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21,042 grants found
Showing 15,541 – 15,560 of 21,042 grants
Directed Orchestration of Microfluidic Environments for guided Self-organisation
In Europe, 263 per 10,000 pregnancies are diagnosed with a fetal congenital anomaly.Congenital anomalies, also referred to as birth defects, are defined as structural or functional...
Bioactive Tissue Sealant for Enhanced Wound Repair
Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden.Current tissue sealant formulations that a...
From near extinction to market distinction: Developing a methodology for the sustainable revival of heritage grapevine cultivars
Wine grapes (Vitis vinifera) are among the most sensitive crop to global warming. Elevated temperatures lessen the quality of the grapes and alter their distinctive traits. The thr...
Development of a first-in-class inhibitor of FIH for cancer immunotherapy
We plan to carry out a valorisation project for a series of novel small molecule inhibitors of Factor Inhibiting HIF (FIH) that we have developed for the treatment of lung cancer,...
Coding for DNA Storage
DNA-based storage has attracted significant attention due to recent demonstrations of the viability of storing information in macromolecules.Unlike classical optical and magnetic s...
Early-Stage Organocatalysis
Organocatalysis has drastically advanced stereoselective chemical synthesis. From an underdeveloped niche area, it has become the most frequently applied approach to asymmetric syn...
Direct detection of coherent signals using Fano devices
This ERC PoC project aims to explore the commercial potential of a new and promising approach for realizing cheap integrated detectors with low energy consumption for use in high-s...
EXamining how Past demography affects genetic LOad using Ancient DNA
DNA can survive millennia post-mortem, spanning ecological and evolutionary transitions and providing a unique window into the processes underlying biodiversity.As such sequencing...
Training Alone to Play Together App
Making music together requires not only individual skills and musical expertise, but the ability to coordinate one's actions with others. Typically, musicians try to improve t...
Scanning probe microscopy in high vectorial magnetic fields: New device for imaging quantum materials
The invention of the scanning tunneling microscope (STM) and of other similar devices was a revolution for research at atomic scale.Many companies offer microscopes which can be us...
Lectibodies to Eliminate Tumours
Antibody-mediated delivery of therapeutic compounds to tumor cells for the treatment of cancer is a rapidly growing multibillion-euro market.One class of tumor markers, the glycosp...
Single molecule reconstruction for high-throughput, short-read sequencing technologies
Current advanced short-read sequencing technologies and third generation long-read sequencing technologies are still not capable of full molecule reconstruction in a high throughpu...
Cell Rejuvenation Therapy for Age-related Macular Degeneration
Age-related macular degeneration (AMD) is a leading cause for blindness, resulting in loss of vision at the center of the visual field - the macula, due to damage to the retina.The...
Mechanisms at the interface of DNA damage repair and transcription
Bulky DNA lesions are a major obstacle during gene transcription by RNA polymerase II enzymes (RNAPII). The stalling of RNAPII at DNA lesions triggers a genome-wide transcriptional...
Photoelectrosynthetic processes in continuous-flow under concentrated sunlight: combining efficiency with selectivity
To be the first CO2-neutral continent by 2050, Europe needs to develop and implement disruptive new technologies, based on scientific breakthroughs.In this regard, utilization of C...
Skin micro-injector
Needle-based injections are very common in modern medicine, notably in ongoing vaccination efforts worldwide.However, needle phobia and infection risks affect patient compliance wi...
Targetting neutrophil-mediated neurotoxicity for the treatment of Alzheimer's Disease
With the NeutrAD ERC PoC project, we present the first disease-modifying Alzheimers Disease (AD) drugs that abrogate leukocyte-mediated neurotoxicity and represent a novel class of...
Methyltransferase inhibitors for treatment of COVID19
Our IP secured drug DZNep is effective in treating SARS-CoV-2 infections in preclinical disease models and uniquely suppresses virus growth, triggers the innate immunity and facili...
Phase Contrast STEM for Cryo-EM
Cryo-electron microscopy has revolutionized the field of structural biology, primarily for macromolecular structure but also for cells and tissue sections—achieving resolutions at...
Niche geometry as the regulator of communal metabolism and cell fate
Tissue renewal by adult stem cells is regulated by a multitude of cell intrinsic and extrinsic mechanism, which jointly guide decisions between stem cell self-renewal and different...