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201,169 grants found
Showing 200,821 – 200,840 of 201,169 grants
Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making
Project Summary/Abstract Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making The accumulation of evidence over time is a critical aspect of many types of...
Inside-out construction of the biliary system
Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver. Congenital or acquired abnormalities in the formation and p...
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?
High IOP is a major causal risk factor for glaucoma and is the target of all current glaucoma therapies. This project investigates pathways that control intraocular pressure. Abno...
Defining the genetic landscape of nanophthalmos and the role of MYRF
Defining the genetic landscape of nanophthalmos and the role of MYRF ABSTRACT: Nanophthalmos is part of a spectrum of disorders characterized by a small eye and resultant high hy...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated varian...
A First-in-Class FAP-activated Protoxin to disrupt the Tumor-Stroma Parasitic Cycle fueling lethal Prostate Cancer Progression
Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC). Additionally, the propo...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Understanding and leveraging molecular diversity within the phytochrome superfamily. Our proposal focuses on the phytochrome superfamily of photoreceptors. We have a longstanding...
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration. Many studies have demonstrate...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as de...
Second Generation Gene Therapy for APOE4 Homozygous Individuals at High Risk for Alzheimer's Disease
Alzheimer’s disease (AD), a degenerative brain disease and the most common cause of dementia, currently affects 5.8 million Americans and 50 million people worldwide. AD symptoms i...
Using nicotine to reverse age-related auditory processing deficits
Age-related decline in central auditory function significantly affects quality of life in the elderly, with impaired speech perception leading to increased risk for depression, soc...
Investigating Mechanisms of Hyperprogression on Anti-PD-1 Immunotherapy
Abstract The number of cancer patients being treated with checkpoint blockade immunotherapy (CBI) targeting the PD- 1/PD-L1 pathway is increasing dramatically. Recently a novel a...
Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases
An important question in the field of multiple sclerosis (MS) is whether myelin/axonal damage in the white matter facilitates neuronal cell body loss in the gray matter, or result...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional sele...
Synaptic mechanisms of auditory thalamic cross-modal communication
ABSTRACT Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and changing cognitive demands. Failure to quickly shift perceptual resources...
WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common kidney cancer in children. High-risk patient groups continue to have dismal outcomes. The greatest predictor of a poor out...
Assessment of EEG Responses to Spinal Cord Stimulation Waveforms in Chronic Pain Patients
Chronic pain is a significant problem and it has been estimated to affect about 50 million adult Americans. It accounts for more than 600 billion dollars in health care expenditure...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes. The tumor suppressor protein p53 is a transcription factor orchestra...
Molecular and Clinical Glycobiology of the Bone Marrow Environment
The life-long production of blood cells requires hematopoietic developmental programs guided by systemic and local signals to convey the dynamic need for these cells. How these si...
Core A: Administrative Core
Administrative Core - Project Summary/Abstract The Administrative Core is located within the administrative offices of the Blood Research Institute (BRI), the research arm of Ver...