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201,169 grants found
Showing 201,041 – 201,060 of 201,169 grants
Androgen signaling in asthma
PROJECT SUMMARY/ABSTRACT Asthma is a sexually dimorphic disease, with women exhibiting higher asthma prevalence and more severe manifestations than men. Projects 3 builds upon th...
Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.
Project Summary/Abstract Anxiety disorders cause significant distress on a personal level, and cost > $40,000,000,000 annually in the United States alone. They are common, with...
Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.
Project Summary/Abstract Anxiety disorders cause significant distress on a personal level, and cost > $40,000,000,000 annually in the United States alone. They are common, with...
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: ADMINISTRATIVE CORE The overarching goal of the Administrative Core is to provide the operational support necessary to successfully achieve the goals we have laid out f...
Data Management and Analysis Core (DMAC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: DATA MANAGEMENT AND ANALYTICS CORE (DMAC) Data Management and Analytics Core (DMAC) and the overall goals that provide support to the Scientific Human Biomarker Exposur...
Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: PROJECT 1 Air pollution, particularly particulate matter <2.5µm (PM2.5) comprising a variety of organic molecules produced by combustion, is a significant driver of chr...
Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study
ABSTRACT: PROJECT 2 Lung and cardiac diseases are complex disorders with underlying chronic inflammation, which can be induced or worsened by exposure to air pollution. Thus, und...
Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in
ABSTRACT: PROJECT 3 Air pollution, particularly particulate matter <2.5µm (PM2.5), penetrates into lung passageways and enters the bloodstream, causing respiratory, cardiovascula...
Administrative Core (Core A)
ABSTRACT – CORE A The Administrative Core (Core A) will be the central hub of our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Outreach (E...
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT – PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infe...
Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis
ABSTRACT – PROJECT 2 Approximately 10% of reproductive-aged women are diagnosed with endometriosis, an inflammatory, estrogen- dependent disorder characterized by endometrial tis...
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
ABSTRACT – PROJECT 3 Endometriosis is a common, estrogen-dependent, inflammatory disorder that causes debilitating chronic pelvic pain including severe dysmenorrhea and dyspareun...
Education and Community Engagement Core (Core B)
ABSTRACT – CORE B The goal of the Educational Outreach Core (Core B) in our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT...
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
ABSTRACT (Project 1) Pancreatic ductal adenocarcinoma (PDAC) is a prevalent and almost uniformly fatal malignancy. Human PDAC genome sequencing has identified recurrent mutations...
Project 2: Immune signals promoting pancreas cancer stemness and progression
ABSTRACT (Project 2) There is an urgent need to discover improved therapies for pancreatic ductal adenocarcinoma (PDAC), which require a better understanding of mechanisms unde...
Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapy
ABSTRACT (Project 3) Pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy that is poorly responsive to treatment, is characterized by a prominent infiltration of imm...
Administrative and Biostatistics Core
ABSTRACT (Core A-Administrative and Biostatistics Core) This application seeks support for its efforts to discover, apply, and translate scientific knowledge about pancreatic c...
Core B: Human Pancreas
ABSTRACT: Stanford Human Bio-bank for Pancreas Cancer Research (Core B) The Stanford Human Bio-Bank for Pancreas Cancer Research (Core B) will support human tissue and cell stud...
Core C: CODEX Core
ABSTRACT (Core C) A central focus of our program is understanding the roles of specific cell types, including immune cell populations, throughout the initiation, development and...
Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program
Background: Surgery can precipitate the development of both chronic pain and long-term opioid use. Preoperative psychological distress is a risk factor for poor post-surgical outc...