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201,169 grants found
Showing 200,721 – 200,740 of 201,169 grants
In vivo Drug Testing of Pediatric CNS Tumors Using Patient Derived Orthotopic Xenograft Models
PROJECT SUMMARY/ABSTRACT This application is prepared for an extension of our previously funded research proposal that was in response to RFA-CA-14-018, Pediatric Preclinical Testi...
Neurocognitive Consequences of Intermittent Hypoxia
Abstract Sleep apnea is a respiratory disorder that causes intermittent hypoxia (IH) and is known to negatively impact learning and memory. Neurobiological processes within the hip...
How does disrupting parvalbumin interneuron-generated gamma oscillations affect the encoding of rule shifts in the prefrontal cortex?
PROJECT SUMMARY (PARENT GRANT) Rhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many cases these oscillations are synchr...
Cellular and molecular control of tooth morphogenesis
ABSTRACT Tooth bioengineering is of great interest, because dental decay and tooth loss constitute an important public health issue. Additionally, tooth anomalies are common in man...
Large-scale recording of spike train ensembles from muscle fibers during skilled behavior in mice and songbirds
A crucial problem in neuroscience is to understand how the brain coordinates muscle activity to produce behavior. For decades, researchers have approached this problem by recording...
Diversity Supplement to 2R01NS064004
Hyperreflexia is a devastating consequence of a lesion that damages the corticospinal tract (CST), in isolation, or at its origins in the cortex, or after a spinal cord injury (SCI...
Precision Medicine Approach: Using genomic information to guide TBI treatment
ABSTRACT Concussive injury or mild/moderate TBI (mTBI) accounts for a large majority of the brain injuries in USA and compromises neuronal function and cognitive abilities. The mai...
Effects of TrkB Activation on Abnormalities in Neocortical FS interneuron
Project Summary Abnormalities in parvalbumin (PV) and somatostatin (SOM) interneurons are reported in a number of neurological disorders, including epilepsy. Therapy that improves...
Disparities in the Use of Oral Anticancer Agents in Kidney Cancer
We have long known that real-world black-white racial disparities have existed in the treatment and outcomes of patients with renal cell carcinoma (RCC). However, it is unclear how...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)?the only randomized controlled trial (RCT) comparing foster care to institutional care for young children?w...
Glycosylation Analysis by Sheath-Flow SERS
Project Abstract Protein glycosylation plays important roles in various human diseases, including cancer, inflammatory, and neurodegenerative diseases. Glycoproteins, therefore,...
Impact of alcohol exposure on unjamming the airway epithelium
PROJECT ABSTRACT Alcohol use disorder affects over 14 million adults and causes 88,000 deaths each year in the United States. Chronic alcohol use significantly increases people’s...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolu...
Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
Abstract In the United States, colon cancer and rectal cancer are the third most common cancer diagnosed in both men and women. The standard of care for stage II-III rectal canc...
The Role of Inflammation in Post-stroke Epileptogenesis
PROJECT SUMMARY/ABSTRACT OF PARENT GRANT Epilepsy is a common consequence of brain insults, such as brain injuries, status epilepticus, and cerebrocortical stroke in the elderly an...
Mechanisms modulating cell identity in regenerative mammalian epithelia
PROJECT SUMMARY: Significance: Our tissues experience frequent damage from injuries, infections and disease. Many organs in the human body can undergo self-repair to restore their...
Regulation of Skeletal Growth by Soft Tissue Extracellular Matrix
PROJECT SUMMARY Mutations in several secreted ECM proteins, including ADAMTSL2, ADAMTS10, ADAMTS17, LTBP2, LTBP3, and fibrillin-1 (FBN1), can cause acromelic dysplasias, such as ge...
Function of Kdm4dl-mediated heterochromatin removal in the preimplantation mouse embryo
PROJECT ABSTRACT This project will investigate the function of a currently unstudied histone demethylase, Kdm4dl, in the mouse preimplantation embryo. Many others have shown the...
Developing computational algorithms for histopathological image analysis
Project Summary Histopathology is the cornerstone of disease diagnosis and prognosis. With the advance of imaging technology, whole-slide image (WSI) scanning of tissue slides i...
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.
Parkinson’s Disease (PD) is a common neurodegenerative disorder affecting human movements. PD is not just a motor disease. It also results in impaired multi-sensory processing tha...