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201,169 grants found
Showing 321 – 340 of 201,169 grants
Harvard Clinical and Translational Science Center
PROJECT SUMMARY/ ABSTRACT Clinical and translational research (CTR) across Harvard is conducted at 17 independent and geographically dispersed institutions, including Harvard Med...
Harvard Clinical and Translational Science Center
PROJECT SUMMARY/ ABSTRACT Clinical and translational research (CTR) across Harvard is conducted at 17 independent and geographically dispersed institutions, including Harvard Med...
A non-viral CRISPR-mediated genome editing delivery platform as a potential therapy for neurogenetic diseases
Genome editing holds great promise for the treatment of many genetic diseases; however its application in the clinic has been slow due to the lack of the safe delivery tools and s...
Children's Oncology Group Statistics and Data Center
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically...
The Event Horizon Telescope: Resolving Black Holes in Time and Space
Black holes are the most mysterious objects in the cosmos. They are formed when matter collapses in on itself under the force of gravity, producing a singularity of infinite densit...
Adult Changes in Thought (ACT) Research Program
The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults i...
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies
ABSTRACT: Cognition Therapeutics, Inc. (CogRx) is developing CT1812 for neurodegenerative conditions, including Dementia with Lewy Bodies (DLB). This first-in-class small molecule...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population....
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
PROJECT SUMMARY In this proposal we aim to identify gene regulatory elements that permit the targeting and manipulation of brain circuit models of human brain function. Gaining g...
Research Infrastructure: Mid-scale RI-1 (M1:IP): Creating an Offshore Subduction Zone Observatory in Cascadia with the Ocean Observatories Initiative Regional Cabled Array
Earth’s greatest geological hazards are concentrated in its subduction zones, the places where two tectonic plates converge and collide. All known earthquakes with magnitudes ≥8.8...
Iron-CLAD: securely advancing AoU participant characterization with provenplatforms and collaborations
ABSTRACT Precision medicine aims to accurately classify patients to improve diagnosis, intervention selection, and prognosis. The All of Us Research Program (AoURP) collects a di...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population....
The Participant Center: Empowering All of Us Research Program participation across the United States
A. Abstract The Participant Center (TPC) will 1) maintain capabilities that enable full All of Us Research Program (All of Us) participation across the United States (US) and 2)...
BioFoundry: Artificial Intelligence-Driven RNA BioFoundry
The Artificial Intelligence-driven RNA BioFoundry (AIRFoundry) addresses critical challenges in RNA technology research by establishing a user-friendly, open-access platform. This...
Design and Development of a Pan-betacoronavirus Vaccine
Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000...
Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center
Adolescents and young adults (AYA) under the age of 25 in the United States (US) are the least likely of all age groups to: 1) know their HIV status, 2) initiate PrEP if HIV-negat...
ED-LEAD: Emergency Departments LEading the transformation of Alzheimer's and Dementia care
PROJECT SUMMARY In persons living with dementia (PLWD), an Emergency Department (ED) visit is a critical event and an opportunity to address the unmet needs that preceded the vis...
WoU-MMA: IceCube Data Analysis in the U.S. 2022-2025
This award provides funding for U.S. scientists to perform the scientific analysis of data taken with the IceCube Neutrino Observatory (ICNO) located at the U.S. Amundsen-Scott Sou...
BII: Uncovering mechanisms of amphibian resilience to global change from molecules to landscapes
Paramount to predicting the future of biodiversity is knowing when and how living systems are resilient to (i.e., can recover from) anthropogenic disturbances. The focus of this Bi...
Clinical and Translational Science Award
Contact PD/PI: Reilly, Muredach P OVERALL: PROJECT SUMMARY/ABSTRACT Our mission is to improve the health of our patients and communities both locally and nationally through inno...