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201,169 grants found
Showing 199,921 – 199,940 of 201,169 grants
Developmental origins and early detection of ADHD and dysregulatory psychopathology
PROJECT SUMMARY: The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral and emotional problems. To do so children are follow...
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr. Lauren Gerlach for a career as an independent investigator focused on measuring and improving the qu...
Impact of brain estrogens on cognition and brain aging in a non-human primate
The goal of the parent grant is to characterize the effects of the aromatase inhibitor letrozole (LET) and the brain-selective estrogen prodrug DHED on (1) behavior; (2) brain el...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA struc...
Exploring cyclic di-nucleotide signaling across the tree of life (Supplement)
I am requesting support for the purchase of an Agilent BioTek LogPhase 600 microbiology plate reader through Notice NOT-GM-24-021 under the parent grant R35 GM139537-01, “Explorin...
Regulatory mechanisms of the Hsp90 chaperone machinery.
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transduction p...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Project Summary: Supplement for $7,016 for purchase of a spectroradiometer Understanding and leveraging molecular diversity within the phytochrome superfamily R35 GM139598; Pri...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process ge...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively in...
EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)
This OT Award funds clinical trials within The Early Phase Pain Investigation Clinical Network (EPPIC-Net). EPPIC-NET is part of the NIH Helping to End Addiction Long-term (HEAL) I...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it. This research wil...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in euk...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learni...
Collaborative Research: AccelNet: Clean Air Monitoring and Solutions Network (CAMS-Net)
Air pollution is causing a global public health crisis, responsible for around 4.9 million premature deaths worldwide each year. Air pollution-related disease and death increasingl...
Mechanics of Active Slide-Ring Networks: from Molecular Motors to Molecular Machine
This grant will focus on understanding how the molecular structure of novel polymers affects their ability to contract - similar to how natural muscles contract and lengthen to gen...
NSF Postdoctoral Fellowship in Biology FY 2020: Mechanisms of sensory reception in the hydrodynamically-adapted skin of cetaceans
<p>This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2020, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, En...
Dimensions US-China: Collaborative Research: Impacts of heritable plant-fungus symbiosis on phylogenetic, genetic and functional diversity.
As primary producers of life, the hundreds of thousands of species of flowering plants are an essential component of Earth’s biodiversity. Interestingly, seeds of flowering plants...
Collaborative Proposal: MRA: Using NEON data to elucidate the ecological effects of global environmental change on phenology across time and space
Global environmental change is causing shifts in species’ phenologies (the timing of ecological processes) and rates of acclimation (physiological adjustments to environmental chan...
ADVANCE Catalyst: Advancing Communities of Equity through Institutional Transformation at St. John's University
The Advancing Communities of Equity through Institutional Transformation (ACE-IT) program at St. John’s University will focus on assessing the climate experienced by minoritized fa...
SenSE: AI-Driven, Resilient and Adaptive Monitoring of Sleep (AI-DReAMS)
A considerable amount of the population in the US and around the world suffers from a chronic sleep disorder. However, the majority of these are not diagnosed or treated. There is...