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201,169 grants found
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NON-NUCLEASE BASED GENE EDITING FOR HUTCHINSON-GILFORD PROGERIA
Project Summary There is substantial interest in gene editing as a means to treat human genetic disorders such as Hutchinson- Gilford Progeria Syndrome (HGPS). Much effort has been...
Activity-dependent regulation of Sonic hedgehog signaling incortical astrocytes
PROJECT ABSTRACT Understanding the mechanisms by which the CNS adapts to novel experiences and changing environments is a fundamental goal of neuroscience. Following experience and...
Combined Biomaterial and Neuromodulatory Approach to Promote Axonal Outgrowth and Connections After Cervical SCI
Spinal cord injury (SCI) interrupts connections between the motor cortex (MCX) and spinal motor circuits. We propose a novel approach to treat paralysis and weakness after spinal c...
DNA Topoisomerase Misfunctioning in Neurological Disease
DNA topoisomerase II (Top2) carries out changes in DNA structure needed for efficient transcription, replication, and DNA repair. This enzymes introduce transient double strand bre...
Place-Based Mapping in Electric-Acoustic Stimulation Listeners
Abstract Cochlear implant (CI) recipients with acoustic hearing in the implanted ear are fit with a hearing aid and CI in the same ear, a configuration described as electric-acoust...
Structure-Based Design of Peptide Entry Inhibitors against Ebola Virus Infection
Abstract Ebola viruses (EBOV) along with Marburg viruses (MARV) belong to the Filoviridae family which infects humans and nonhuman primates and causes outbreaks with a high mortali...
Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloading
PROJECT SUMMARY/ABSTRACT We aim to reduce the limb-threatening and life-limiting burden of neuropathic diabetic foot ulcers (DFU) by advancing science in its most critical compone...
Mitigating risk from macroeconomic stress on child mental health: Exploring protective effects of universal preventive intervention
The broad goals of this study are to strengthen our understanding of how social determinants of health, specifically socioeconomic conditions and associated stressors, can be mitig...
Remotely controlled listerial bactodrones for cancer immunotherapy
PROJECT SUMMARY Attenuated and avirulent strains of Listeria monocytogenes (Lm), that are delivered via intravenous injections, accumulate and propagate in primary tumors and metas...
Bcl-2 as a target in cancer
Project Summary Bcl-2, an anti-cell death protein, is overexpressed in about 40% of all human cancers and contributes to the development and progression of cancer. Overexpression o...
Role and regulation of a peptidoglycan synthesis enzyme required for cephalosporin resistance in enterococci
PROJECT SUMMARY/ABSTRACT: Infective endocarditis, a condition in which bacteria grow in a biofilm-like state on the valves of the heart, is a deadly complication of bloodstream inf...
Novel Strategies for Treating Biofilm-Forming Pathogens with Phage Therapy
Project Summary The growing antibiotic resistance problem requires that we urgently develop and test new approaches to controlling bacterial infections. Phage therapy approaches of...
REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students
REACH is an 8-week pipeline summer course for minorities and underrepresented college and high school students interested in careers in neuroscience. Developed, together with Drs....
Targeting antibiotic resistance genes in Vibrio cholerae using a phage-encoded CRISPR-Cas system to improve efficacy of phage prophylaxis
PROJECT SUMMARY The incessant rise of multidrug resistance in bacterial pathogens has created a dire situation that necessitates development of new modalities for preventing and tr...
Traumatic Axonopathy in the CNS as Wallerian degeneration
PROJECT SUMMARY In this application we propose that traumatic axonal injury (TAI) leads to an active axonopathy with the molecular features of Wallerian degeneration and that targe...
Proteomic determinants of response to checkpoint blockade in malignant pleuralmesothelioma
PROJECT SUMMARY / ABSTRACT Malignant pleural mesothelioma (MPM) is a fatal cancer of the lining of the lungs that has defeated standard therapies for decades. Immune checkpoint inh...
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics. It leverages...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury
Sepsis accounts for nearly 50% of acute kidney injury (AKI) in the intensive care unit and significantly impacts mortality. However, therapy for sepsis-associated AKI (SA-AKI) has...
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome
There is increasing recognition of mitochondria as signaling organelles. An important facet of this ?adjunct? mitochondrial function is epigenetic modulation, as exemplified by the...