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201,169 grants found
Showing 201,121 – 201,140 of 201,169 grants
Real-time Infection Prediction in Inpatient Postoperative Care
Postoperative infections are the most common surgical complication, affecting upwards of 40 Veterans each day and adding an estimated $25,000 to the total cost of care per infectio...
Mechanistic studies of Neurosteroid Analogues
Project Summary Neurosteroids such as allopregnanolone (AlloP) strongly potentiate GABAA receptor function, driving the view that these effects mediate psychoactive effects of neur...
Elucidating the Mechanisms Mediating the Impact of Neuroactive Steroids on Network and Behavioral States
Project Summary Many psychiatric illnesses are characterized by episodes of behavioral disruption. The current project attempts to understand the mechanisms mediating transitions b...
Chemistry Core
Abstract The center uses novel strategies to determine the mechanism(s) of action for the anti- depressant actions of neurosteroids. A panel of neurosteroid analogues with a range...
Administrative Core
Abstract The Administrative Core of the Cincinnati Cooperative Center of Excellence in Hematology (CCCEH) is anchored in the Division of Experimental Hematology at Cincinnati Child...
Xenotransplant and Genome Editing Core
Abstract Genetically modified and immunocompromised animals are the gold-standard models for investigating the molecular regulation of hematopoietic cells in the context of normal...
Single Cell Characterization and Procurement Core
SCCPC Abstract As a direct result of our ability to analyze hematopoietic cells at the single cell level, our understanding of the complexity and heterogeneity of the hematopoietic...
Gene Delivery Core
Abstract Investigation of the molecular and cellular pathophysiology for hematologic diseases requires rapid and low-cost access to vector preparations, and access to large librari...
Enrichment
Abstract A fundamental goal of the Cincinnati Cooperative Center of Excellence in Hematology (CCCEH) is to facilitate scientific exchange and sharing of techniques, resources, and...
Core C: University of Kentucky Alzheimer's Disease Core Center
Project Summary/Abstract: Data Management and Statistics Core The Data Management and Statistics (DMS) Core can be conceptualized as the lynchpin for integration of the ADRC Cores...
Core D: University of Kentucky Alzheimer's Disease Core Center
Project Summary/Abstract: Neuropathology Core The overall objective of the Neuropathology Core of the UK-ADRC is to support research on normal brain aging, presymptomatic AD, MCI,...
Core E: University of Kentucky Alzheimer's Disease Core Center
Project Summary/Abstract: Outreach, Recruitment and Engagement Core The Outreach, Recruitment and Engagement (ORE) Core plays a central role in achieving UK-ADRC goals by functioni...
Core F: University of Kentucky Alzheimer's Disease Core Center
Project Summary/Abstract: Biomarker Core The theme of our UK-ADRC is Transitions from normal to late-life multi-etiology dementia, and the role of the Biomarker Core is to provide...
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
ABSTRACT ? PROJECT 3 Endometriosis is a common, estrogen-dependent, inflammatory disorder that causes debilitating chronic pelvic pain including severe dysmenorrhea and dyspareunia...
Improving Self-Management and Physical Activity in Teens
This project addresses a key public health issue: the prevention of health disparities in cardiovascular disease and diabetes-related morbidity and mortality in adolescents with t...
Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program
Background: Surgery can precipitate the development of both chronic pain and long-term opioid use. Preoperative psychological distress is a risk factor for poor post-surgical outc...
Administrative Core: Biomolecular Structure and Dynamics
The defining role of the Administrative (Admin) Core of the Center for Biomolecular Structure and Dynamics (CBSD) during phase III COBRE funding is to provide the framework that g...
Integrated Structural Biology Core
The Integrated Structural Biology Core (ISBC) facility of the Center for Biomolecular Structure and Dynamics (CBSD) provides technology and expertise to assist University of Monta...
BioSpectroscopy Research Laboratory
The BioSpectroscopy Core Research Laboratory (BCRL) of the Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) provides investigators with stat...
Optimized Gene Replacement for AAT deficiency and Modeling of Clinical Outcomes in small and large animal models
Project Summary (Project 1) Alpha-1 antitrypsin deficiency (AATD) is a common single gene disorder caused by mutations in the SERPINA1 gene, which normally encodes a very abundant...