Browse All Grants
201,169 grants found
Showing 201,081 – 201,100 of 201,169 grants
Tracking the dynamics of how schemas scaffold recall
Project Summary Every new experience in our life takes place within the context of familiar environments and situations. However, most research on memory has focused on the artific...
Small Molecule KLF15 Agonists for Kidney Disease
The Centers for Disease Control and Prevention estimates more than 15% of adults in the United States, over 30 million Americans have chronic kidney disease (CKD). Podocytes are ep...
Lung Innate COVID-19 Defense Specific to Veterans Risk Characteristics
COVID-19 is now a global pandemic requiring a rapid and concerted response from the scientific and medical community. Based upon recent epidemiology derived only months earlier fro...
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive Tract
Project Summary Exposure to persistent environmental toxicants (such as dioxin) is a global problem, but disproportionately affects Veterans who were exposed dioxin derived from bu...
Defining the Role of Microglia in the Synaptic Rewiring of the Hypothalamus by Early life Adversity
PROJECT SUMMARY:Early-life adversity can profoundly impact an individual’s risk for stress-related emotional disorders including depression, likely by modulating the maturation of...
Racial/Ethnic Differences in Social Support and Health Among Individuals with Type 2 Diabetes
PROJECT SUMMARY/ABSTRACT About 1 in 10 people in the United States are currently affected by diabetes, an illness that demands constant self-management with respect to diet, physic...
Sleep and Word Learning Over Time in Adults with Moderate-Severe Traumatic Brain Injury
PROJECT SUMMARY Word learning relies heavily on memory systems and processes that are routinely impaired in traumatic brain injury (TBI) (e.g., the declarative memory system). The...
Community Care Utilization among Post-9/11 Veterans with Traumatic Brain Injury
Background: Estimates suggest that 20% or more of Post-9/11 Veterans have experienced at least one military-related traumatic brain injury (TBI); the majority are categorized as mi...
Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials
Project Summary The project addresses a common challenge in the remediation of groundwater contaminated with chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane. CVOCs i...
The role of multiciliated cell dysfunction in pathogenesis of IPF
Project Summary/ Abstract The goal of this proposal is to determine if mucociliary clearance (MCC) dysfunction in idiopathic pulmonary fibrosis (IPF) is due to abnormal multiciliat...
Emotion Regulation Flexibility and Suicide Risk
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death for adolescents and young adults, with rates of suicide deaths rising in the past two decades. Research examin...
Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)
PROJECT SUMMARY Environmental contamination by per- and polyfluoroalkyl substances (PFASs) is a major public health concern because of the wide range of toxic effects that have bee...
COVID-19: Understanding The Role of Corona Virus InducedDisruption Of Alveolar Type 2 Cell Function And SurfactantHomeostasis In The Pathogenesis Of COVID-19 AcuteRespiratory Distress Syndrome
ABSTRACT The Severe Acute Respiratory Syndrome (SARS)-associated coronavirus 2 (SCoV2) is the cause of COVID-19 syndrome which is marked by a refractory acute lung injury that resu...
Deciphering the Relationship Between Cardiomyocyte Metabolic Configuration and Cell Cycle Re-entry
Myocardial infarction causes irreversible loss of cardiomyocytes (CMs) and often leads to heart failure. To replace the lost cells, we identified a combination of cell-cycle regula...
Role of the ETV6 transcription factor in hematopoietic stem cell function
PROJECT SUMMARY Hematopoietic stem and progenitor cells (HSPCs) are at the root of the hematopoietic system and must give rise to all blood cells while also being prepared to respo...
Developmental origins and early detection of ADHD and dysregulatory psychopathology
PROJECT SUMMARY: The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral andemotional problems. To do so children are followed...
Applying and advancing modern approaches for studying the joint impacts of environmental chemicals on pregnancy outcomes
Preterm birth is a significant public health challenge due to increasing rates over time, as well as serious consequences for infant mortality, childhood morbidity, and economic co...
The Epitranscriptome as a Novel Mechanism of Arsenic-Induced Diabetes.
SUMMARY In the United States, the prevalence of type 2 diabetes mellitus (T2DM) is particularly high among American Indian (AI) communities. Arsenic (As), a pervasive environmental...
Understanding the intestinal regenerative response using patterned organoids in photo-tunable PEG hydrogels
Project Summary Nonspecific targeting of highly proliferative, non-cancerous cell types during chemotherapy highlights the limitations of these treatment modalities. In the intesti...
Dissecting the role of neural inputs in the regulation of AgRP neurons
Project Abstract: Proper regulation of food intake is essential for survival to prevent over- or under-feeding. Sensory signals generated by the detection and consumption of food c...