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201,169 grants found
Showing 200,541 – 200,560 of 201,169 grants
Elucidating the molecular mechanisms underlying ligand-dependent REV-ERB activity in Th17 cells
Project Summary/Abstract Inflammatory bowel diseases (IBD), including Crohn?s disease and ulcerative colitis are characterized by an inappropriate immune response to commensal gut...
Creating natural product diversity via the fabrication of a hybrid fatty acid-nonribosomal peptide synthetase
Abstract: Natural products and derivatives/mimics of natural products make up the majority of modern therapeutic drugs due to their unique complex organic scaffolds that contribute...
Gamma Butyrolactones as Biosynthetic Gene Cluster Inducers
Project Summary/Abstract Historically, natural products (NPs) from Streptomyces have been rich sources for medicines including antibiotics, antifungals, anticancer agents and many...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres?which define and protect the ends of humans? linear chromosomes?serve as a natural check on carcinogenesis. Genome stability requires cells to di...
Associations between ambient temperature and mortality in U.S. state prisons
PROJECT SUMMARY/ABSTRACT There is a growing body of evidence that outdoor ambient temperatures are associated with short-term increases in daily mortality, with greater susceptibil...
Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has been a revolutionary antitumor treatment and is approved to treat a plethora of cancer types. However, in solid tumors the respons...
Investigating the Genetic Basis for Quantitative Autistic Spectrum Disorder (ASD) Traits
Project Summary / Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder defined by social communication deficits and restricted, repetitive behaviors and intere...
IL-1Beta-Induced Retinal Iron Accumulation in Age-Related Macular Degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the United States. AMD is characterized by the death of photoreceptors...
The Consequence of Impaired Lymphatic Drainage on Rejection in Cardiac Transplantation
PROJECT SUMMARY The leading cause of chronic cardiac transplant rejection?coronary artery vasculopathy (CAV)?remains a major factor limiting long-term survival in heart transplant...
Deep learning models to predict primitive streak formation in human development
Project Summary Congenital birth defects affect an estimated 3% of live births. To develop effective treatment strategies, a thorough understanding of early human development is ne...
The Role of dNp63 in Maladaptive Regeneration and Repair Following Severe Pulmonary Injury
Abstract Unlike many mammalian vital organs, the lung exhibits a robust regenerative response to severe injuries such as influenza infection, which primarily targets epithelial cel...
Understanding Intraspecific Diversity of Gardnerella vaginalis in the Vaginal Microbiome
Project Summary Gardnerella vaginalis has been associated with bacterial vaginosis (BV) and preterm birth (PTB) risk, but with little success in being able to identify, treat, and...
Characterizing human-specific expression of ZP2 in the cerebellum
SUMMARY Finding new treatments for neuropsychiatric disorders is a priority, as these disorders affect over 1 in 5 US adults and cost the US health care system over 180 billion do...
Determining the Mechanism of Transformation for Rhabdomyosarcoma
ABSTRACT Rhabdomyosarcoma (RMS) is an aggressive, soft-tissue sarcoma in children. While many clinical trials have worked to improve patient outcomes, the 3-year survival rate for...
Studies of the structural and functional basis of neuroblastoma drug resistance
PROJECT SUMMARY/ABSTRACT Neuroblastoma is the most common extracranial tumor of young children, and the five-year overall survival of children with high-risk disease is less than...
Advancing Ultraviolet Photodissociation Mass Spectrometry for Precision Mapping of Protein Glycosylation
PROJECT SUMMARY Glycosylation plays a structural and functional role in all fundamental features of proteins in cells. Despite substantial evidence suggesting O-glycosylation is vi...
Computational Investigations of the Mechanisms Behind Microtubule Catastrophe
PROJECT SUMMARY Microtubules (MTs) constitute the largest components of the eukaryotic cytoskeleton and facilitate a plethora of diverse functions including intracellular transport...
Determining the role of macrophages in the developing cardiac conduction system
PROJECT SUMMARY/ABSTRACT Macrophages are well-characterized as sentinel immune cells that coordinate cellular responses to injury and infection. However, emerging evidence demonst...
Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memory
PROJECT SUMMARY/ABSTRACT The hippocampus is a critical brain region for various types of learning and memory, and one powerful paradigm to investigate hippocampal function in assoc...
Population-Targeted Risk Prediction to Guide Breast Cancer Screening in Cameroon
Project Summary/Abstract: As cancer becomes an increasingly important cause of mortality in sub-Saharan Africa, nations must improve their capacity to diagnose and treat the malign...