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201,169 grants found
Showing 201,121 – 201,140 of 201,169 grants
Development of Glypican-2 redirected T cells for the Treatment of Neuroblastoma
Project Summary The objective of this proposal is to develop a T cell-based immunotherapy for the treatment of high-risk neuroblastoma (NB), for which outcomes remain poor. The ado...
Role of skin injury-induced inflammation in wound healing
PROJECT SUMMARY Chronic skin wounds like diabetic foot ulcers (DFU) are a serious medical problem in Veterans. Up to one third of patients with diabetes develop DFU, a leading caus...
Improving the Management of Rheumatoid Arthritis-Associated Lung Disease in Veterans Using Real-World Data
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1.3 million individuals in the U.S., causing physical disability, reduced quality of life, premature mortality,...
Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis
Despite the association between gut microbiota and multiple sclerosis (MS) being increasingly appreciated, the mechanism through which gut bacteria and their metabolites modulate d...
Reprogramming of type 2 alveolar epithelial cells in idiopathic pulmonary fibrosis and regulation by TGFb1.
Idiopathic Pulmonary Fibrosis (IPF) is the most common fibrotic interstitial lung disease among adults. The cause of IPF is not fully understood, and it is frequently progressive,...
IL-1Beta-Induced Retinal Iron Accumulation in Age-Related Macular Degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the United States. AMD is characterized by the death of photoreceptors...
CD25-mediated feedback control of BCR-signaling and its oncogenic mimics
PROJECT SUMMARY B cells critically depend on continuous survival and proliferation signals from a functional B cell receptor (BCR). Likewise, in ~50% of B cell malignancies, the tu...
Rhythmogenic states of the respiratory network reveal differential opioid sensitivity
PROJECT SUMMARY Opioid induced respiratory depression (OIRD) is the major cause of death associated with opioid use and drugs of abuse. Although the mortality risk increases in a d...
MicroRNA Function During Neuronal Reprogramming in Treating Spinal Cord Injury
Project Summary: One major obstacle in treating spinal cord injury (SCI) is to replenish neurons that are lost during the course of injury and to restore local neuronal circuitry f...
Network-based algorithms for target identification and drug repositioning from genetic associations
In the field of genetics, genome-wide association studies of common variants (GWAS) and exome sequencing- based analyses are a common strategy to elucidate the relationship between...
Traumatic Axonopathy in the CNS as Wallerian degeneration
PROJECT SUMMARY In this application we propose that traumatic axonal injury (TAI) leads to an active axonopathy with the molecular features of Wallerian degeneration and that targe...
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
Project Summary/Abstract Calcium activated Chloride Channels (CaCCs) and other TMEM16 family members form ion channels and/or lipid scramblases that help orchestrate a large number...
PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping
Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally. However, a vital step for EHR-based research is valid, accurate, and reliable...
Assessing the Influence of the Human Lipidome on Risk of Diabetes in a Minority Population
PROJECT SUMMARY Type 2 diabetes is a major public health concern. Diabetes currently affects 25.8 million people in the US alone and 90-95% of all cases are type 2. There are many...
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)
SARS-CoV-2 (SARS2) infection, which leads to COVID-19, is a global pandemic. Chronic lung disease (CLD), particularly chronic obstructive pulmonary disease (COPD), has emerged as a...
Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal Cord
Injury to the cervical spinal cord results in an immediate and permanent loss of hand function due to massive disruption of neural circuitry. There are currently no effective thera...
Exploiting sex-dependent brain injury response for nanoparticle therapeutics
Abstract Traumatic brain injury (TBI) afflicts over 1.7 million persons per year in the U.S. alone, resulting in substantial economic burden annually. To date, despite promising pr...
Telehealth to Improve Prevention of Suicide (TIPS) in EDs
ABSTRACT Significance: Our study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor ac...
Intermuscular coherence: A novel biomarker for upper motor neuron dysfunction in ALS
Project Summary/Abstract Amyotrophic lateral sclerosis (ALS) is a uniformly fatal neurodegenerative disease caused by neuronal death in the motor system, both in the brain and spin...
A First-in-Class FAP-activated Protoxin to disrupt the Tumor-Stroma Parasitic Cycle fueling lethal Prostate Cancer Progression
Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC). Additionally, the propor...