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201,169 grants found
Showing 200,761 – 200,780 of 201,169 grants
cryoEM Administrative Supplement for Equipment
ABSTRACT Funds are requested for the purchase of a revolutionary new camera, the Apollo, from Direct Electron Ltd. that would enable the collection of large amounts of image data,...
Motherhood Biographies and Midlife Women's Health
Abstract The Motherhood Biographies and Midlife Women?s Health R01 project maps how divergence in motherhood experiences contributes to growing midlife health disparities. About 85...
AAV-Mediated Gene Therapy for CNS Disease Correction in Feline NPC1 Disease
Project Summary/Abstract Niemann-Pick disease type C1 (NPC1 disease) is a hereditary disorder characterized by the lysosomal storage of cholesterol and sphingolipids, and clinical...
Random Field Modelling of genetic and epigenetic association underlying congenital heart defects in the presence of disease heterogeneity
Project Summary/Abstract This proposal is submitted for an extension of the NHLBI K01 award, entitled ?Random field modeling of genetic and epigenetic associations for congenital h...
Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction
PROJECT SUMMARY This proposal is a new application entitled "Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction". The questio...
Iowa StARR Scholars Program
PROJECT SUMMARY The Iowa StARR Scholars Program is designed to help address the continuing need for physician-scientists in the fields of internal medicine and pediatrics. The Un...
Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors and lung cancer prognosis
Project Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic drugs. The use of this class of drugs is on the rise. In addition t...
Mechanism and dynamics of islet GABA signaling
Gamma-aminobutyric acid (GABA) is a potent neurotransmitter produced in the islet at levels as high as in the brain. While the function of GABA in the nervous system is well-unders...
High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
Project Summary Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subs...
Predicting and Preventing Ventilator-Induced Lung Injury
Project Summary Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure that is caused by factors ranging from pneumonia to sepsis. The impact of ARDS is...
The regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1
Summary: Acute kidney injury (AKI) is a major renal disease that can be caused by ischemia, sepsis, urinary obstruction and nephrotoxins. It is associated with high mortality cli...
Elucidation of a Eukaryotic Chemorepulsion Mechanism
The directed movement of eukaryotic cells away from a source of a chemorepellent appears to play a major role in development and the resolution of inflammation, but very little is...
A Multi-Site Evaluation of Primary Care Accessibility and Utilization during COVID-19
ABSTRACT The objective of the proposed research is to evaluate how patient access and utilization of primary care was disrupted by COVID-19 across three healthcare systems, with...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguish...
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
PROJECT SUMMARY/ABSTRACT Kidney disorders comprising acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) account for significant morbidity...
Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human Brain
PROJECT SUMMARY/ABSTRACT Anxiety is a common symptom across psychiatric disorders and is associated with worse quality of life and impairment. However, the existing treatments fo...
Early Respiratory Care in Amyotrophic Lateral Sclerosis Patients at High Risk for Respiratory Failure
Project Summary/Abstract Respiratory failure commonly occurs in amyotrophic lateral sclerosis (ALS) and leads to significant morbidity and mortality. The onset of respiratory wea...
The Conformational Dynamics of eIF5B During Ribosomal Subunit Joining
ABSTRACT Translation initiation in eukaryotes, which requires over a dozen eukaryotic initiation factors (eIFs), is a highly regulated process that helps establish the fidelity...
Remotely controlled listerial bactodrones for cancer immunotherapy
PROJECT SUMMARY Attenuated and avirulent strains of Listeria monocytogenes (Lm), that are delivered via intravenous injections, accumulate and propagate in primary tumors and met...
Mitigating risk from macroeconomic stress on child mental health: Exploring protective effects of universal preventive intervention
The broad goals of this study are to strengthen our understanding of how social determinants of health, specifically socioeconomic conditions and associated stressors, can be miti...