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21,042 grants found
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The Ethics of Loneliness and Sociability
Loneliness, which can be defined as the negative mental states (e.g. sadness, despair) that people experience when they feel that they do not have enough relationships, or not the...
Understanding motivations to seek and carry out female genital plastic surgeries to contribute to better informed decision-making of girls/women and to support medics in developing ethical practices
This project investigates why girls and women in Belgium and the Netherlands (increasingly) seek female genital plastic surgeries (FGPS) and how healthcare practitioners handle req...
Engineering CAR-T cells to overcome glycosylation-driven tumour resistance
T cells engineered to express tumour-specific chimeric antigen receptors (CAR) proved effective against B-cell tumours. However, as the technology moves to solid cancers, clinical...
e-Intervention Enhancing Mental Health in Adolescents
The e-Intervention Enhancing Mental Health in Adolescents project, IMPROVA, will co-design, pilot, evaluate, and facilitate the upscaling of a modular eHealth intervention platform...
Philosophy of COSMOlogy: Matter And SpaceTime ERadicated
Our most basic, fundamental assumptions are often the ones that get scrutinised the least.This very much holds true for the primary ontological and conceptual distinction that unde...
Breaching the protective cancer stroma with radiotherapy-responsive liposomes
Liposomes have been the most successful type of nanomedicine for cancer patients, playing a leading role in improving the tolerability of chemotherapeutics.However, to advance the...
Pathways of resilience and evasion of tipping in ecosystems
There is an urgent need to understand the catastrophic effects that global environmental and climate change can have on the Earth, its system components and ecosystems. One area of...
A revolutionary cell programming platform based on the targeted nano-delivery of a transposon gene editing system
Aim: The NANO-ENGINE project aims to develop a first-in-class, DNA-based, non-viral, targeted in vivo cell programming technology that can be utilized for treating a broad range of...
Improving the living and labour conditions of irregularised migrant households in Europe
The project investigates the living and working conditions of irregularised migrant households in Europe from an intersectional perspective.It aims to reveal the spectrum of irregu...
From one closed door to another: Cumulative discrimination and prejudice against marginalised groups in Europe
The main contribution of EqualStrength is to investigate cumulative and structural forms of discrimination, outgroup prejudice and hate crimes against ethnic, racial and religious...
Illuminating the enteroviral life cycle
Enteroviruses are highly prevalent pathogens that have enormous clinical and socio-economic impact. Well-known examples are poliovirus, coxsackievirus, enterovirus-A71, enterovirus...
Tracing Indigenous American genomic history, subsistence strategies, health and their interplay through time using DNA from ancient masticated plant fibres
Palaeogenomics has revolutionised our understanding of human population history at the biological and sociocultural level by analysing thousands of ancient human genomes sequenced...
HydrOdynamics & biomechanics of canceR cell mIgration in heterOgeNeous media
So far medicine has not solved the workings of a formidable and scientifically challenging aspect of cancer: metastasis, the migration of circulating tumor cells (CTC) through the...
Paracrine signalling in alpha cells and the integration of mechanisms that control glucagon secretion
Diabetes is a common disease affecting millions of patients world-vide. The disease is characterised by hyperglycaemia, caused by reduced insulin signalling and release. Recent fin...
Unveiling Gravitational Waves from Galactic Nuclei
To date, the mechanisms that trigger the formation and gravitational wave (GW) coalescence of compact-object (CO, black holes, neutron stars, white dwarfs) binaries are still unkno...
Hyper-targeting CAR NK cells from induced pluripotent stem cells for novel off-the-shelf anti-tumor therapies
The HyperTargIPS-NK project aims to combine novel technologies from three research laboratories and a stem cell company to develop a revolutionary therapeutic modality for patients...
Wild grapevines endophytic microbiome: ecology, epigenetics and application in the biological control of wood pathogens, a synthetic microbiome approach.
In recent years, a general decline has been documented in several agriculturally relevant woody plants, and numerousreports point towards a possible role of the plant-associated mi...
Conformations of High Topological Genus Membranes
Biomembranes are fundamental to our understanding of the cell, the basic building block of all life. An intriguing aspect of membranes is their ability to assume a variety of shape...
Novel Approaches to Error Detection and Protection with Superconducting Qubits
Superconducting qubits have emerged as a leading platform for realizing intermediate- and large-scale quantum computing and quantum simulation.This success has been due to the exce...
Nerve Growth Factor Delivery into the Brain – focus on therapeutic potential in Alzheimer’s disease and In Vivo Evaluation via PET
Alzheimer’s disease (AD) is a neurodegenerative disease affecting the aged population and is projected to increase 3-fold in the next 30-years.Treatment options in AD are limited d...