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21,042 grants found
Showing 6,681 – 6,700 of 21,042 grants
Tracking Long-Term Resilience in Arctic Sociocultural-Ecological Systems
Like many Indigenous peoples around the world, Inuit of Foxe Basin, central Arctic Canada, view hunting and the food security it provides to be a collective cornerstone of their cu...
Unmasking the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution
Although oncogenic driver mutations are found in healthy tissues sometimes at a prenatal stage, they do not often result in overt cancer.This genotype – phenotype discrepancy warre...
New directions for deep learning in cancer research through concept explainability and virtual experimentation.
Deep learning (DL) is rapidly transforming cancer research and oncology. DL can extract subtle visual features from preclinical and clinical image data.In my junior research group,...
Targeting the Polycomb Machinery in BAP1-related Pathologies
BAP1-related mutations are common genetic lesions of several cancers and neurodevelopmental disorders (NDDs).BAP1 is a deubiquitinase that removes the repressive mono-ubiquitinatio...
Tracing single-cell scale chemical signaling between interacting soil fungi
Multiple species of fungi co-exist in soils and play an important role in biogeochemical cycles.To survive in a resource limited environment, they have developed the means for inte...
PROstate Focal THerapy
The PROFTH project aims at developing the robotics and AI technologies to enable focal therapies for prostate cancer (PCa) using the robotic positioned developed during the ERC-PoC...
Literary Games, Poetics and the Early-Modern Novel
Literary games were a wide-spread practice in seventeenth-century France, and prominent novelists wrote fictions about a salon company playing the “game of the novel” (jeu du roman...
Sleeping While Awake: Sleep intrusions during wakefulness and their cognitive consequences
What happens in our brains when we get tired?Mental fatigue can occur for diverse reasons, through extended periods of wakefulness or following intense cognitive efforts. In other...
Conjugation of NAD-capped RNAs to proteins by ADP-ribosyltransferases to generate RNA therapeutics
Background: We discovered that NAD-capped RNAs can be covalently attached to specific target proteins by the phage T4 ADP-ribosyltransferase (ART) ModB, which we term RNAylation.Sc...
TACKLING FUNCTIONAL MATURATION FOR TRANSPLANTABLE HEMATOPOIETIC STEM CELL GENERATION
Hematopoietic stem cells (HSC) provide a lifelong supply of blood and immune cells.They are a life-saving therapy for leukemia and have recently found broadened applications to gen...
Propagation of cellular memory through dormancy
Decades of work established the importance of dormant cells in reproduction and regeneration, however, a central unsolved question is how the cell propagates transcriptional memory...
Developing Experience-Centric Accessible Immersive Virtual Reality Technology
AccessVR will fill the gap in the scientific knowledge on how people with physical disability – particularly people with limited upper- and lower body mobility – access and experie...
Agile Ultra-Scale Communications Using Optical Arbitrary Waveform Generation and Measurement
TeraGEAR aims at exploring and verifying the innovation potential of a novel class of optical signal-processing systems that might be of transformative impact to optical communicat...
Automated, miniaturized and accelerated drug discovery: AMADEUS
The mantra ‘Automation + Miniaturization = Acceleration’ is successfully applied in many research areas and technologies, but not in synthetic chemistry, which is largely believed...
Sustainable Plasmonic Membranes for Water Remediation
Plasmon chemistry is an emerging field in which light energy is converted into chemical energy or heat in metal nanoparticles (NPs).Previously, we have investigated the degradation...
Distributed wireless EEG sensor patches for auditory attention decoding in hearing technology
Over 400 million people worldwide suffer from disabling hearing loss.While the majority can be helped with a hearing aid, users still experience major difficulties in situations wh...
Temporal processing in Drosophila melanogaster
All information processing in nervous systems relies on spatial and temporal patterns of neural activity.While spatial patterns are dictated by neuroanatomy, the mechanisms that gi...
Guard-driven immunity against pathogens
Successful pathogens use virulence factors to inhibit immune defenses.To counteract this, host guard proteins monitor the integrity of pathways (guardees) that are attacked by viru...
The active travel backlash paradox: opposition and acceptability determinants of built environment-based sustainable travel interventions
Transport policy is a contentious issue.In recent years, ambitious proposals aiming at reducing car use and creating a more sustainable, equitable, and healthy transportation syste...
TREASURES: Digging into dwarf galaxies
The Milky Way is an environment rich with satellite galaxies, stellar streams and accreted systems. Encoded in these structures is the formation and evolution of the Galaxy through...