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201,169 grants found
Showing 200,741 – 200,760 of 201,169 grants
Brain Pericytes and the Progression of Alzheimer's Disease
To sustain the health of tissues in the body, the circulatory system needs to efficiently and continuously supply O2 and nutrients to every living cell in the brain, while also rem...
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
The 2013?2016 Ebola virus (EBOV) disease epidemic was orders of magnitude larger than any previous EBOV outbreak. Preliminary data indicate that GP-A82V, an EBOV glycoprotein mutan...
Targeted activation of autoimmune checkpoints in B cell malignancies
Targeted therapy of cancer typically focuses on agents that suppress oncogenic signaling below a minimum threshold needed for survival and proliferation. Here, we propose a novel s...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molec...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in t...
ILC2s Polarize Microglia to a Reparative, M2-Like Phenotype
Project Summary: Stroke is the fifth leading cause of death in the United States, predominantly affecting aged people. FDA approved treatments are proving inadequate as many patie...
Cortical circuit mechanisms of visual shape processing
PROJECT SUMMARY Humans and other primates rely on using visual shape information to identify and interact with objects in the world. The goal of this project is to gain mechanist...
Identifying primary targets of bumped kinase inhibitor derived compounds to improve utility as therapy for castration resistant prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer (CRPC) that inevitably escapes primary therapies most often retains dependency on androgen receptor (AR). We are rep...
Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making
Project Summary/Abstract Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making The accumulation of evidence over time is a critical aspect of many types of de...
Supraspinal Control of Human Locomotor Adaptation
Title Supraspinal Control of Human Locomotor Adaptation Abstract Advances in electroencephalography (EEG) technology have made it feasible to study electrical brain dynamics during...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
The Role of the Metaplastic Microenvironment in Barrett's Esophagus
Project Summary Esophageal Cancer is a leading cause of cancer death worldwide. The two subtypes include Esophageal Squamous Cell Carcinoma (ESCC) and Esophageal Adenocarcinoma (EA...
Exploring cyclic di-nucleotide signaling across the tree of life
Project Summary is not required for this equipment supplement.
A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animals
PROJECT SUMMARY The aim of this proposal is to deliver an innovative and easy-to-use experimental platform for measuring and quantifying naturalistic behaviors of mammalian anima...
UNDERSTANDING AND LEVERAGING MOLECULAR DIVERSITY WITHIN THE PHYTOCHROME SUPERFAMILY
April 1, 2021 Our proposal focuses on the phytochrome superfamily of photoreceptors. We have a longstanding interest in these proteins and in the linear tetrapyrrole (bilin) chromo...
Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation
Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation Administrative Supplement NOT-GM-21-030 R01GM140129 Summary. Broadly...
Childcare Supplement request
Myocardial infarction causes irreversible loss of cardiomyocytes (CMs) and often leads to heart failure. To replace the lost cells, we identified a combination of cell-cycle regula...
Administrative Equipment Supplement to Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors
Abstract for R01GM140560: Sialylated glycans are involved in complex regulation and signaling, and play a critical role in disease. In the virus life cycle receptor binding and sia...
Enabling Mass Spectrometry Analysis of the Sulfoproteome Supplement
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
Novel Nutrient Functions and Sensing Mechanisms
Project Summary/Abstract Despite its long history, the nutrient biology field is still facing a plethora of outstanding questions closely related to human health, two of which w...