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201,169 grants found
Showing 200,861 – 200,880 of 201,169 grants
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control...
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-...
REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students
REACH is an 8-week pipeline summer course for minorities and underrepresented college and high school students interested in careers in neuroscience. Developed, together with Drs....
Characterization of Alternative Polyadenylation in Alzheimer's Disease
Abstract Alzheimer's disease (AD) is a slowly progressive brain disorder characterized by cognitive decline, irreversible memory loss, disorientation, and language impairment. Re...
Investigation of the molecular mechanisms of vascular endothelial dysfunction in Hutchinson-Gilford Progeria Syndrome through in vitro 2D and 3D models
Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare, genetic disorder with features of accelerated aging. The majority of HGPS cases caused by a de novo point mutation...
Probing cytosolic nucleic acid sensing pathways in cancer
ABSTRACT The ability of mammalian cells to elicit inflammation is central to many processes including embryogenesis, wound healing, tissue regeneration, and cancer metastasis. A...
Evaluating and Enhancing Health Information Technology for COVID-19 Response Workflow in a Specialized COVID-19 in a Medically Underserved Community
Project Summary/Abstract The COVID-19 pandemic has exposed vulnerabilities across the United States healthcare system and provided a serious test of hospitals’ resilience. The sy...
Biochemical, structural and molecular dissection of androgen receptor transcriptional activity
PROJECT SUMMARY AND ABSTRACT The androgen receptor (AR) is the master transcription factor responsible for development and maintenance of the male sex phenotype. Aberrant AR acti...
Analysis of conserved eukaryotic transcription elongation factors
PROJECT SUMMARY/ABSTRACT The long-term objectives of this project are to increase our understanding of eukaryotic transcription elongation, with a focus on histone chaperones. Hi...
HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES
ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his clin...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S. Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS “Tobacco Heating System” (IQOS), manufactured by Phi...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process ge...
Sensorimotor learning through adjustments of cortical dynamics
Abstract Extensive research spanning theory, psychophysics, and physiology has investigated how we rely on statistical regularities in the environment to improve our sensorimotor...
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease
Project Summary Silent cerebral infarction is a serious consequence of sickle cell disease (SCD), affecting ~40% of patients by age 15. Although these injuries accumulate occultl...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new appro...
DNA Topoisomerase Misfunctioning in Neurological Disease
DNA topoisomerase II (Top2) carries out changes in DNA structure needed for efficient transcription, replication, and DNA repair. This enzymes introduce transient double strand br...
Bcl-2 as a target in cancer
Project Summary Bcl-2, an anti-cell death protein, is overexpressed in about 40% of all human cancers and contributes to the development and progression of cancer. Overexpression...
The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivo
PROJECT SUMMARY/ABSTRACT Pancreatic β-cells within the islets of Langerhans are required for glucose-stimulated insulin secretion and glucose homeostasis. Dysfunctional β-cell a...
The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension. More than 17 million Americans consume >20% of their calories as fructose and...