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201,169 grants found
Showing 200,801 – 200,820 of 201,169 grants
Methods for Mendelian randomization and mediation analysis using integrative genetic and genomic data for breast cancer
Project summary Haoyu Zhang, PhD is a statistician whose ultimate career goal is incorporating advanced causal inference techniques into genetics and biological research in order...
Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)
PROJECT SUMMARY Environmental contamination by per- and polyfluoroalkyl substances (PFASs) is a major public health concern because of the wide range of toxic effects that have b...
Activity-Dependent Tagging of Cerebellar Neurons for Studying Signal Processing and Learning
PROJECT SUMMARY The goal of the proposed research is to implement state-of-the-art techniques for recording and manipulating neurons based on their activity in the cerebellum, to...
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for mol...
Developmental origins and early detection of ADHD and dysregulatory psychopathology
PROJECT SUMMARY: The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral and emotional problems. To do so children are follow...
The role and regulation of p53 in obesity-induced liver cancer
Project Summary/Abstract Obesity is a prevalent global health problem, and it increases the overall risks of many types of chronic diseases and cancers. Nonalcoholic steatohepati...
Mitigating sexual stigma within healthcare interactions to improve engagement of MSM in HIV prevention
Long-term objective. My long-term objective is to explore, identify and evaluate acceptable, feasible and appropriate techniques and mechanisms to mitigate HIV-related stigma in h...
Interplay Between Nuclear Organization and Function
PROJECT SUMMARY/ABSTRACT Goals: Peri-Centromeric Heterochromatin (PCH) is required for genome stability/DNA repair, chromosome pairing, nuclear architecture, and transposon and...
Identifying the sequences and factors that govern the fate of elongating RNAPII
PROJECT SUMMARY: Precise control of gene expression during development and in response to signals is essential for organismal growth and homeostasis. Accordingly, gene expression...
SARM1 functional polymorphisms and their contribution to ALS risk
Motor axon loss is a cardinal symptom of amyotrophic lateral sclerosis (ALS). Axon loss can be driven by a genetically encoded program in which the axon survival factors NMNAT2 an...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense ag...
Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy
Our overarching hypothesis is that senescent stromal fibroblasts, especially if they elicit an inflammatory response, promote progression to lethal disease in men with prostate ca...
Defining the function and mechanism of regulatory ribosomal ubiquitylation
PROJECT SUMMARY Protein homeostasis (proteostasis) relies on the continual surveillance and removal of defective translation products resulting from the relatively high error rat...
Neural mechanisms of active vision in the fovea
Neural mechanisms of active vision in the fovea In many ways human vision is like a camera, with a lens that forms an image on a spatially arranged sensor (the retina). However,...
Senescent Vascular Cells as Mediators of Cognitive Decline
PROJECT SUMMARY The goals of this proposal are to (1) obtain experimental skills and career training necessary to develop an independent research program investigating mechanisms...
Traditional healer-initiated HIV counseling and testing in rural South Africa
Project Summary In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to t...
Mapping the short-range chromatin architecture of the repressive epigenome
Project Summary Genome architecture is associated with many essential cellular processes from transcriptional regulation to chromosome segregation. Recent technological innovatio...
Elucidating the molecular mechanisms underlying ligand-dependent REV-ERB activity in Th17 cells
Project Summary/Abstract Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis are characterized by an inappropriate immune response to commensal gu...
Dissecting the role of neural inputs in the regulation of AgRP neurons
Project Abstract: Proper regulation of food intake is essential for survival to prevent over- or under-feeding. Sensory signals generated by the detection and consumption of food...