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201,169 grants found
Showing 200,941 – 200,960 of 201,169 grants
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY. Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide. Although anti-VEG...
Development and application of new tools to identify repeat expansions in human diseases
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), causes more than 30 rare but devastating diseases. Despite their importance to monogenic disease, the f...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively in...
Targeting pathologic spike-ripples to isolate and disrupt epileptic dynamics
Project Summary Epilepsy is the world’s most common, serious brain disorder, affecting nearly 50 million people worldwide. For one-third of patients, seizures remain poorly contr...
Mechanisms regulating neural stem cell maintenance in the dentate gyrus
Project Summary Dr. Bond’s primary career goal is to run her own independent academic research group broadly investigating how principles of brain development can be used to unde...
Dissecting Neural Circuits Involved in Musculoskeletal Pain
There is an unmet need to identify therapeutic approaches to alleviate pain associated with inflammatory and osteoarthritic (OA) joint conditions. Joint pain affects over 50 milli...
Managing Cardiac Toxicities of Cancer Therapy
Project Summary This R35 application proposes to capitalize on previous work produced by the PI over the past 11 years and to further serve as a strong foundation for interrogati...
Rapid Understanding of Best Practices in Rural Intensive Care (RUBRIC)
PROJECT SUMMARY/ABSTRACT Background: Nearly 15% of Americans live in rural communities, but only 1% of intensive care unit (ICU) beds are located in those same communities. The C...
Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI
PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term caree...
Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application
Abstract The lung is a natural tolerogenic organ. Lung mucosal tolerance must be exquisitely controlled by the lung immune system to avoid the development of chronic inflammatory...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide. SCC prognosis is context-dependent and does not seem to be determined by driver gene som...
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage
Abstract Subarachnoid hemorrhage (SAH) accounts for 5% of all strokes, has a high mortality and the cost to society is similar to ischemic stroke since subjects are much younger....
Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in TBI
The purpose of this study is to determine whether Acute Intermittent Hypoxia (AIH) is safe to administer to medically stable chronic traumatic brain injury (TBI) patients. There i...
Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC
ABSTRACT National guidelines recommend that women at increased risk for Hereditary Breast and Ovarian Cancer (HBOC) due to BRCA1/2 mutations be referred for genetic counseling an...
Community Paramedicine Program to Improve Diabetes Management among Adults Experiencing Severe Hypoglycemia
PROJECT SUMMARY/ABSTRACT Severe hypoglycemia in the management of diabetes is associated with high morbidity, mortality, psychological distress, and impaired quality of life (QoL...
ROS Targeted Therapy for Lethal Prostate Cancer
PROJECT SUMMARY Prostate cancer (PC) is the second leading cause of cancer mortality in American men. Current therapeutics only show marginal efficacy and are often associated wi...
Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activation
ABSTRACT Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated lung pressures, right heart failure, and premature death. Current therapie...
A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
PROJECT SUMMARY Women at elevated risk for breast cancer should complete genetic counseling and may require more frequent screening or additional tests (e.g. breast magnetic reso...
Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells
Project Summary The goal of this project is to develop new technology to detect circulating tumor cells (CTCs) directly in the bloodstream without having to draw blood samples. M...