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201,169 grants found
Showing 200,781 – 200,800 of 201,169 grants
Identifying gene regulatory networks controlling photoreceptor specification by transcriptomic and epigenomic analysis of retinal development in cone-dominant retina
Project Summary While degeneration of cone photoreceptors is the ultimate cause of blindness in photoreceptor dystrophies, mouse and human retinas are rod photoreceptor-dominant,...
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS
PROJECT ABSTRACT The goal of the proposed project is to provide Ms. Brianna Kiefer with training opportunities at Purdue and Columbia University from Drs. Jessica Huber, Michelle...
Targeting Atg5 in platinum-resistant ovarian cancer
Abstract Ovarian cancer is the fifth leading cause of cancer-related death in the United States. The standard first line chemotherapy to treat this deadly disease includes platin...
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury
Sepsis accounts for nearly 50% of acute kidney injury (AKI) in the intensive care unit and significantly impacts mortality. However, therapy for sepsis-associated AKI (SA-AKI) has...
Dissecting and reconstructing the molecular roadmaps of cellular reprogramming to iPSCs in single-cell resolution
Project Summary Understanding the molecular programs that guide cell fate conversion will provide a foundation for the development of tools to convert cell fate and eventually fa...
Molecular Mechanisms of Arrestin-Domain Containing Proteins in Metabolism
The arrestin superfamily is composed of two subfamilies: the classical visual/beta-arrestins that were first identified as regulators of G-protein coupled receptor signaling, and t...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc...
Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies
Molecularly targeted cancer therapies, such as Abl-targeted tyrosine kinase inhibitors (TKIs), have converting many terminal cancers, including chronic myeloid leukemia (CML), int...
Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers
Abstract Extracellular vesicles (EVs) are membranous particles released from nearly all cell types into all bodily fluids evaluated to date — including serum and plasma. Dependin...
Establishing the Limits of Perceptual Inference for Visual Motion
Learned statistics about the world play an important role in dictating our sensory perception. When incoming sensory inputs carry limited information, such as in low-contrast cond...
Understanding the intestinal regenerative response using patterned organoids in photo-tunable PEG hydrogels
Project Summary Nonspecific targeting of highly proliferative, non-cancerous cell types during chemotherapy highlights the limitations of these treatment modalities. In the intes...
Roles of glycinergic neurons in Dravet syndrome-associated disordered breathing and mortality
Summary Dravet syndrome (DS) is a severe form of epilepsy with a high rate of SUPEP. Respiratory failure is a leading cause of SUDEP, and DS patients' frequently exhibit disorder...
Inhibitory Network Dynamics Supporting Hippocampal Spatial Representations
Project Abstract The hippocampus is a mammalian brain structure critical for various cognitive functions, including spatial navigation and episodic memory. Hippocampal area CA1,...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tu...
Molecular mechanisms and functions of global chromatin control
Project Summary/Abstract The long term goal of the proposed study is to determine, at the molecular level, mechanisms and functions of chromatin regulation at a global level. Chr...
Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells
PROJECT SUMMARY/ABSTRACT PI: Snow, Andrew L. The healthy immune system depends upon a balance of proliferation and death of white blood cells, including B and T lymphocytes, to...
Hematopoietic Stem Cell Transplantation Combined with CSF1 Inhibition to Attenuate the Pathogenesis of Alzheimer's Disease
PROJECT SUMMARY Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by misfolded, aggregated proteins (in particular, amyloid beta and tau) and chronic activat...
Examining the effects of retinal cell loss on downstream visual brain areas
Because humans rely heavily on vision to experience the world, diseases of the eye are particularly debilitating in that they have significant adverse effects on patient health an...
The impact of G-quadruplexes on genome evolution
PROJECT SUMMARY Apart from the double-helix B-DNA structure discovered by Watson and Crick, approximately 13% of the human genome comprises sequence motifs that can form non-cano...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learni...