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201,169 grants found
Showing 200,841 – 200,860 of 201,169 grants
Core B: Glyco-genomics and Bioinformatics
Core B - Project Summary/Abstract This Program Project will investigate the mechanisms by which glycosylation and glycans may alter the function, maintenance, differentiation, an...
ERβ repurposes EZH2 to suppress oncogenic NFκB signaling in TNBC
PROJECT SUMMARY/ABSTRACT Breast cancer remains the most commonly diagnosed cancer in women and is the second leading cause of cancer-related deaths among women. Triple Negative B...
Core C: GAGomics and Proteomics
Core C – Project Summary/Abstract Glycosaminoglycans (GAGs) are linear O-linked polysaccharides that modify serine residues for a select number of membrane proteins (e.g., glypic...
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment Unhealthy diet is strongly linked to risks of chronic diseases, such as cardiovascular diseases,...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully kn...
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan
This proposal examines how a novel TLR glial signaling pathway drives phagocytic competence in glia, and defines its function in pruning neuronal number and connectivity across li...
Targeting the gut-brain axis to facilitate weight loss in high fat diet consumers
Current therapies for obesity treatment are effective at producing weight loss but weight loss maintenance remains a significant challenge (Franz et al., 2007; Sawamoto et al., 201...
Effectiveness of an Empirically Supported Family Intervention: Mental Health Outcomes, Mechanisms of Effect, and Organizational Factors
Project Summary/Abstract Cost-effective, brief programs to support family communication and improve mental health in youth are a pressing need; yet few evidence-based programs ex...
PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping
Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally. However, a vital step for EHR-based research is valid, accurate, and reliable...
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representations
Although neuroscience has recently provided a great deal of information about how neurons represent and encode behaviorally relevant information at the population level, the funda...
Neighborhoods, Sexual Orientation, Race/Ethnicity & Smoking Across the Adult Lifespan: A Multilevel Intersectional Assessment
Abstract/Project Summary Recent estimates indicate that 11.3 million adults in the United States identify as sexual and/or gender minorities (SGMs) and of these 2.3 million are...
Deciphering principles of network dynamics underlying depression symptom severity from multi-day intracranial recordings in patients with major depression
PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there rem...
Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill children
Project Abstract Overtreatment – health care in which the benefit does not outweigh risks – accounts for up to $200 billion annually in the United States, and is associated with...
Model Based Deep Learning Framework for Ultra-High Resolution Multi-Contrast MRI
Sensitive imaging biomarkers are urgently needed for screening of high‐risk subjects, determine early disease progression, and assess response to therapies in neurodegenerative di...
Exploring neural crest stem cell-derived enteric neurogenesis in post-embryonic development and regeneration
PROJECT SUMMARY/ABSTRACT I am a gastroenterologist at UCLA, and I am committed to studying enteric neurogenesis to better inform development of therapies for enteric neuropathie...
Genetic Biomarkers for Risk of CLL Progression among high-count MBLs
Monoclonal B-cell lymphocytosis (MBL) is a precursor state to chronic lymphocytic leukemia (CLL), and one of the most common premalignant conditions. MBL is present in 5-10% of th...
Experimental and computational analysis of mechanisms of mitochondrial-cellular ROS crosstalk in the kidney in salt-sensitive hypertension
PROJECT SUMMARY Salt-sensitive hypertension is a significant health problem worldwide and there is a need to understand the underlying molecular mechanisms to enable more effecti...
Vascular calcification and atherosclerosis
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in the U.S., with the annual total cost of care estimated at $351 billion. Vascular calcificat...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computati...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract A recent critical analysis of biologically active molecules and reactions most often used for their preparation suggests that fraction of saturated carb...