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201,169 grants found
Showing 200,601 – 200,620 of 201,169 grants
In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET
PROJECT ABSTRACT Exposure to repetitive head impacts (RHI) through participation in contact sports can result in symptomatic concussions and asymptomatic sub-concussions and may in...
Lateral habenula circuit dysregulation in mild traumatic brain injury
Summary Traumatic brain injury (TBI) contributes to almost 30% of all injury-related deaths in the United States, but the majority of TBI injuries are mild (mTBI). Anxiety, depress...
Activity-Dependent Tagging of Cerebellar Neurons for Studying Signal Processing and Learning
PROJECT SUMMARY The goal of the proposed research is to implement state-of-the-art techniques for recording and manipulating neurons based on their activity in the cerebellum, to d...
A novel polymer-metal nanocomplex for ovarian cancer treatment
Summary: Ovarian cancer is the leading cause of death from gynecologic malignancy. Most women are diagnosed with metastatic ovarian cancer, and the 5-year survival rate for this la...
Lung Innate COVID-19 Defense Specific to Veterans Risk Characteristics
COVID-19 is now a global pandemic requiring a rapid and concerted response from the scientific and medical community. Based upon recent epidemiology derived only months earlier fro...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immunot...
Targeting the gut-brain axis to facilitate weight loss in high fat diet consumers
Current therapies for obesity treatment are effective at producing weight loss but weight loss maintenance remains a significant challenge (Franz et al., 2007; Sawamoto et al., 201...
COVID-19: Understanding The Role of Corona Virus InducedDisruption Of Alveolar Type 2 Cell Function And SurfactantHomeostasis In The Pathogenesis Of COVID-19 AcuteRespiratory Distress Syndrome
ABSTRACT The Severe Acute Respiratory Syndrome (SARS)-associated coronavirus 2 (SCoV2) is the cause of COVID-19 syndrome which is marked by a refractory acute lung injury that resu...
Hedonic hotspot interactions for the generation of 'liking' and 'wanting'
PROJECT SUMMARY: The primary role of this proposal is to investigate the corticolimbic circuitry that controls `liking' reactions to rewards, such as palatable sweet tastes. `Likin...
SCH: Context-aware Freezing of Gait mitigation in real-world setting
See attached. RELEVANCE (See instructions): See attached.
Oral Immunology/Microbiology research group annual meeting
The Oral Immunology/Microbiology Research Group (OIMRG) was founded as a means of promoting collegial interaction and collaboration among researchers interested in the immunology a...
BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline
ABSTRACT Clinical Need: As the US population ages, managing pathologies that largely affect older adults, including sarcopenia (e.g., loss of muscle mass and strength), represents...
Magnetic Bronchoscope for Improved Pulmonary Access
One of every 16 Americans will be diagnosed with lung cancer in their lifetime. Each year in the United States there are nearly 250,000 new diagnoses and 150,000 deaths with an est...
Thalamolimbic circuit mechanisms for social threat processing
Patients with posttraumatic stress disorder (PTSD) experience debilitating deficits in threat inhibition, resulting in hypervigilance, reexperiencing traumatic events, and severe s...
Identification of novel phosphodiesterase (PDE)-modulating compounds and characterization of associated cytoprotective pathways in lightdamagedretina
PROJECT SUMMARY Cyclic nucleotide phosphodiesterases (PDEs) are a class of enzymes ubiquitously expressed in the human body, and they play a critical role in a broad range of physi...
Modeling mutant PfCRT-mediated drug transport to predict the emergence of piperaquine-resistant Plasmodium falciparum malaria
PROJECT SUMMARY The protozoan parasite Plasmodium falciparum causes over 400,000 malaria deaths each year, mostly in young African children. With no effective vaccine, chemotherapy...
Understanding the intestinal regenerative response using patterned organoids in photo-tunable PEG hydrogels
Project Summary Nonspecific targeting of highly proliferative, non-cancerous cell types during chemotherapy highlights the limitations of these treatment modalities. In the intesti...
Synaptic transmission at retinal ribbon synapses
In sensory cells of the eye and inner ear the neurotransmitter glutamate is released at active zones in a graded and continuous manner. These cells have evolved specialized structu...
Neurogenesis, BMP signaling, and mechanisms of Ketamine's antidepressant effects
Major Depressive Disorder (MDD) is one of the top three causes of disability worldwide, but only 60-70% of patients with MDD respond to first-line therapies, and responders have la...
Inhibitory Network Dynamics Supporting Hippocampal Spatial Representations
Project Abstract The hippocampus is a mammalian brain structure critical for various cognitive functions, including spatial navigation and episodic memory. Hippocampal area CA1, th...