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21,042 grants found
Showing 1,761 – 1,780 of 21,042 grants
Overcoming limits for pre-clinical small volume liquid delivery into skin and inflammation quantification
Chronic inflammatory skin diseases have a huge burden on patients, their families, and the economy. New patient-friendly delivery methods are urgently needed targeting immune cells...
Harnessing Specialized Metabolism from Anaerobes
Anaerobic bacteria, a group of microorganisms that thrive in the absence of oxygen, have a significant impact on the quality of life on Earth. They play a crucial role in biotechno...
Massive-binary EvoluTion Across the metallicity Ladder
Do massive stars undergo supernova explosions when collapsing into black holes? What mechanisms drove the Cosmos into an epoch of reionization? How was dust produced in the Early U...
Fluid gap Electro-Active-Polymer machines for a new generation of mechatronic systems
While mechatronic solutions become increasingly pervasive, there are areas, such as the space or the ocean depths, that are still difficult to reach and exploit through conventiona...
Transition from Transport Reindeer Herding to Reindeer Pastoralism: A study of Indigenous Governance during Change
Aboriginal societies around the world have independently transitioned their production mode. In northern Eurasia, the transition manifested itself in a movement away from transport...
Health, Cognition, Family, and Employment among Men
Men are more likely than women to die prematurely, and a great deal of men’s excess mortality is preventable. Improving men’s health and cognition is not only critical for achievin...
Engineering soft microdevices for the mechanical characterization and stimulation of microtissues
As living beings move, touch, or grow, the tissues within them are subject to mechanical stresses that act over minutes, hours, or days. These efforts play a critical role at all s...
(Re-)Writing the Ubiquitin Code – Manipulating Polyubiquitin Chain Linkage to Investigate Ubiquitin Signalling in Genome Maintenance and Beyond
Ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins. The structural diversity of polyubiquitin chains, c...
Tuning Heat Transport in 2D Materials with Defects
The unstoppable race towards miniaturization is pushing the limits of electronics. This has to be conciliated with the inevitable Joule heating that affects all electronic devices,...
Metal-Organic REagents for Light-Enabled Shuttling of protons and electrons
Protons and electrons are the currency of energy conversion and play a key role in some of the most transformative technologies such as the reduction of N2, CO or CO2. Exploiting...
Skills Markets: Marriage and Labor
The distribution of workers across jobs and across different geographic areas has major implications for growth, social welfare and inequality. It is complex but essential to under...
The impact of human aged bone marrow niche on human hematopoietic stem cell function
In humans, aging of the hematopoietic system is associated with anaemia, impaired immune responses and increased frequency of myeloid malignancies. The hematopoietic system is main...
Timing the Economic, Cultural and Environmental patterns of Agropastoralism development in the Indo-Iranian Borderlands
The emergenceThe emergence of an agropastoral way of life in South West Asia from the late 10th millennium BCE revolutionised the social organisation of prehistoric communities. Th...
Critical Geopolitics of Nuclear Fuel Supply in Europe
How do countries build their nuclear fuels supply policies? The ongoing political renaissance of nuclear power through the world raises concerns about European Union states ability...
Harnessing RARA signalling for curative AML therapies
In acute promyelocytic leukaemia (APL), retinoic acid (RA) and arsenic trioxide (ATO) bind the PML/RARA fusion to promote its degradation, derepressing unknown master regulatory ge...
Understanding the molecular basis of protein folding disorders and protein quality control in muscle
Mutations in certain proteins can cause their misfolding and aggregation, posing a potential threat to the health of an organism. Protein aggregation is counteracted by protein qua...
Chiral phononics: Controlling electronic phases with phonon angular momentum
This projects aims to establish a new paradigm in the ultrafast control of solids, by using the angular momentum of chiral lattice vibrations (chiral phonons) to manipulate, induce...
Dissecting the Functional Role of Mucosal IgA Clonal and Glycoprofiles for Effective Humoral Mucosal Protection
Numerous mucosal vaccines and IgA-based monoclonal antibodies aimed at a robust immunity within the respiratory tract are in development to combat viral endemics and pandemics. How...
Mitochondrial Strategies in Ferroptotic Cell Death
Mitochondria serve as the epicenter of cellular metabolism. Their dynamic communication with other compartments within the cell ensures proper cellular function. My recent work rev...
Moving Bodies and Memories of African Slavery in South America
The MOVING project is aimed at developing an ethnographic and multi-disciplinary methodology to study the bodily traces of Africa-originated slavery enduring in post-slavery and di...