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201,169 grants found
Showing 200,561 – 200,580 of 201,169 grants
Identification of Flavivirus Nucleocapsid Core-Envelope Glycoprotein Interactions
Project Summary/Abstract Flaviviruses (a family of over 90 known viruses, including Zika, dengue and West Nile) are significant human pathogens affecting 3.1 billion people annual...
Investigating the Associations Between Safety Cue Learning and Trauma Exposure in Development
Exposure to trauma throughout the lifespan, and in particular during childhood and adolescence, is prevalent, with more than two-thirds of all children in the United States having...
The role of a Legionella pneumophila gene cluster during infection of mammalian hosts
Project Summary / Abstract Infections caused by intracellular bacteria pose a substantial threat to global health by subverting the immune system to replicate inside host cells. L...
A novel class of long non-coding RNA in regulation of the type I interferonresponse
Project Summary The mammalian genome is pervasively transcribed to generate a complex non-coding transcriptome. A novel class of long non-coding RNA (lncRNA) called DoGs for ?Downs...
Dissecting the role of neural inputs in the regulation of AgRP neurons
Project Abstract: Proper regulation of food intake is essential for survival to prevent over- or under-feeding. Sensory signals generated by the detection and consumption of food c...
Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases
An important question in the field of multiple sclerosis (MS) is whether myelin/axonal damage in the white matter facilitates neuronal cell body loss in the gray matter, or results...
Brachytherapy to achieve in situ cancer vaccination
Project Summary/Abstract We aim to improve the cure rates for metastatic cancers. To achieve this we propose a combined modality approach to stimulate and diversify an endogenous a...
Actin-mediated regulation of organelle dynamics in Charcot-Marie-Tooth disease
Project Summary Organelle dynamics profoundly affect the physiology of the cell and are regulated by interactions with the cytoskeleton. Alterations in organelle dynamics (i.e., i...
Impact of the microbiome on chemotherapeutic outcomes
PROJECT SUMMARY/ABSTRACT Cytotoxic chemotherapeutic agents are a key component of cancer therapy, but they have unpredictable treatment responses and considerable treatment-relate...
International Fluency Association (IFA) Joint World Congress
Project Summary This grant seeks support for graduate student and early career faculty travel to attend the 10th World Congress on Fluency Disorders, to be held July 22-25, 2021 at...
Assessing the Influence of the Human Lipidome on Risk of Diabetes in a Minority Population
PROJECT SUMMARY Type 2 diabetes is a major public health concern. Diabetes currently affects 25.8 million people in the US alone and 90-95% of all cases are type 2. There are many...
Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors
Sialylated glycans are involved in complex regulation and signaling and play a critical role in disease. In the virus life cycle, receptor binding and sialic acid cleavage to facil...
Regulating transcription of the key neural lineage driver ASCL1
The bHLH transcription factor ASCL1 (HASH1/MASH1) is essential for neuronal differentiation and sub-type specification of multiple neuronal cell-types throughout the brain, spinal...
Structural basis of nicotinic acetylcholine receptor gating and toxin inhibition
Nicotinic acetylcholine receptors are therapeutic targets for neurodegenerative disorders, addiction, and mental illness. These pentameric ligand-gated ion channels are prototypica...
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
PROJECT SUMMARY/ABSTRACT Head and Neck Squamous Cell Carcinomas (HNSCCs) are devastating upper airway tumors that are associated with an immunosuppressive network impacting the tum...
Investigating mechanisms underscoring dichotomous T cell responses between medulloblastoma subgroups
PROJECT SUMMARY/ABSTRACT (30 lines of text): Medulloblastomas are one of the most common childhood brain tumors and are comprised of several histological and molecularly distinct s...
Acoustically-driven optical-interferometric microscope for cell characterization
Abstract The goal of this proposal to develop a first of its kind acoustically driven quantitative phase microscopy (QPM) rheology system. Mechanical forces play an important role...
Enterotoxigenic Bacteroides fragilis in modulation of host immunity
PROJECT SUMMARY Humans and other mammals are colonized by a plethora of microorganisms at the time of birth. The constellation of microorganisms that inhabit the gut is key in the...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional select...
Diabetes: Many Faces of the Disease
ABSTRACT Support is requested for a Keystone Symposia conference entitled Diabetes: Many Faces of the Disease, organized by Drs. Lori Sussel, Juleen R. Zierath and Laura C. Alonso....