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21,042 grants found
Showing 2,201 – 2,220 of 21,042 grants
Sifting through the 3D Genome: Computational Models of Homology Search in DNA Repair
Homology-directed repair is an essential, evolutionary conserved DNA repair pathway that accurately restores genetic information lost due to double-stranded breaks. Its key step is...
OPTimising IndiGOidine production heterogeneity for sustainable microbial blue pigment biosynthesis
The textile industry is a major global contributor to environmental pollution, primarily due to the harsh conditions and hazardous chemicals used in fabric pre-treatment, dyeing, a...
Optoelectronic and all-optical hyperspin machines for large-scale computing
Efficient hardware for combinatorial optimization and machine learning impacts science, engineering, and society. With new computational models, photonics tackle problems intractab...
Ant navigation: understanding the resilience and self-developing nature of mini-brains in interaction with their environment.
Organisms differ from machines in their resilience: their capacity to spontaneously recover from defects. This is because organisms, contrary to machines, are self-developing syste...
Revival of the Powerhouse: How mitochondrial remodelling controls the energy metabolism of the malaria parasite to enable survival in different hosts
The mitochondrion of the malaria agent Plasmodium falciparum is critical for parasite survival and a confirmed drug target. The dynamic organelle undergoes a Plasmodium-specific me...
Brainstem circuits supporting adaptive instinctive behaviours
Instinctive behaviours that achieve defence, feeding, aggression and parental care have evolved across animal phyla to ensure survival without the need for learning. Contrary to co...
Shaping the bacterial envelope: Interplay between the components and impact on antibiotic resistance
Gram-negative bacteria are notoriously resilient, dominating the list of pathogens requiring urgent medical attention. Fundamental to their remarkable antibiotic resistance is a tr...
The Everyday Politics of Famine
Famines are becoming more frequent and deadly, with 250,000 people experiencing famine in 2022 and 35 million people being on the edge of famine. For decades there has been a scho...
Buddhism’s Early Spread to Tibet: Dunhuang and the Influence of Sinitic Scriptures
Modern scholarship follows emic accounts in situating the origins of Tibetan Buddhism squarely in India, tacitly accepting Tibet’s claim to be heir to the orthodox tradi-tion. This...
Microfoundations of Collective Defence
Does the success of military alliances ultimately hang on the whims of public opinion? The historical record shows that allied states often do not honour their collective defence c...
IDENTITY COMPRESSION: a fundamental breakthrough in social identity, social information, and social polarization
The breakthrough to be pursued in ID-COMPRESSION is that social polarization is information compressibility, where attitudes provide redundant information about group membership. I...
Ethics and Moral Life in the 18th Century: A New Take on Early Modern Ethics
Early modern ethics has so far been investigated with regard to the debates on the foundations of morality, moral knowledge and the status of moral principles. Despite their achiev...
Cellular Strategies of Protein Quality Control-Degradation
Maintaining the quality of all proteins in an organism is fundamental to life since it ensures tissue function, organismal health, and longevity. Protein quality control (PQC) is a...
Implantable microroBOT
Small-scale medical robotics was born from a science fiction vision: shrinking down a group of surgeons and letting them swim to the brain to save a patients life. This vision call...
Unleashing Cellulose Potential: Laser-Driven Structural Modulation
LaserCell envisions an innovative approach to reshape and rearrange cellulose at the molecular level by disrupting cohesive interactions through resonant excitation of specific bon...
Exploring the mechanisms of long-term tumour evolution and genomic instability in marine transmissible cancers
Cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme. Most cancers arise from and remain within the bodies of their respective host ind...
Holistic Rigorous Numerical Verification
My goal is to make rigorous numerical verification widely applicable and practically usable. Rigorous verification proves at compile-time that a program computes for all valid inpu...
VALues and dependence of society on pollinatORs
VALOR is a multi-actor project that will develop a comprehensive systems based approach to develop a deeper understanding of the cascading impacts of pollinator shifts from flower...
Unravelling FRESHwater and ocean Currents changes in the Arctic using REmote sensing
The Arctic is warming rapidly, causing significant hydrographic changes including sea ice retreat, freshwater accumulation, and altered ocean currents. These changes intensify wate...
6G-DALI: 6G DAta and ML operations automation via an end-to-end AI framework
One of the key enablers of 6G is undoubtedly the Native support of AI/ML at all the system levels, components, and mechanisms, from the orchestration and management levels to the l...