Browse All Grants
201,169 grants found
Showing 200,701 – 200,720 of 201,169 grants
AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids
This work is directed at characterizing pediatric COVID-19 and stratifying incoming patients by projected (future) disease severity. Such stratification has several implications: i...
Diagnosis of MIS-C in febrile children
PROJECT SUMMARY The recent emergence of SARS-CoV-2 and resultant pandemic of COVID-19 disease has overwhelmed global health systems and led to over 200,000 American deaths to date....
Severity Predictors Integrating salivary Transcriptomics and proteomics with Multi neural network Intelligence in SARS-CoV2 infection in Children (SPITS MISC)
Abstract Children have been disproportionately less impacted by the Corona Virus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SAR-CoV-2)...
The Role of Altered Luminal Dynamics in OSA-Induced Atherosclerosis
ABSTRACT The prevalence of obstructive sleep apnea (OSA) has been estimated to be 34% for men and 17% for women between 30 and 70 years old, but is far more common among patients...
Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)
PROJECT SUMMARY / ABSTRACT In adults, SARS-CoV-2 infection exhibits a wide range of clinical outcomes, from asymptomatic and mild disease to severe viral pneumonia, respiratory dis...
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19
ABSTRACT Novel approaches for early and accurate diagnosis of COVID-19 associated syndromes and evaluation of clinical severity and outcomes of COVID-19 disease in children are urg...
COVID-19 Network of Networks Expanding Clinical and Translational approaches to Predict Severe Illness in Children (CONNECT to Predict SIck Children)
The SARS-CoV-2 pandemic has manifested in children with a wide spectrum of clinical presentations ranging from asymptomatic infection to devastating acute respiratory symptoms, app...
Senescent Vascular Cells as Mediators of Cognitive Decline
PROJECT SUMMARY The goals of this proposal are to (1) obtain experimental skills and career training necessary to develop an independent research program investigating mechanisms o...
How alpha-Synuclein misfolding promotes tau pathology in ADRD
Abstract The parent award to this Administrative Supplement for AD and ADRD research studies alpha-Synuclein (aSyn) oligomerization in great biophysical detail, using state-of-the...
Multiscale Models of Wound Cell Plasticity for Regeneration
In regenerative medicine, it is critically important to understand the complex mechanisms that rewrite and stably maintain cellular memory in order to reprogram cells to the new, d...
Novel actions of neurosteroids on GABA (A) receptor trafficking
Project Summary This application is for a diversity supplement to the R01 NS108378, entitled ?Novel actions of neurosteroids on GABAAR trafficking? the PIs of which are Dr. Paul Da...
Methods to Identify, Validate & Interpret GWAS Loci in Multi-ethnic Meta-analysis
ABSTRACT Large scale genetic datasets have revolutionized human genetic research. In the past decade, genome-wide association studies have identified numerous genetic variants ass...
The pursuit of genetic causal mechanisms
Project Summary Recent years have witnessed the development of large research projects that involve genotyping hundreds of thousands of individuals, on which we have available de...
Mechanisms of hippocampal network-targeted stimulation to rescue memory impairment due to Alzheimer's disease
Supplement Project Summary/Abstract The purpose of this administrative supplement for our ongoing grant ?Cellular mechanisms of hippocampal network neuroplasticity generated by bra...
Dissecting the mechanistic role of multinucleation in breast and trophoblast cancers
Project Summary/Abstract A key driver of cancer is the global deregulation of transcription networks in the cell. Transcriptional output is dependent on chromatin structure and to...
20-HETE Formation Inhibitors in Cardiac Arrest
Project Summary Evidence has demonstrated that 20-hydroxyeicosatetraenoic acid (20-HETE) is a key microvascular constrictive regulator and is formed by the omega-oxidation of arach...
Defining the Role of Microglia in the Synaptic Rewiring of the Hypothalamus by Early life Adversity
PROJECT SUMMARY: Early-life adversity can profoundly impact an individual?s risk for stress-related emotional disorders including depression, likely by modulating the maturation of...
Dissecting and reconstructing the molecular roadmaps of cellular reprogramming to iPSCs in single-cell resolution
Project Summary Understanding the molecular programs that guide cell fate conversion will provide a foundation for the development of tools to convert cell fate and eventually faci...
Brain Single-nuclei and iPS-derived cells transcriptomic analysis to define the contribution of neuronal and glial pathw
Abstract Alzheimer?s disease (AD) is a complex and heterogenous condition in which multiple molecular pathways are disrupted in different cell-types and lead to disease. Genetic fi...
Inhibition of Candida Virulence and Biofilm Formation by a Bacterial Peptide
PROJECT SUMMARY The medical condition oropharyngeal candidiasis (OPC) is a major source of oral morbidity in patient groups including the immunosuppressed (cancer and AIDS patients...