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201,169 grants found
Showing 200,501 – 200,520 of 201,169 grants
Master epigenetic regulators and retinal degenerative disease
Project summary Retinitis pigmentosa (RP) is the leading cause of inherited blindness afflicting one in every 3500 people. There are no effective treatments for RP, and no prospect...
High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
Project Summary Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subseq...
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype
PROJECT SUMMARY Rapid evolutionary adaptation is a foundational process in biology and at the core of many issues facing humanity including cancer, bacterial and viral diseases, ev...
Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial
Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Although several drugs are FDA-approved for the treatment of os...
Investigating novel host factors promoting human papillomavirus infection
Project Summary/Abstract: Human papillomavirus (HPV) infects nearly 80 million U.S. adults, and is the primary cause of cervical, anogenital, and oropharyngeal cancers. Unfortunate...
Defining the role of Mst1/Mst2 in regulating metabolic alterations in Ras driven NSCLC
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) remains the most commonly diagnosed malignancy and leading cause of cancer related deaths worldwide; yet there is a fund...
2020 Pittsburgh International Lung Conference: Metabolism and the Lung: Homeostasis, Immunity, and Disease
ABSTRACT This application requests partial funding for the 2020 Pittsburgh International Lung Conference entitled ?Metabolism and the Lung: Homeostasis, Immunity, and Disease.? The...
Therapeutic Targeting Mitochondrial C1 Metabolism
ABSTRACT Metabolic reprogramming is an important hallmark of cancer. Of the altered metabolic pathways associated with malignancy, one-carbon (C1) metabolism is particularly notabl...
Regulation of Antiviral Responses in Plasmacytoid Dendritic Cells to Chikungunya Virus by the Gut Microbiota
Project Summary Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted alphavirus in the Togaviridae family that causes severe acute and chronic polyarthritis and affects...
Understanding the Regulation and Biological Roles of Peptidoglycan Hydrolases in Staphylococcus aureus
PROJECT SUMMARY/ABSTRACT The leading cause of antibiotic resistance-associated death in the US is the Gram-positive pathogen Staphylococcus aureus. Many antibiotics used to treat S...
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
PROJECT SUMMARY Genome-wide association studies (GWAS) of complex diseases like COPD have identified many genomic regions associated with disease, but the molecular mechanisms by w...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistance...
Silicon Photonic Detection of anti-ABO Antibodies
Summary Problem: Detecting and quantifying Anti-ABO antibodies is essential for some medical procedures, such as whole blood transfusion and ABO-incompatible solid organ transplant...
Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier
Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with...
DEVELOPMENT OF BASELINE GENE EXPRESSION-BASED RESPONSE PREDICTOR FOR ANTI-TNFA THERAPY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES
ABSTRACT Anti-TNF? therapies are widely used to treat autoimmune diseases, including inflammatory bowel disease (IBD), a chronic inflammation of the digestive system which presents...
Novel Immunoregulatory Therapeutics for Systemic Lupus Erythematosus
Novel Immunoregulatory Drugs for Systemic Lupus Erythematosus BioTherapeutics, Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computat...
Rapid identification and selection of functional antigen-specific monoclonal antibodies by FcGR-enabled screening on CytoSort Arrays in the CellRaft AIR System
Project Summary The production of antibodies using hybridoma screens and in vitro screening technologies represents one of the most industrialized processes in contemporary life s...
Building a Toolbox to Study the SARS-CoV-2 Proteome
Project Summary The SARS-CoV-2 virus is currently responsible for the global COVID-19 pandemic. While pharmaceutical companies scramble to develop drugs and vaccines, it is critica...
A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration
Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically,...
Tuning CAR-T cell function
Abstract Chimeric antigen receptors (CAR) expressed by T cells recognize tumor cells via single chains antibodies and activate T cell cytotoxic machinery and costimulation. In clin...