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21,042 grants found
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Identifying principles and mechanisms of cell cycle control in Bacteroides species.
The gut hosts a complex community of bacteria, archaea, and viruses, which together play a key role in shaping human health. The microbiome has featured in extensive metagenomic st...
Enhancing immunotherapies against solid tumors with TLR-switch receptor-armored T cells (TLR-T cells)
Immunotherapy, particularly adoptive T cell therapies (ACT), has revolutionized cancer treatment, providing significant benefits to patients with haematological malignancies. Despi...
SUPRAmolecular Hydrogel Driven Assembly of Designer Heart Tissues
The SUPRAHEART proof-of-concept project aims to use our squaramide-based (SQ) filamentous double network hydrogels for assembly of engineered heart tissues (EHTs). As the current d...
The Constitutional Road to Dictatorship: States of Exception and Authoritarianism in Europe, 1900-39
STEXEU investigates the impact of states of exception on democracy in early-twentieth century Europe. In the interwar years, and sometimes before, democratic rule came under strain...
Untapping multiparametric 2D luminescence sensing through MACHine LEarning and Spectral Sorting
Cellular organisms are complex machines whose health and functioning are dictated by parameters including temperature, oxygen concentration, and pH. Luminescence nanosensing is a t...
Accurate simulations of photochemical and photophysical processes at materials interfaces
The PhotoMat project will develop highly accurate methods for the prediction of excited-state properties and dynamics of materials interfaces based on ab initio Green's function th...
Exploring natural selection due to the Black Death and continuous human population genetic structure
The study of ancient human DNA has been revolutionary in identifying large-scale admixtures and genetic variants subject to natural selection. Yet, key knowledge gaps persist. Firs...
Bispecific bi-paratopic antibodies for the treatment of cancer
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the majority of patients do not respond to current treatments, such as PD-1/PD-L1blockade. In non-small cell lu...
Participatory Algorithmic Justice: A multi-sited ethnography to advance algorithmic justice through participatory design
AI comes with great promises, but more critically, it comes with demonstrated harms, from racial and gender bias, to discrimination, wrongful arrests, defamation, surveillance, or...
Actuation spectroscopy as a new label-free tool to study protein properties in real time
Proteins carry out all functions in living cells, from division, metabolism and transport to programmed cell death. Understanding how protein structure and movements relate to thei...
Light Emitting Silicon Germanium
Our vision is to revolutionize information and quantum technologies by blending photonic and electronic functionality onto a single chip. This long-standing challenge has remained...
Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes mellitus (T2DM). However, a subset of patients does not respond to these a...
Bis(carbene) Analogues of Aluminium and Gallium as Building Blocks for Highly Selective Reagents and Next Generation Catalysts
Molecular chemistry impacts on a wide range of transformational activities that the society relies on and thus plays a key role in addressing the societal challenges facing the Eur...
Broad-spectrum Antiviral siRNAs: Influenza Strains Targeted by Anticipation
Fighting emerging viruses has been a major challenge in the development of novel therapeutics. With the current global changes and massive modification of the biosphere, the issue...
Artificial molecular machines in membranes: transmembrane relays for ion transport, catalysis and cargo pumping
This program will develop artificial molecular machines confined within lipid bilayer membranes, to control transmembrane transport and catalysis in cellular systems. Molecular mac...
Understanding the Role of Economic Imagination for Advancing Decarbonization in Europe
How do we imagine the decarbonized economy of the future? While research suggests that opposition to climate mitigation is often driven by economic concerns, we have little systema...
Meteotsunami detection and tracking: Developing a solution based on assessment of real-time measurements
Meteorological tsunamis (meteotsunamis) are long ocean waves (periods of: 1 < T < ~120 min) that have the same periods, wavelengths and amplitudes as seismic tsunamis, but are gene...
Promiscuous Print: Legal Deposit Libraries, Rejected Texts, and New Methods for Negative Bibliography
PROMPRINT will uncover and analyze the rejects of legal deposit: the printed texts excluded from the ostensibly universal archive promised by copyright libraries. Legal deposit wor...
Dynamic Megabar Chemistry
Pressures above 1 Mbar, equivalent to energy densities stored in chemical bonds, are predicted to severely reshape the periodic table of the elements as we know it. Such extreme co...
Ring laser gyroscopes for ground motion sensing
Sensors for rotation are ubiquitous in our daily life, ranging from consumer electronics to navigation systems. Applications that require highest sensitivity for very small rotatio...