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201,169 grants found
Showing 200,441 – 200,460 of 201,169 grants
Physiology-driven seizure management post-cardiac arrest
PROJECT SUMMARY/ABSTRACT Dr. Edilberto Amorim is a neurologist with subspecialty training in critical care and epilepsy who aims to employ biomedical technology innovations in brai...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologica...
Examining the effects of retinal cell loss on downstream visual brain areas
Because humans rely heavily on vision to experience the world, diseases of the eye are particularly debilitating in that they have significant adverse effects on patient health and...
Molecular mechanisms of Werner syndrome helicase in genome stability and aging
PROJECT SUMMARY Progeroid syndromes mimic aging at an accelerated rate and are key to understanding both premature and normal aging. One class of progeroid syndromes results from...
Examining the role of the neighborhood environment on muscle function in older adults
PROJECT SUMMARY/ABSTRACT Poor muscle function is a pressing public health problem: half of all U.S. older adults meet criteria for muscle weakness. Poor muscle function, defined by...
MMACHC Regulates Craniofacial Development
cblC is a multiple congenital anomaly syndrome caused by mutations in the MMACHC gene. cblC is characterized by defects in cobalamin (vitamin B12) metabolism, but mild to moderate...
Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill children
Project Abstract Overtreatment ? health care in which the benefit does not outweigh risks ? accounts for up to $200 billion annually in the United States, and is associated with wo...
The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension. More than 17 million Americans consume >20% of their calories as fructose and...
Digital Phenotyping To Screen For Early Childhood Internalizing Disorders
ABSTRACT Childhood anxiety and depression are common, impairing, and have the potential to disrupt development well into adulthood. Pediatricians need mental health screening tools...
Mechanisms of Diabetes and Diabetic Complications in a Multi-Ethnic Population
ABSTRACT Racial and ethnic minority populations bear a disproportionate burden of diabetes and lifetime risk for diabetes-related complications in the United States, yet little is...
Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in TBI
The purpose of this study is to determine whether Acute Intermittent Hypoxia (AIH) is safe to administer to medically stable chronic traumatic brain injury (TBI) patients. There is...
HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES
ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his clinic...
Early Respiratory Care in Amyotrophic Lateral Sclerosis Patients at High Risk for Respiratory Failure
Project Summary/Abstract Respiratory failure commonly occurs in amyotrophic lateral sclerosis (ALS) and leads to significant morbidity and mortality. The onset of respiratory weakn...
Mentoring to Develop Aging-Informed Patient-Oriented Research in Neuropsychiatry
The rising public health burden attributable to brain-based conditions of aging such as cognitive decline/dementia and depression requires more clinicians to provide care and more...
Macrophage Regulation of Immune Pathogenesis of Biliary Atresia
PROJECT SUMMARY: Candidate and Career Development: Dr. Taylor is a pediatric hepatologist and Assistant Professor of Pediatrics at Northwestern University. She has maintained a str...
Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle Relaxation
Project Summary/ Abstract Light-mediated relaxation of smooth muscle has been recently demonstrated. Non-visual opsins expressed on smooth muscle have been implicated as the key m...
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is a major health concern with nearly 2-million new cases of CRC diagnosed worldwide in 2019. While surgical resection of the pr...
Exploring neural crest stem cell-derived enteric neurogenesis in post-embryonic development and regeneration
PROJECT SUMMARY/ABSTRACT I am a gastroenterologist at UCLA, and I am committed to studying enteric neurogenesis to better inform development of therapies for enteric neuropathies...
A New Device to measure Whole and Tissue Level Bone Strength.
Abstract The majority of patients who fracture have non-osteoporotic bone mineral density. Often, the result of a fracture is devastating and results in substantial morbidity and h...
Synaptic mechanisms of auditory thalamic cross-modal communication
ABSTRACT Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and changing cognitive demands. Failure to quickly shift perceptual resources b...