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201,169 grants found
Showing 200,621 – 200,640 of 201,169 grants
Versatile Eye Tracking for Improved High-resolution Retinal Imaging
Project Summary/Abstract Physical Sciences Inc (PSI) proposes to develop a robust eye tracking technology to enhance the quality of high-resolution retinal imaging videos by signi...
Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
Project summary Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy resulting from demyelination and axon degeneration. Many cases of axon degeneration are caus...
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan
This proposal examines how a novel TLR glial signaling pathway drives phagocytic competence in glia, and defines its function in pruning neuronal number and connectivity across lif...
Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials
Project Summary The project addresses a common challenge in the remediation of groundwater contaminated with chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane. CVOCs...
Neural Mapping of the Social Landscape
PROJECT SUMMARY Psychiatric disorders that feature social impairment (e.g., Autism Spectrum Disorder) pose a significant health burden in the United States. Attempts to understand...
Strategies to target BCR-ABL1 compound mutants in CML and Ph+ ALL
Abstract: Philadelphia chromosome-positive (Ph+) leukemia is caused by BCR-ABL1, a constitutively active fusion kinase. Tyrosine kinase inhibitors (TKIs) targeting the ATP site of...
Control of Colitogenic Th17 cells by Vitamin D Receptor Signaling
PROJECT SUMMARY Vitamin D (Vit D) deficiency is estimated to affect over 1 billion people worldwide and is now considered a global health crisis. In addition to maintaining calcium...
Proteomic discovery and characterization of chemical tools that degrade the NuRD chromatin regulatory complex
Project Summary As virtually all aspects of cell behavior and identity converge upon programmed responses in gene expression, transcriptional control features centrally in both nor...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to cirr...
Cellular and molecular mechanisms underlying DDX3X syndrome
Abstract Mutations in DDX3X are strongly associated with autism spectrum disorder (ASD), and may account for 1-3% of unexplained developmental delay (DD) in females, making this o...
Advancing native top-down protein analysis with hybrid SID/ECD technology
The capabilities of native mass spectrometry have improved dramatically in recent years due to advances in instrument speed, resolution, mass accuracy, and ion optics designed spec...
Humanization of ACE2 and Associated Priming Proteases in New Mouse Models for Downstream Disease and Therapy Investigations of COVID-19
With the initial wave of zoonotic transmission firmly established in the human population worldwide, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) poses an e...
Low Cost OCT Angiography with Spectroscopic Contrast
Project Summary The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this object...
A Novel Broad-spectrum Antiviral Agent
Summary Accelerating emergence and re-emergence of a wide array of viral epidemics has been a deadly feature of the 21st century. Potent or even effective therapies are rarely avai...
Tracking the dynamics of how schemas scaffold recall
Project Summary Every new experience in our life takes place within the context of familiar environments and situations. However, most research on memory has focused on the artific...
Characterizing the effects of cis-regulatory variation on patient outcomes and treatment response in Multiple Myeloma
ABSTRACT Multiple Myeloma (MM) is a malignancy of plasma cells and the second most common hematological cancer accounting for 2% of cancer deaths. MM is associated with a poor prog...
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
ABSTRACT - In the post-ischemic heart, relatively little is known about the injured-but-not-infarcted myocardium, which we call the intermediate zone as it is neither normal nor in...
Determing the genetic basis of responses to biomechanical strain in an in vitro model of osteoarthritis
Osteoarthritis (OA), a degenerative joint disorder characterized by articular cartilage damage and alterations to the structure of subchondral bone, is the most common joint diseas...
The 7th Military Vision Symposium on Ocular Readiness for Military Conflicts and Civilian Casualties
Abstract: This application is a request for funding to support of the 7th Military Vision Symposium that is the only meeting of its kind bringing together military and civilian oph...
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healing
In recent years, new technological advancements in small molecule analyses (e.g., lipidomics) have identified a biochemical manifestation of impaired wound healing: the development...