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201,169 grants found
Showing 201,081 – 201,100 of 201,169 grants
Administrative Core
CORE SUMMARY / ABSTRACT The Administrative Core will manage the budgetary, administrative, and communication aspects of this Program. The Core will be responsible for coordinatin...
Core A: Elucidating the Mechanisms Underlying Mixed-Chimerism Based Tolerance
CORE SUMMARY / ABSTRACT Tolerance of kidney allografts has been achieved in monkeys and patients via transient mixed hematopoietic chimerism. However, until now, our current mixe...
Project 1: Augmenting Regulatory Mechanisms in Protocols of Transient Mixed Chimerism
PROJECT SUMMARY / ABSTRACT Induction of immune tolerance is the ultimate goal in the field of organ transplantation. Achieving a state of tolerance would lead to indefinite graft...
Project 2: Next-Generation Mixed Chimerism Induction for Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT Heart transplantation represents the best therapeutic option for patients with end-stage cardiac disease. However, while one-year success rates are rea...
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT The unifying goal of this Program is to design new and innovative strategies that achieve clinically-relevant heart allograft tolerance in 2-month-dela...
Xenotransplant and Genome Editing Core
Abstract Genetically modified and immunocompromised animals are the gold-standard models for investigating the molecular regulation of hematopoietic cells in the context of norma...
Single Cell Characterization and Procurement Core
SCCPC Abstract As a direct result of our ability to analyze hematopoietic cells at the single cell level, our understanding of the complexity and heterogeneity of the hematopoiet...
Administrative Core (Core A)
ABSTRACT – CORE A The Administrative Core (Core A) will be the central hub of our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Outreach (E...
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT – PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infe...
Administrative Core
PROJECT SUMMARY/ABSTRACT Administrative Core The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising t...
Research Bronchoscopy and Biospecimens Core
PROJECT SUMMARY/ABSTRACT Core B: Bronchoscopy and Biospecimens The goal of this core is four-fold. First, the core is responsible for performing bronchoscopy on study subjects t...
Severe Asthma Clinical Studies Core
PROJECT SUMMARY/ABSTRACT Core C The Clinical Studies Core is an integral component of the PPG as it is designed to facilitate the conduct of clinical trials outlined in the thre...
Primary Human Airway Cell Culture Core
PROJECT SUMMARY/ABSTRACT Core D Cell Culture The goal of the work described in this proposal is to collect grow, store and expand airway epithelial cells and smooth muscle cells...
Administration Core
ADMINISTRATIVE CORE – PROJECT SUMMARY The Administrative Core will provide day-to-day support for the Center Directors and Project Leaders, and will help to coordinate all activi...
Molecular Targets of Neurosteroid Anti-depressant Action
Project description Neuroactive steroids (NAS) are important modulators of neuronal excitability with demonstrated therapeutic efficacy as anesthetics and rapidly acting anti-dep...
Mechanistic studies of Neurosteroid Analogues
Project Summary Neurosteroids such as allopregnanolone (AlloP) strongly potentiate GABAA receptor function, driving the view that these effects mediate psychoactive effects of ne...
Elucidating the Mechanisms Mediating the Impact of Neuroactive Steroids on Network and Behavioral States
Project Summary Many psychiatric illnesses are characterized by episodes of behavioral disruption. The current project attempts to understand the mechanisms mediating transitions...
Chemistry Core
Abstract The center uses novel strategies to determine the mechanism(s) of action for the anti- depressant actions of neurosteroids. A panel of neurosteroid analogues with a rang...
A biomarker for personalized care in post-stroke spatial neglect
This SPiRE provides the opportunity to raise the technical expertise of the PI (Barrett), and provide a critical missing element for personalized rehabilitation care in spatial ne...
Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program
Background: Surgery can precipitate the development of both chronic pain and long-term opioid use. Preoperative psychological distress is a risk factor for poor post-surgical outc...