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21,042 grants found
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Air shower interferometry to advance astroparticle physics
The universe hosts a population of subatomic particles with astonishingly high kinetic energies, so-called cosmic rays. Where and how they obtain this energy is unknown. These part...
Genomic Signatures of Selection In Structured Populations: Detecting Temporal Shifts and Local Adaptation
Demographic and selective processes jointly influence the distribution of species in space and time. However, their interaction remains poorly studied despite its potential to form...
PRESERT: linking prefrontal cortex, serotonin transporter and social cognition.
Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1 billion people worldwide. Common alterations are in the cognitive a...
Deep representational learning of the evolutionary DNA code in the vertebrate pallium
Vertebrate genomes consist of tens of thousands of genes and yet they produce only a limited number of stable cell types. Our understanding of how cell types are encoded in the gen...
Cryo-ET of Alphavirus Replication Complex (CryoARC)
Positive-sense single-stranded RNA (+ssRNA) viruses replicate their genomes in membrane-bound, virus-induced replication complexes (RCs). A major genus of +ssRNA viruses are the Al...
Deciphering the newly discovered branchial cavity immune surveillance system to protect fish against infectious diseases in aquaculture.
The sustainability of aquaculture, an important food source for human, is severely challenged by infectious diseases. Unfortunately, the development of new therapies and vaccines i...
Expanding the genome editing toolbox by rational reprogramming of tyrosine recombinase DNA specificities
Gene therapies aim to cure genetic diseases by modifying the DNA blueprint. An ideal gene therapy should be durable, safe, and efficient, which often requires integration of large...
Data-driven market power in the production of addiction
The DATA-ADDICT project studies data-driven market power in the production of addiction. It focuses on online gambling as a key empirical example of a highly addictive, digital, an...
Developing Correct Concurrent Software Using Types
Modern society runs on concurrent software: different processes (threads) jointly process massive data sets and serve many clients and users simultaneously. Good methods to ensure...
PrEdicting Nucleation to support next-generation microtechnology: Diffuse Interface, fluctuating hydrodynamics and rare events.
There is a noticeable trend in simulations of fluid processes to try to be as much as possible multiscale, i.e. to carry out simulations from molecular scale to hydrodynamics. This...
Theranostic Peptide Tracers for Breast Cancer
Breast cancer impacts one in eight women globally, resulting in over half a million deaths each year. Current diagnostic methods fall short, with ~40% of breast cancers having alre...
Multi-kingdom biodiversity in residential environments and immune-mediated diseases in children
All organisms constantly shed traces of their DNA in the environment. Scientists can collect this DNA and explore who is or was there, across kingdoms of life. Our immune system is...
Mechanism of facilitated homology search and the logic of its meiotic regulations
DNA double-strand breaks (DSB) repair by homologous recombination (HR) entails identification of an intact homologous template DNA molecule in the genome. Homology search is guided...
Reconfiguring Moiré Quantum Materials on Demand through Strain Engineering
The rise of moiré materials based on twisted layers of two-dimensional (2D) crystals constitutes arguably one of the most exciting opportunities in the manipulation of synthetic qu...
Changing Childhoods in the Early Era of the WWW
Online connectivity permeates the lives of contemporary children. Nonetheless, the history of childhood and the World Wide Web (the Web) has not been studieda lacuna which mirrors...
Addressing the role of self-organization in tumor heterogeneity and plasticity
Colorectal cancer (CRC) remains a major health challenge, with a survival rate of 15% in stage IV cases due to therapy resistance and tumor relapse. A key barrier to effective trea...
Preclinical in vitro Models for the Replacement, Reduction and Refinement of Mouse Models in Preclinical Studies (PRIM-TECH3R)
The use of mouse models in biomedical research has been pivotal in understanding human diseases due to their genetic and physiological similarities to humans. However, concerns on...
Development of a novel hiPSCs-derived Vascularized-Epicardial-Adipose-Tissue-on-Chip model to investigate cellular crosstalk in healthy and stressed states
Obesity-associated metabolic and cardiovascular diseases (CVDs) are serious public health concerns. A fat depot surrounding the heart, known as epicardial adipose tissue (EAT), is...
Quantum Synthesis
Quantum circuits form the basic building blocks of quantum computers and algorithms.Current quantum algorithms are created and analysed manually and in an ad-hoc manner. We want to...
Solar Cells-Inspired Inorganic Semiconductor Synaptic Systems for Low Energy Edge Computing and Visual Learning
The rapidly expanding field of artificial intelligence (AI) and machine learning exposes the limitations of conventional Von Neumann architecture. Neuromorphic computing, inspired...