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201,169 grants found
Showing 200,961 – 200,980 of 201,169 grants
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
Project Summary The anti-angiogenic agent bevacizumab (BEV) is one of the most effective forms of biologic therapy developed thus far for cervical cancer (CC). However, response...
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7. PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduce...
SCH: Context-aware Freezing of Gait mitigation in real-world setting
See attached. RELEVANCE (See instructions): See attached.
Elucidating mechanisms for enhanced anaerobic bioremediation in the presence of carbonaceous materials using an integrated material science and molecular microbial ecology approach
PROJECT SUMMARY: Halogenated compounds, including legacy pollutants (e.g., chlorinated ethenes (CEs), polychlorinated biphenyls) and emerging contaminants (e.g., 1,2,3-trichloropr...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality. Despite the best available treatments, prognosis remains poor for many HF patients und...
Cell cycle dependent mechanisms triggering lumen formation in vivo
SUMMARY STATEMENT: In humans and other vertebrates, motile cilia located in an organ of asymmetry play an important role in cardiac left-right development. Evidence from model org...
Improving CAR T cell therapy for brain tumors using immune competent models
PROJECT SUMMARY/ABSTRACT The overall objective of this study is to engineer a potent CAR T cell therapy for high grade glioma (HGG), a subgroup of brain tumors for which outcomes...
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome
There is increasing recognition of mitochondria as signaling organelles. An important facet of this “adjunct” mitochondrial function is epigenetic modulation, as exemplified by th...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in euk...
Methods for sequencing data analysis and archive-scale data science
PROJECT SUMMARY We will develop methods and maintain software that make it radically easier for biomedical researchers to use and understand sequencing data. The project will sup...
Molecular Mechanisms of HFpEF-associated Atrial Fibrillation
PROJECT SUMMARY It is said that heart failure with preserved ejection fraction (HFpEF) is the single greatest unmet need in cardiovascular medicine. Patients with HFpEF are uniq...
Leveraging Health System Telehealth and Informatics Infrastructure to Create a Continuum of Services for COVID-19 Screening, Testing, and Treatment: A Learning Health System Approach
PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic reached the US with little warning, and thus caught both public health and medical care delivery systems inadequately prepared to c...
NON-NUCLEASE BASED GENE EDITING FOR HUTCHINSON-GILFORD PROGERIA
Project Summary There is substantial interest in gene editing as a means to treat human genetic disorders such as Hutchinson- Gilford Progeria Syndrome (HGPS). Much effort has be...
Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle Relaxation
Project Summary/ Abstract Light-mediated relaxation of smooth muscle has been recently demonstrated. Non-visual opsins expressed on smooth muscle have been implicated as the key...
Combined Biomaterial and Neuromodulatory Approach to Promote Axonal Outgrowth and Connections After Cervical SCI
Spinal cord injury (SCI) interrupts connections between the motor cortex (MCX) and spinal motor circuits. We propose a novel approach to treat paralysis and weakness after spinal...
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
PROJECT SUMMARY The goal of this study is to examine the functions of the zinc finger protein ZPR1 in R-loops metabolism and neurodegeneration. R-loops are formed during transcri...
Exhaled small RNA biomarkers to detect and monitor airway disease
ABSTRACT “Exhaled small RNA biomarkers to detect and monitor airway disease” Asthma and chronic obstructive pulmonary disease (COPD) together affect over 600 million people world...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk fact...
Direct chemical control of the hematopoietic master transcription factor PU.1
PROJECT SUMMARY/ABSTRACT: Direct control of the hematopoietic master transcription factor PU.1 Hematopoiesis, the process by which all lineages of blood cells are derived, is unde...
Fluid shear stress mechanotransduction at endothelial cell-cell junctions
Project Summary This project aims to understand in molecular detail how fluid shear stress acting on endothelial cells triggers mechanical activation of signaling pathways at cel...