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21,042 grants found
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Unravelling the mechanism of eukaryotic helicase activation
The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome duplication only once per cell cycle.Duri...
Face Off. Understanding Ancient Masks
“Face Off” is designed as an interdisciplinary project, whose main goal is the first comprehensive investigation and comparison of masking phenomena in the Iron Age Mediterranean (...
Climate ReOrganizations at Synoptic Scale as Recorded in the Offshore Archives of the Dead Sea
Water availability in the Mediterranean basin is projected to decrease in the future in the 6th IPCC report.It is largely influenced by wintertime synoptic atmospheric circulations...
Time and quantification in cognition, communication and cultural practice
This project investigates the relationship between time and number in human cognition, focusing on how this relationship is culturally and linguistically configured. This area rema...
Enabling institutional change for innovation in European peripheries: from policy to implementation
PeripheRIS undertakes research to enable institutional support for innovation policy in European peripheries, with a focus on policy implementation.For more than a decade since the...
Origin of genomic instability: Understanding the biological influence of inflammation in the initiation of pancreatic tumorigenesis
Inflammation is suspected to be the first step leading to cancer due to alcohol consumption or tobacco smoking between others. Little is known of how inflammation triggers genetic...
Foundation of Nonrelativistic String Theory and Its Applications to Holography
One of the most profound problems in modern theoretical physics concerns the formulation of quantum gravity. A predominating paradigm for addressing questions in quantum gravity is...
Modelling sister chromatids cohesion
The proposed project aims at modeling the structure and mechanisms of sister chromatids cohesion, and how it coordinates with intra-chromatid organization to shape replicated human...
Genetic regulation and functional relevance of maize starchy endosperm programmed cell death
Around 60% of our daily diet is directly derived from cereal grains. In the grain, most nutrients are stored in a highly specialized reserve tissue called the starchy endosperm (SE...
Plastic litter in macrophyte system: environmental fate and ecological implications
Plastic is an emerging environmental contaminant that attracts social, political, and scientific attention.However, the effect mechanisms and ecological conditions that promote the...
Women Translators in Italian Publishing
The project re-evaluates womens participation in 1930s-1980s Italian intellectual discourse, through a special focus on the intersection of translation and publishing.More specific...
Deciphering the dialogue between intestinal macrophages and their tissular niches
Besides their role as immune sentinels, macrophages fulfil specific functions that are strictly related to their tissue of residence.As an example, the loss of gut macrophages is c...
In vitro brain microvascular model to tackle fever in cerebral malaria
Malaria still claims more than 400,000 deaths every year, above all in children under 5.All symptoms are caused by the blood stage of the deadliest parasite species Plasmodium falc...
PIK3CA-Related Overgrowth Spectrum: molecular mechanisms and preclinical modelling of PIK3CA VARIANTs
PIK3CA-related overgrowth spectrum (PROS) is a group of rare congenital disorders that manifest as complex syndromes with overgrowth of several tissues (vasculature, adipose and mu...
Early Modern State Development in Yemen
How do early modern states organize effective rule in difficult conditions?EMStaD YEMEN focuses on a country that due to its geographical, religious and social complexities is now...
The fate of TERRestriAl forest CARBon from photosynthesis to structural biomass under climate change
Forests play a major role in the global carbon cycle.They uptake carbon through photosynthesis, return much of it through respiration, and accumulate some fraction as structural bi...
Artificial Intelligence meets Material Genome: intelligent design of new MOFs for xylene separation challenge.
Chemical separation technologies consume 15% of the global energy.Separation of xylene, a common chemical produced on an enormous scale, is one of the most difficult cases, due to...
Curve Counting and Log Geometry
The Gromov--Witten invariants of a space X record the number of curves in X of a given genus and degree which meet a given collection of cycles in X.Gromov--Witten theory is an ext...
Magnetism for the Functionalization of Metallic Materials Surfaces and its effect on Corrosion Phenomena
The proposed research program will focus on characterisation of electrochemical behaviour of structural materials with emphasis on phenomena of aqueous corrosion in the presence of...
Unlocking the potential of laser 3D printing with ultrasound
If successful, this project will be a milestone in the development of 3D printing of metals by laser-directed energy deposition.The purpose of this project is to establish a scient...