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201,169 grants found
Showing 199,861 – 199,880 of 201,169 grants
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deter...
Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application
Abstract The lung is a natural tolerogenic organ. Lung mucosal tolerance must be exquisitely controlled by the lung immune system to avoid the development of chronic inflammatory...
Developing computational algorithms for histopathological image analysis
Project Summary Histopathology is the cornerstone of disease diagnosis and prognosis. With the advance of imaging technology, whole-slide image (WSI) scanning of tissue slides i...
Iowa StARR Scholars Program
PROJECT SUMMARY The Iowa StARR Scholars Program is designed to help address the continuing need for physician-scientists in the fields of internal medicine and pediatrics. The Un...
1/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa pop...
Examining the role of the neighborhood environment on muscle function in older adults
PROJECT SUMMARY/ABSTRACT Poor muscle function is a pressing public health problem: half of all U.S. older adults meet criteria for muscle weakness. Poor muscle function, defined...
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage
Abstract Subarachnoid hemorrhage (SAH) accounts for 5% of all strokes, has a high mortality and the cost to society is similar to ischemic stroke since subjects are much younger....
Tulane StARR Program
PROGRAM SUMMARY This is the first renewal application for the Tulane StARR Program which successfully recruited a diverse cadre of 6 StARR Scholars who are actively engaged in me...
Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain with Psychological Comorbidity
Chronic pain (CP), defined as persistent (>6 months), non-malignant, musculoskeletal or generalized pain, is a prevalent and costly public health problem. CP is highly prevalent a...
Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy
Our overarching hypothesis is that senescent stromal fibroblasts, especially if they elicit an inflammatory response, promote progression to lethal disease in men with prostate ca...
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr. Lauren Gerlach for a career as an independent investigator focused on measuring and improving the qu...
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA‐approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly...
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment o...
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.
Parkinson’s Disease (PD) is a common neurodegenerative disorder affecting human movements. PD is not just a motor disease. It also results in impaired multi-sensory processing tha...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer’s disease (AD) is characterized by heterogeneity in sex, race, APOE ε4 status, and tau. APOE ε4 status has been used to stratify AD patients in...
Measuring Whole and Tissue Level Bone Strength in men
Abstract Most patients who fracture have non-osteoporotic bone mineral density. Often, the result of a fracture is devastating and results in substantial morbidity and health car...
Telehealth to Improve Prevention of Suicide (TIPS) in EDs
ABSTRACT Significance: Our study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor...
Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human Brain
PROJECT SUMMARY/ABSTRACT Anxiety is a common symptom across psychiatric disorders and is associated with worse quality of life and impairment. However, the existing treatments fo...
Discovery and development of artificial nucleic acid ligands to probe cellular interactions
Discovery and development of artificial nucleic acid ligands to probe cellular interactions The regulation followed by measurement of cellular events, such as intercellular commun...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)—the only randomized controlled trial (RCT) comparing foster care to institutional care for young children...