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201,169 grants found
Showing 200,401 – 200,420 of 201,169 grants
Complexity and the Wound Healing Response
Project Summary The ability to heal is essential for human health. The remarkable wound healing capacity of humans (and indeed of all animals) is a complicated process. Genomic stu...
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
Project Summary Many long-term survivors of cancer experience progressive chemotherapy-induced cognitive impairment (CICI, commonly referred to as chemobrain). Importantly, no stra...
cryoEM Studies of Muscle
Project Summary The long term goal of this research project has been and continues to be an understanding of the molecular mechanism of muscle function. The existing project, funde...
Allorecognition, parasitic stem cells and regeneration in a basal chordate
Abstract Our lab works at the intersection of immunology, stem cell biology and regeneration, and the grants funding this work (GM123267 and GM 123255) which we are requesting to m...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively infl...
Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells
PROJECT SUMMARY/ABSTRACT PI: Snow, Andrew L. The healthy immune system depends upon a balance of proliferation and death of white blood cells, including B and T lymphocytes, to co...
Novel population-genetic methods for localizing targets of natural selection in diverse human genomes
PROJECT SUMMARY. The PI's research program in population genetics focuses on the coalescent-based inference of population his- tories from whole genomes, and the determination of g...
Novel Nutrient Functions and Sensing Mechanisms
Project Summary/Abstract Despite its long history, the nutrient biology field is still facing a plethora of outstanding questions closely related to human health, two of which wil...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc b...
Mechanisms of Sex Determination in Zebrafish
The Problem: Differences in (or Disorders of) Sex Development (DSD) are complex medical issues that involve multiple interacting cell types and organ systems. DSDs impact disease s...
Structural and Functional Studies of HER Receptors
PROJECT SUMMARY/ABSTRACT Receptor tyrosine kinases (RTKs) are activated by extracellular ligands to transduce the bulk of the signals that control cellular growth, proliferation an...
Development of Asymmetric Cooperative Gold Catalysis and Beyond
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic metho...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms of...
Molecular and Clinical Glycobiology of the Bone Marrow Environment
The life-long production of blood cells requires hematopoietic developmental programs guided by systemic and local signals to convey the dynamic need for these cells. How these sig...
Core A: Administrative Core
Administrative Core - Project Summary/Abstract The Administrative Core is located within the administrative offices of the Blood Research Institute (BRI), the research arm of Versi...
Core B: Glyco-genomics and Bioinformatics
Core B - Project Summary/Abstract This Program Project will investigate the mechanisms by which glycosylation and glycans may alter the function, maintenance, differentiation, and...
Core C: GAGomics and Proteomics
Core C ? Project Summary/Abstract Glycosaminoglycans (GAGs) are linear O-linked polysaccharides that modify serine residues for a select number of membrane proteins (e.g., glypican...
Project 1: Megakaryocytes as Organizers of the Hematopoietic Environment
Insufficient megakaryopoiesis and thrombopoiesis remain the main cause of persistent thrombocytopenia after hematopoietic stem and progenitor cell (HSPC) transplantation and after...
Project 2: Extracellular Glycosylation and Blood Cell Production
Project 2 ? Project Summary Maintaining hematopoiesis is critical for life. Generating the proper numbers of functional blood cells across all lineages requires cell-intrinsic deve...
Project 3: Role of Glycosaminoglycans in Hematopoiesis
Project 3 ? Project Summary/Abstract Glycosaminoglycans (GAGs) contribute to myriad, and very often opposing, functions such as cellular proliferation as well as apoptosis, self-re...