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21,042 grants found
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Powder Metallurgy Combined with Cryogenic Laser Shock Peening: a Novel Surface Plastic Deformation Process to Achieve Advanced Nanotwinned Aluminum/graphene-CNT Composites
The trade-off between stacking fault energy and capability of twining has been a roadblock in aluminum (Al) composites, due to low dislocation storage and weak strain hardening abi...
The dynamic structure of protein domains within the cytoplasmic membrane of Escherichia coli
Membrane proteins govern how bacteria inside the human body, animals, plants, water sources or soil interact with their environment.Membrane proteins show intricate spatial organiz...
Deciphering METAstasis of lung cancer to BRAIN and developing new therapeutic approaches via a human metastatic cascade platform
Brain metastases have a poor prognosis and are associated with a high morbidity and mortality rate in cancer patients. The metastatic pathways and the role of the blood-brain barri...
Mechanisms of Camouflage in Cuttlefish
Cephalopod camouflage (or crypsis) is one of the most fascinating behaviors in the animal kingdom. It is also very relevant for neuroscience, for many reasons.First, the ability of...
Curing ovarian cancer through autoantibody-based therapy
Ovarian cancer (OC) is a malignant tumor with poor prognosis and limited treatment options, responsible for 4.4% of cancer-related mortality in women. There is an urgent need for i...
Engineering Eco-Friendly and Sustainable Reflecting Crystals in Yeast to Replace Hazardous TiO2 Based Pigments
The superior optical properties and stability of Titanium dioxide (TiO2) has made the material attractive to many industries, for use in food, cosmetics, and pharmaceuticals.Despit...
Greenhouses as Vital Landscapes: Sustainability, Relationality, and the Future of Food
Greenhouses play a crucial role in Europe, ensuring the production of affordable vegetables, but they are under great pressure to change.The EU is encouraging consumers to move tow...
Understanding Lightning from the Lab: Initiation, Propagation, and X-ray Emissions
Despite the huge impact of lightning, its fundamental properties are still very poorly understood.With this project I want to build an infrastructure of carefully designed laborato...
Narrative Archetypes for Artificial Intelligence
AI STORIES is premised on the hypothesis that narrative archetypes fundamentally structure the output of contemporary artificial intelligence (AI).Large language models (LLMs) like...
Revealing the structure and mechanism of mitotic chromosome folding inside the cell
Mitosis is a fundamental biological process every cell undergoes at least once.It requires a dynamic and dramatic restructuring of the genome from extended interphase chromatin to...
Language geography and the dynamics of linguistic and population prehistory
The LANGUGE REDUX project addresses the continuing challenge of understanding the processes that have shaped linguistic diversity.Aiming to push deeper into linguistic prehistory,...
Computational design of synthetic antibody repertoires for accelerated therapeutic discovery
Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solub...
Photocatalytic Methylations via Direct Methane Functionalization
Methane is one of the most abundant, underutilized carbon-based chemical feedstocks on the planet.Moreover, the simplest alkane is one of the most potent greenhouse gases in the at...
Ultra-sensitive Field-resolved Infrared Spectroscopy for Early Disease Detection
Early detection is one of the most effective ways to improve the survival rate for diseases like cancer.However, current diagnoses often rely on invasive procedures and specialized...
Do AI generated outputs have contents?
This project asks: do the outputs of machine learning neural net AI systems (henceforth, ‘AI systems’) have contents i.e., do they have meanings, express propositions, or represent...
Developing a human-based stem cell model for reproductive toxicity
Environmental factors and chemicals are thought to be one cause of declining male fertility. Reproductive toxicity is becoming a major public health problem.Currently, new pharmaco...
Confronting Thompson’s Conjecture: A Hypercontractive Approach
This proposal concerns enhancing our understanding of linear algebraic group via methods from Boolean function analysis.In particular, it is focused on addressing Thompson's c...
Analytic Number Theory and Arithmetic Statistics over Function Fields
An archetypal problem in multiplicative number theory is to determine the factorization statistics in a given set, such as the set of values of an integral polynomial, or of the fu...
Deciphering Antigen-Specific Circuits Orchestrating Tolerance.
Peripheral regulatory T cell (pTreg) responses are critical in inhibiting inflammation to external harmless antigens.Studying their regulation and function is crucial for developin...
Not Knowing in Deep Representation Learning
Machine learning and artificial intelligence techniques are progressing at a tremendous pace and impressive results appear across scientific fields.However, as machine learning mod...