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201,169 grants found
Showing 199,841 – 199,860 of 201,169 grants
Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program
Project Abstract Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status househo...
Deep learning models to predict primitive streak formation in human development
Project Summary Congenital birth defects affect an estimated 3% of live births. To develop effective treatment strategies, a thorough understanding of early human development is...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tu...
Next generation deep tissue quantitative optical imaging
PROJECT SUMMARY Nearly 20 years of clinical research has shown that near-infrared optical imaging based upon frequency domain diffuse optical spectroscopy (FD-DOS) can be a power...
Mechanisms regulating neural stem cell maintenance in the dentate gyrus
Project Summary Dr. Bond’s primary career goal is to run her own independent academic research group broadly investigating how principles of brain development can be used to unde...
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate Eye
The importance for vision of the tiny fovea has been established by centuries of investigation as well as observations of the devastating consequences of its damage through injury...
Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers
Abstract Extracellular vesicles (EVs) are membranous particles released from nearly all cell types into all bodily fluids evaluated to date — including serum and plasma. Dependin...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide. SCC prognosis is context-dependent and does not seem to be determined by driver gene som...
Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
Multiple hypotheses have been put forward regarding cortical circuit dysfunction in autism, including: excitation to inhibition (E/I) imbalance, hyper- or hypo- connectivity profi...
Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery system
Gene silencing using small interfering RNA (siRNA) is a viable therapeutic approach but, limited in translation due to lack of effective delivery systems. Developing effective and...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk fact...
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
Project Summary Many long-term survivors of cancer experience progressive chemotherapy-induced cognitive impairment (CICI, commonly referred to as "chemobrain"). Importantly, no...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new appro...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
PROJECT SUMMARY Early detection of lung cancer among asymptomatic individuals is a priority for reducing mortality of the number one cancer killer worldwide. Most lung cancers ar...
A First-in-Class FAP-activated Protoxin to disrupt the Tumor-Stroma Parasitic Cycle fueling lethal Prostate Cancer Progression
Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC). Additionally, the propo...
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
Project Summary The vast majority of cardiovascular diseases (CVD) occur in men and women ≥60 years of age. Changes in the demographics of aging in the U.S. predict progressive...
Learning principles from the pyrenoid, a phase-separated organelle
PROJECT ABSTRACT Phase separation is an emerging organizing principle for intracellular biology. Processes that are now understood to exploit phase separation include storage of...
Optimizing sleep spindle measurements as translational assays of memory consolidation
This research proposal addresses a key challenge to drug development: the paucity of biomarkers that reveal whether interventions affect implicated brain circuitry at early stages...
Renal AT2 Receptors in Hypertension
PROJECT SUMMARY/ABSTRACT Hypertension (HT) affects ~48% of the US population. Increased renal sodium (Na+) retention is a major contributor to the development of HT. The renal an...
Ligand discovery for delineating cholesterol homeostasis in the brain
Alzheimer’s disease (AD) is a long-term neurodegenerative disorder that ranks sixth in the leading cause of all deaths in the United States and features amyloid β protein depositio...