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201,169 grants found
Showing 200,981 – 201,000 of 201,169 grants
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births. Major subsets of congenital heart defects a...
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
Project Summary Physical inactivity is a public health priority for older Latinos with mild cognitive impairment (MCI). MCI, considered the pre-dementia stage of Alzheimer’s dise...
Behavioral and neural properties of spatial direction comprehension in aging and amestic mild cognitive impairment
Project Summary: Spatial navigation is an essential task for living a safe, independent life. Spatial navigation skills decline in normal aging and become progressively impaired i...
Allorecognition, parasitic stem cells and regeneration in a basal chordate
Abstract Our lab works at the intersection of immunology, stem cell biology and regeneration, and the grants funding this work (GM123267 and GM 123255) which we are requesting to...
The Mid-Atlantic Neuroscience Diversity Scholars (MINDS) Program
PROJECT SUMMARY/ABSTRACT This application is a five-year plan to create a Mid-Atlantic Neuroscience Diversity Scholars (MiNDS) program to bolster the number of underrepresented m...
In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET
PROJECT ABSTRACT Exposure to repetitive head impacts (RHI) through participation in contact sports can result in symptomatic concussions and asymptomatic sub-concussions and may...
Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementia
PROJECT SUMMARY/ABSTRACT Appropriate use of acetylcholinesterase (AChEIs) and memantine can meaningfully improve the health outcomes and quality of life among people with Alzheim...
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr. Lauren Gerlach for a career as an independent investigator focused on measuring and improving the qu...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early...
MMACHC Regulates Craniofacial Development
cblC is a multiple congenital anomaly syndrome caused by mutations in the MMACHC gene. cblC is characterized by defects in cobalamin (vitamin B12) metabolism, but mild to moderate...
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
ABSTRACT - In the post-ischemic heart, relatively little is known about the injured-but-not-infarcted myocardium, which we call the intermediate zone as it is neither normal nor i...
Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies
Catheter associated urinary tract infection (CAUTI) is one of the most common healthcare-associated infections (HAIs), with a prevalence of 13 – 15% in the United States. CAUTIs a...
Human Factors of Aging Program
Abstract: The candidate, Mark S Redfern, PhD, is a professor at the University of Pittsburgh with a primary appointment in the Department of Bioengineering, Swanson School of Engi...
Protein Kinase Novel 2 (PKN2) in heart
PROJECT SUMMARY The Protein Kinase Novel (PKNs) family of kinases, also known as Protein Kinase C-related kinases, belong to the PKC superfamily. A single nucleotide polymorphism...
Optimizing sleep spindle measurements as translational assays of memory consolidation
This research proposal addresses a key challenge to drug development: the paucity of biomarkers that reveal whether interventions affect implicated brain circuitry at early stages...
The role of Bik in the replication and severity of influenza A virus
Influenza A virus (IAV) is responsible for seasonal epidemics that results in severe respiratory illness and deaths worldwide, costing billions of dollars annually in the U.S. alo...
Sensing Dietary Amino Acids from Gut to Brain
ABSTRACT Proper weight management mandates consistent consumption of nutritionally balanced diets. Consumption of diets insufficient in amino acids leads to weight loss, muscular...
Structural and Functional Studies of HER Receptors
PROJECT SUMMARY/ABSTRACT Receptor tyrosine kinases (RTKs) are activated by extracellular ligands to transduce the bulk of the signals that control cellular growth, proliferation...
Ceramide-Rich Platforms Functionalize Gemcitabine Uptake
Our data indicate that in select settings activation of acid sphingomyelinase (ASMase)/ceramide signaling in tumor endothelial cells by radiation and certain chemotherapies synerg...