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21,042 grants found
Showing 15,681 – 15,700 of 21,042 grants
Towards high-affinity ligands for orphan receptors GPR3, GPR6 & GPR12
The family of G protein-coupled receptors (GPCRs) comprises more than 800 human cell surface receptors that perceive and transmit extracellular stimuli into the cell interior.Due t...
Unravelling the crosstalk between Stellate cells and Kupffer cells and its role in maintaining Stellate cell quiescence
Liver diseases are a global cause of mortality, accounting for two million deaths a year, of which half are attributed to liver fibrosis. Activated stellate cells are the major sou...
Are anthropogenic pollutants in Marine sediments a potential mEthane (CH4) SoURcE (ME4SURE)?
Current climate change and global warming with a continuous increase of methane (CH4) emissions will reshape life on Earth.Oceanic methane emissions are predominantly controlled by...
Characterization of spinal learning in a repetitive yet skilled locomotor task
Animals adjust movement throughout their life to adapt to a changing environment and to learn new motor skills. The underlying mechanisms have been studied for decades, almost excl...
Robust attribution of human-induced thermodynamic and dynamic contributions in historical changes of regional heat and cold waves over Europe
The exceptionally increasing European heat and cold waves in recent decades have been widely attributed to global warming from a thermodynamic perspective.However, contribution of...
Roles of maize PIP2 aquaporins in the structural organization of the cell
Plasma membrane (PM) Intrinsic Proteins (PIPs) are aquaporins that facilitate the diffusion of water through cell membranes. By regulating PIP activity, plant cells adjust water pe...
Healthy Public eNgagemeNt IN Groningen - Chronically Healthy
Healthy Public eNgagemeNt IN Groningen - Chronically Healthy promotes science and scientists on public health in an interactive, accessible and innovative way.Our main goal is to i...
The influence of schools on the off-time transitions to parenthood and partnership
Becoming a parent and moving in to live with a partner are major life events determining individual’s life chances and outcomes.Transitioning to parenthood and partnership at very...
Controlled Synthesis of Panchromatic Electrochromic Polytriarylamines
The goal of COSY-PANTERA is to develop a synthetic route giving access to easy-to-tailor electrochromic panchromatic pi-conjugated polymers that will undergo a clear transparent to...
In vitro reconstitution of the initiation of mitophagosome formation
Mitophagy is a tightly controlled process in which dysfunctional mitochondria are isolated and selectively degraded by autophagy. Many cell types critically rely on this pathway an...
Engineering Phosphorescent and TADF small molecules for white Light-emitting Electrochemical Cells
Light-emitting electrochemical cells (LECs) are getting much attention as single-layered, cost-effective (air-stable electrodes, spray deposition, tolerance to 3D substrates), and...
Beam self-cleaning for spatiotemporal mode-locked fiber lasers
Mode locking (ML) is the most important technique to generate ultrashort laser pulses.Tremendous progress has been made in locking longitudinal modes in lasers with a single transv...
Developing novel inhaled bioengineered Extracellular Vesicle RNA based advanced therapeutics, delivered by tailored aerosol delivery technology for the treatment of lung cancer
Lung cancer (LC) treatments have advanced in recent years with the advent of genetic profiling and immunotherapy. However, LC is a complex heterogeneous disease and survival rates...
Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules
Matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry imaging (MSI) is increasingly used for clinical application.Based on untargeted, spatial chemical information,...
A hybrid atom-photon-phonon quantum processor
Many quantum information processing tasks were first demonstrated with neutral atoms and ions.With improving capabilities of nanofabrication, a growing number of artificial systems...
Wellbeing and Employability for Youths with Psychosocial Disabilities through Digital Technologies
Psychosocial disability (PD) refers to ‘disabilities that arise from barriers to social participation experienced by people who have or who are perceived to have mental conditions...
Experimental investigation of CO2 solubility trapping in heterogeneous 3D porous media
Atmospheric CO2 contributes to 2/3 of the Earth’s global warming by greenhouse effect. Storing CO2 in deep geological formations is the main mitigation measure currently available....
Resilience Estimation to SET management goals in marine ecosystems
In the Anthropocene, global and local cumulative human pressures are heavily impacting ecosystems and threatening societies.Maintaining resilience, i.e. avoiding irrevocable system...
The role of eEF1A in synapse function, maintenance, and synucleinopathy
Synucleinopathies are neurodegenerative conditions characterized by an accumulation of the protein alpha-synuclein, including Parkinson's disease and dementia with Lewy bodies...
Gene Environment interactions in Mental health trajectories of Youth
Youth mental health is heavily burdened, with life-long enduring impact on European citizens and societies.Trajectories of mental health and illness in young people are assumed to...