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201,169 grants found
Showing 199,881 – 199,900 of 201,169 grants
Research Supplements to Promote Diversity in Health-Related Research
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic meth...
Rapid identification and selection of functional antigen-specific monoclonalantibodies by FcGR-enabled screening on CellRaft Arrays in the CellRaft AIRSystem
Project Summary The production of antibodies using hybridoma or primary B-cells with in vitro screening technologies represents one of the most industrialized processes in conte...
Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with the most common manifestation being development of bilateral schwannomas of the 8th cranial nerve (...
Impact of the microbiome on chemotherapeutic outcomes
PROJECT SUMMARY/ABSTRACT Cytotoxic chemotherapeutic agents are a key component of cancer therapy, but they have unpredictable treatment responses and considerable treatment-rela...
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for...
Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations
PROJECT SUMMARY/ABSTRACT The goal of the proposed research training program is to provide tailored additional training to facilitate successful career development throughout the...
Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier
Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computati...
MicroRNA Function During Neuronal Reprogramming in Treating Spinal Cord Injury
Project Summary: One major obstacle in treating spinal cord injury (SCI) is to replenish neurons that are lost during the course of injury and to restore local neuronal circuitry...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistanc...
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispa...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10 years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and p...
Improving the Management of Rheumatoid Arthritis-Associated Lung Disease in Veterans Using Real-World Data
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1.3 million individuals in the U.S., causing physical disability, reduced quality of life, premature mortality,...
A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia
Dr. Elahi is an early career physician-scientist with specialty training in neurodegenerative disease and experience in biomarker development, who seeks to develop her career at t...
Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis
Despite the association between gut microbiota and multiple sclerosis (MS) being increasingly appreciated, the mechanism through which gut bacteria and their metabolites modulate...
Role of skin injury-induced inflammation in wound healing
PROJECT SUMMARY Chronic skin wounds like diabetic foot ulcers (DFU) are a serious medical problem in Veterans. Up to one third of patients with diabetes develop DFU, a leading ca...
Community Care Utilization among Post-9/11 Veterans with Traumatic Brain Injury
Background: Estimates suggest that 20% or more of Post-9/11 Veterans have experienced at least one military-related traumatic brain injury (TBI); the majority are categorized as m...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologi...
Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy
Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large establ...
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
PROJECT SUMMARY Aging is the primary risk factor for mild cognitive impairment (MCI), Alzheimer’s disease and related dementias. Cerebrovascular dysfunction (i.e., reduced cerebr...