Browse All Grants
201,169 grants found
Showing 201,001 – 201,020 of 201,169 grants
Comprehensive mapping of multimodal chromatin state in single cells
PROJECT SUMMARY Many non-Mendelian (polygenic) human genetic diseases involve multiple causal loci in noncoding regions of the genome, implicating mutations in regulatory element...
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
Project Summary Many long-term survivors of cancer experience progressive chemotherapy-induced cognitive impairment (CICI, commonly referred to as "chemobrain"). Importantly, no...
Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery system
Gene silencing using small interfering RNA (siRNA) is a viable therapeutic approach but, limited in translation due to lack of effective delivery systems. Developing effective and...
A versatile "pan-spike-in" internal reference genome methodology for quantitative ChIP-seq normalization
Project summary: ChIP-seq has enabled the mapping of genomic occupancy of many chromatin factors and epigenetic histone modifications, linked to normal growth and development and...
Applying and advancing modern approaches for studying the joint impacts of environmental chemicals on pregnancy outcomes
Preterm birth is a significant public health challenge due to increasing rates over time, as well as serious consequences for infant mortality, childhood morbidity, and economic c...
Assessing the Influence of the Human Lipidome on Risk of Diabetes in a Minority Population
PROJECT SUMMARY Type 2 diabetes is a major public health concern. Diabetes currently affects 25.8 million people in the US alone and 90-95% of all cases are type 2. There are man...
Defining the role of Mst1/Mst2 in regulating metabolic alterations in Ras driven NSCLC
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) remains the most commonly diagnosed malignancy and leading cause of cancer related deaths worldwide; yet there is a fu...
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
PROJECT SUMMARY/ABSTRACT Head and Neck Squamous Cell Carcinomas (HNSCCs) are devastating upper airway tumors that are associated with an immunosuppressive network impacting the t...
Therapeutic Targeting Mitochondrial C1 Metabolism
ABSTRACT Metabolic reprogramming is an important hallmark of cancer. Of the altered metabolic pathways associated with malignancy, one-carbon (C1) metabolism is particularly nota...
DEHART: Dose-Escalated Hypofractionated Adaptive Radiation Therapy for Head and Neck Cancers
Abstract Locoregional failure remains the principal mode of mortality in head and neck squamous cell carcinomas (HNSCCs) treated with conventional chemoradiation therapy over 7 w...
Role of MIF and CD74 in the pathogenesis of emphysema
PROJECT SUMMARY Emphysema is a common pathologic manifestation of Chronic Obstructive Pulmonary Disease (COPD), the fourth leading cause of death in the United States. The most i...
Discovery and development of artificial nucleic acid ligands to probe cellular interactions
Discovery and development of artificial nucleic acid ligands to probe cellular interactions The regulation followed by measurement of cellular events, such as intercellular commun...
Understanding and Targeting Tiam1 in Cancer
Project Summary: Understanding the detailed mechanisms that underlie proliferative signal transduction pathways is of critical importance for developing strategies for diagnosis...
Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer
Project Summary. The goal of this project is to develop, optimize, and evaluate an artificial intelligence (AI)- driven, medical imaging platform that utilizes computed tomography...
Studies of the structural and functional basis of neuroblastoma drug resistance
PROJECT SUMMARY/ABSTRACT Neuroblastoma is the most common extracranial tumor of young children, and the five-year overall survival of children with high-risk disease is less tha...
Mixed methods analysis of perceived social status and its influence on oral health
PROJECT SUMMARY/ABSTRACT Background and Candidate: Oral health disparities are significant in the United States and despite considerable advances in prevention, diagnosis, and tr...
The molecular mechanism and the functional role of pyruvate dehydrogenase complex regulation in macrophages
PROJECT SUMMARY: Precise control of innate immunity is critical for human health. Both insufficient or excess inflammation can have detrimental effects and both are related to a...
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common pediatric kidney cancer. Blastemal-predominant tumors are classified as high-risk and have demonstrated resistance to che...
Proteomic discovery and characterization of chemical tools that degrade the NuRD chromatin regulatory complex
Project Summary As virtually all aspects of cell behavior and identity converge upon programmed responses in gene expression, transcriptional control features centrally in both n...
Role and regulation of a peptidoglycan synthesis enzyme required for cephalosporin resistance in enterococci
PROJECT SUMMARY/ABSTRACT: Infective endocarditis, a condition in which bacteria grow in a biofilm-like state on the valves of the heart, is a deadly complication of bloodstream i...