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21,042 grants found
Showing 6,761 – 6,780 of 21,042 grants
Building models of, with and for sustainability transformations
While the need for sustainability transformations is ubiquitous, understanding why and how they succeed or fail is limited. Explanations often focus on either agency-related or sys...
Hyperfine coupled spins with time evolution readout
Quantum simulation is a promising strategy for understanding the behaviour of quantum systems that are too complex to be calculated directly.HYPSTER will make crucial steps towards...
Hierarchical gradient metals by additive manufacturing
Over the last decade, the steadily increasing research on gradient-structured metals and alloys has demonstrated great successes of this biological and nature-inspired concept to e...
Revealing Elusive LIght particles with Cosmic microwave background surveys across cosmological Scales
Neutrinos and other well-motivated particles from the Big Bang are gateways to much awaited new physics that will sharpen our understanding of Nature.Cosmology offers a unique aren...
Dissecting the biophysical mechanisms of deep brain stimulation using voltage fluorescence microscopy
Deep brain stimulation (DBS) is a promising neuromodulation technique for the treatment of neurological and psychiatric diseases. DBS electrically stimulates brain tissue via impla...
Learning the interaction rules of antibody-antigen binding
Antibody-antigen binding is the basis of two fundamental biotherapeutic pillars: monoclonal antibodies (1) and vaccines (2). To accelerate therapeutics discovery, we need to perfor...
Theory and principles of luminescent organic radical materials for OLED and sensor applications
Organic luminescent radicals (OLRs) are quite rare emitters demonstrating doublet-doublet fluorescence and having a number of advantages towards practical applications in organic l...
Subcutaneous delivery of theranostic cell-based therapies
This PoC project seeks to develop a simple-to-implement self-assembled and injectable hydrogel material for the controlled co-delivery of our simili-CAR NK cells and stimulatory cy...
Linker molecules convert commercial fluorophores into tailored functional probes during biolabeling
Fluorescence techniques are indispensable tools at the heart of basic research, medical diagnostics, cancer research, personalized medicine and drug screening.Their merits are not...
Destabilizing vascular colonization to stop meningitis
Before the antibiotic era chances of survival to bacterial meningitis were minimal.Nevertheless, nearly 100-years later, surprisingly little progress has been made and mortality ra...
Opposites attract: Crosstalk between vimentin and microtubules - mechanical stability vs. dynamic adaptability
The cytoskeleton is mainly composed of actin, microtubules, and intermediate filaments.It is fundamentally important for many cellular processes, which is reflected in its morpholo...
A Gamma-ray Infrastructure to Advance Gravitational Wave Astrophysics
When galaxies merge, do their central supermassive black holes also merge? How does the merger affect star formation and the evolution of galaxies? How does physics beyond the Stan...
Visualizing microbial societies: exposing the principles of single-cell phenotypic heterogeneity via massively multiplexed imaging
Bacteria are social organisms that interact and coordinate their behaviors to shape our world. Whereas their clonal populations are genetically identical, they contain phenotypical...
Melanosomes as cancer immune modulators: a novel paradigm in melanoma immunity
Despite remarkable progress in treating melanoma, the most lethal of human skin cancers, 50% of patients are treatment-resistant, with most experiencing disease recurrence.Our rece...
A 3D-printable biomimetic bone regeneration material
Critical-size bone defects do not heal spontaneously over the patient’s lifetime and cause substantial individual, societal and economic burden.Current treatment options are hamper...
CHARTING THE TOKEN OF TIME: YAP/TAZ TRANSCRIPTIONAL REGULATORS AT THE ROOTS OF AGING
A major challenge in aging research is to distinguish which age-related alterations play a driving role and their interconnections.Aging ultimately implies dysregulated transcripti...
POLarization Orientation CALibrator for Cosmology
I will enable groundbreaking results for cosmology and fundamental physics, thanks to a novel method for measuring the angle of the polarization plane of the Cosmic Microwave Backg...
Rewire the lymph node niche to instruct T cell immunity
Lymph nodes (LN) are communication centers within the lymphatic network that instruct T cell priming and differentiation in homeostasis and disease. Multiple layers of control are...
Social Inequalities in the Risk and Aftermath of Miscarriage
One in four women experience a miscarriage. Loss of pregnancy may affect fertility intentions and lead to adverse mental and physical health.Yet, we know little about how social in...
Federated foundational models for embodied perception
Computer vision is beginning to see a paradigm shift with large-scale foundational models that demonstrate impressive results on a wide range of recognition tasks.While achieving i...