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21,042 grants found
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DNA Breaks Shape Neural Genome Heterogeneity
Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain. In neural progenitor cells, replication stress can lead to...
Fast and accurate enantiomeric and chemical analysis
Chiral molecules exist as two forms, called enantiomers, which are mirror images of each other but which are not superimposable. Living organisms are built upon chiral elementary b...
Epigenetic regulation of cell fate during early mammalian development
Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan. Single cell RNA-sequencing has identified majo...
Enantioselective C-H Oxidation Guided by Rational Catalyst Design
Chemo- and enantioselective oxidation of aliphatic C-H bonds is a cornerstone reaction in metabolism. The ubiquitous presence of multiple and diverse C-H bonds in organic molecules...
Engineering Carbon Nanodots for (Nano)Technological and Biomedical Applications
e-DOTS takes advantage of nanoscale and process-intensification principles, information technology and automation/robotics to translate molecular properties to nanoparticles for us...
Note-taking and Notebooks as Channels of Medieval Academic Dissemination across Europe
Note-taking is a common intellectual practice. In academia, it is a universal endeavor that we share with students since the origin of the universities. Yet no one has focused on t...
The Impact of the International Right to Housing on National Legal Discourse: Using Data Science Techniques to Analyse Eviction Litigation
Eviction the involuntary loss of ones home has a devastating impact on peoples wellbeing and has severe consequences for society as a whole. During and after the financial crisis...
Overcoming stellar activity in radial velocity planet searches
Radial velocity (RV) planet searches are a key exoplanet detection method, and one of the only ways to measure a planet's mass. The best RV instruments today reach precisions well...
High Temperature – Small-Scale Sub-Surface Deformation assisted by Oxidation
Structural materials exposed at high temperatures (650C-1200C) and severe loads are prone to both local oxidation-assisted deformation and deformation-assisted surface reactivity....
Public participation by other means? Informal practices to engage with matters of collective concern in non-democratic settings
How to ensure meaningful public participation in governing matters of collective concern? With the growth of distrust and alienation between citizens and established political inst...
Beliefs and Gender Inequality
There are large differences in earnings between men and women. Recent work highlights the importance of parenthood for the existence of gender inequality in the labour market. Esti...
A nationwide artificial intelligence risk assessment for primary prevention of cardiometabolic diseases
Diabetes, stroke and coronary artery disease (cardiometabolic diseases) are the leading cause of death in Europe. Given that effective pharmacological and lifestyle interventions a...
Realizing Leibniz’s Dream: Child Languages as a Mirror of the Mind
Children around the globe acquire language and with it the human ability to communicate complex thoughts. This project develops a new linguistic theory to explain language and its...
Development of an accurate, early diagnostic tool for ovarian cancer
Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced...
Estimation and control under limited information with application to biomedical systems
The goal of this project is to develop estimation and control strategies for systems where only a (very) limited amount of information (measurements and models) is available. The m...
PURism in Antiquity: Theories of Language in Greek Atticist Lexica and their Legacy
Linguistic purism, the attempt to protect language against the threat of multilingualism, change and outside contact, finds an antecedent in Greek Antiquity that remains mostly unk...
Predicting potent drug combinations by exploiting monotherapy resistance
Personalising treatments based on tumour genetic profiles enables cancer precision medicine. However, treating cancers using targeted therapies often fails due to the emergence of...
Commercial feasibility of a therapeutic approach to cancer based on ‘LEGO’ antibody recruiting glycodendrimers
Cancer remains a major cause of mortality worldwide, with projections estimating that 40% of population will be diagnosed with a form of cancer during their lifetime. Despite signi...
Biomechanical Stimulation based on 4D Printed Magneto-Active Polymers
MAPs are polymer-based composites that respond to magnetic fields with large deformation or tuneable mechanical properties. I aim to apply heterogeneous 3D printed MAPs as modifiab...
Pharmacological restoration of selective autophagy for the treatment of skeletal disorders
Lysosomal storage disorders (LSDs) are a family of inherited genetic diseases characterized by lysosomal dysfunction, with a consequent block in the degradative capacity of the cel...