research Infrastructure Scientists
Scientists engaging in technology development, including method, resource and infrastructure development and respective service provision (both experimentally and computationally),...
CONQUERING SCIENCE ENTHUSIASTS
The ERN event is organised in a physical space - a castle where different areas ensure multiple discovery paths to the visitors. The visitors (grouped in one of four categories: f...
Controlled metal-catalysed polymerisation of SO2-derived sources to high performance and recyclable materials
The burn of sulphur-rich fossil fuels continues to produce sulphur dioxide as a polluting gas, with high risks to humans and the environment. In PolySO2, we aim to uncover new cont...
Opening Up Science
While 2020 can be defined using the word ""Lockdown"", we hope to define 2021 with the words ""Opening Up"". If the world is about to return to normality, the key contributor to th...
GridEye agent-based distributed control for Home Energy Management System
GridEye agent-based distributed control for Home Energy Management System (GEHEMS) explores the theme of energy management for smart homes in the complementary environments of elec...
Encountering Diplomacy in Early Modern Southeast Asia
This research project is a study in global history. It explores how diplomatic practices and foreign relations were shaped in the pluralistic, multi-centric, open geography of mari...
Science in the City, Malta
Science in the City is Malta's national science and arts festival. In 2021 it will be a hybrid event held on the 24th and 25th September. The physical festival will be held in Fort...
Plasmodesmata: gatekeepers for cell-to-cell viral spread in plants
Viruses cause epidemics on all major crops of agronomic importance, representing a serious threat to agriculture and global food security. Among plant viruses, those induced by RNA...
Trajectories of social, emotional and attention problems following very preterm birth: Individual participant data meta-analyses via international data sharing
Each year over two million babies are born very preterm (VP; <32 weeks’ gestational age) and/or with very low birthweight (VLBW; <1500g) worldwide. Despite improved neonatal care,...