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201,169 grants found
Showing 200,641 – 200,660 of 201,169 grants
Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)
PROJECT SUMMARY Environmental contamination by per- and polyfluoroalkyl substances (PFASs) is a major public health concern because of the wide range of toxic effects that have bee...
COVID-19: Elucidating the Role of the NasalEpithelium in SARS-CoV-2 Infection, Transmission, and Prevention
ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximate...
Hippocampal-prefrontal mechanisms of learning to learn
Project summary The mammalian brain is remarkably ecient at rapidly learning from experience. We can quickly form generalizations about our environment based on previously acquired...
Development of Glypican-2 redirected T cells for the Treatment of Neuroblastoma
Project Summary The objective of this proposal is to develop a T cell-based immunotherapy for the treatment of high-risk neuroblastoma (NB), for which outcomes remain poor. The ado...
The Role of Medial Prefrontal Cortex in the Memory for Sequences of Events
PROJECT SUMMARY/ABSTRACT Temporal organization is critical to many perceptual, cognitive, and behavioral functions. These temporal abilities are adversely impacted in several menta...
Modeling myelodysplasia
PROJECT SUMMARY Myelodysplastic Syndromes (MDS) are a cancer of the hematopoietic stem cell (HSC) on the rise in the aging population and cancer survivors. The only curative treatm...
Understanding rhythmic gene regulatory mechanisms in the mammalian circadian system
Summary Circadian rhythms are biological, physiological, and behavioral processes that enable organisms to respond to the environmental changes caused by the rotation of the Earth...
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deterio...
Modeling Immune Cell Recruitment and its Impact on Triple Negative Breast Cancer Recurrence in the Irradiated Microenvironment
PROJECT SUMMARY Approximately half of triple negative breast cancer (TNBC) patients receive breast conserving therapy, which includes irradiating the primary tumor site. Although t...
Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)
Project Summary The recalcitrant and harmful chemicals such as PFASs (per- and polyfluoroalkyl substances), endangers the environmental, wild-life, and human health profoundly. Amo...
Non-genetic optical stimulation platform for the next-generation neuroscience drug discovery assays
ABSTRACT Despite tremendous advances in fundamental neuroscience research, the success rate of neuroscience drug discovery has been disappointingly low. Among potential factors co...
Memory-promoting Ad vaccine for long-lived protection against SARS-CoV-2
This grant will establish immunologic proof-of-concept for a second-generation SARS-CoV-2 vaccine providing extraordinarily durable T-cell and antibody responses, which together pr...
Mentoring and research to prepare oral PrEP delivery platforms for novel HIV prevention products
ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured approac...
A sequential, adaptive model of differentiated service delivery to reach persons living with HIV who are lost-to-follow-up or who have detectable viral load
ABSTRACT Globally, more than half of the world's 37 million people living with HIV are on antiretroviral therapy (ART) representing immense and encouraging success with access to H...
Traditional healer-initiated HIV counseling and testing in rural South Africa
Project Summary In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the...
Mitigating sexual stigma within healthcare interactions to improve engagement of MSM in HIV prevention
Long-term objective. My long-term objective is to explore, identify and evaluate acceptable, feasible and appropriate techniques and mechanisms to mitigate HIV-related stigma in he...
How does covert attention modulate visual perception? Psychophysics, neurostimulation and neuroimaging
Project Summary Covert spatial attention is a selective process that filters incoming information. Given the high cost of cortical computation, such a mechanism is needed for optim...
The design and evaluation of strategies to implement HIV prevention interventions for pregnant women in community pharmacy settings
PROJECT SUMMARY: Pregnant women in high HIV-burden settings such as western Kenya are at increased risk of acquiring HIV infection during pregnancy. The World Health Organization (...
SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population
This proposal seeks to address a key challenge in public health : the ongoing and fine-grained measurement of population mental health. Currently, in the largest population surveys...
Achieving Outstanding Cardiovascular Health Outcomes for All Ohioans: a Statewide Cardiovascular Health Collaborative (Cardio-OH)
Project Summary Modifiable cardiovascular disease (CVD) risk factors such as hypertension, cholesterol and smoking contribute strongly to CVD morbidity, mortality, and health care...