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44,293 grants found
Showing 141 – 160 of 44,293 grants
Supracellular coordination in tissue morphogenesis
How organ shape is genetically encoded remains a major unresolved question in biology. All tissues arise from simple primordia that become patterned through transcriptional changes...
An international task force to create adaptive bio-psycho-social and environmental models of sleep, circadian rhythms, and youth depression and anxiety across five continents
Sleep and circadian rhythm disturbances (SCRD) play vital roles in the development and maintenance of depression and anxiety, especially during youth, a critical time for early pre...
Adaptive responses to SARS-CoV-2 variants in the context of hybrid immunity and immune impairment
SARS-CoV-2 evolved variants that could escape previous immunity and transmit better. This process so far culminated in the Omicron variant, which led to a global infection wave of...
BEST4: A Platform Trial to determine whether capsule sponge-biomarker technology reduces mortality from oesophageal cancer
This study has joint funding between NIHR HTA and CRUK (total funding is £6m). Oesophageal cancer (OAC) is a poor prognosis cancer, and the current clinical pathways are ineff...
Unravelling the lipid landscape in lysosomal storage disorders and associated Parkinson's disease: insights for drug discovery
Genetic variants in lysosomal sphingolipid (SL) genes cause lysosomal storage disorders (LSDs) and are strongly linked to Parkinson’s disease (PD) risk. In addition to the lysosoma...
Understanding Society Waves 17-19 (Fieldwork Grant 1)
This grant is for the fieldwork costs for waves 17-19 of the main survey and waves 18-20 of the innovation panel of Understanding Society: the UK Household Longitudinal Survey (202...
Modelling human choroid plexus development and the regulation of cerebrospinal fluid in health and disease
Our brain is floating in the cerebrospinal fluid (CSF): a source of signaling factors, hormones and nutrients. The CSF is secreted by a single layer of cells called the choroid ple...
Hydrogen Aggregated UK Logistics (HyHAUL) Project
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because...
VR social cognition therapy in early psychosis: effectiveness and implementation
As well as specific symptom clusters, psychosis effects important non-symptom domains including social cognition and social-occupational functioning. Impaired social cognitive abil...
A single-blind, randomised, phase II UK multi-centre study to determine reactogenicity and immunogenicity of booster vaccination against ancestral and novel variants of SARS-CoV-2 (COV-BOOST)
The 2 vaccines which have been delivered at scale in the UK so far have been the mRNA vaccine BNT162b2 (Pfizer) and the chimpanzee adenovirus vector vaccine ChAdOx1-nCov19 (Oxford/...
Circadian Light Sensitivity as a Mechanism for PTSD Vulnerability
Light regulates circadian rhythms, and unhealthy light exposure patterns have negative impacts on mental health. Disrupted circadian rhythms have been associated with posttraumatic...
REFINE-Lung (formerly known as CONVOLUTE): A randomised open-label phase III trial of REduced Frequency pembrolizumab ImmuNothErapy for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design.
RESEARCH QUESTION: Can pembrolizumab (pembro) dose frequency be reduced without compromising efficacy in advanced non-small cell lung cancer (NSCLC)? BACKGROUND: The anti-PD1 di...
Understanding and breaking the chain of disrupted sleep and mental disorders
Mental disorders will be the number one health burden of our society worldwide in 2030. The top three among these are respectively anxiety disorders, insomnia and depression, toget...
Optimizing the Use of Oral Cholera Vaccine for Enhanced Impact: A Randomized Controlled Trial and Observational Study to Inform Vaccination Strategies in Kenya
Through a comprehensive approach that includes a randomized controlled trial, immunological analysis, and case data analysis in Kenya, our consortium will provide valuable knowledg...
Improving primary care antibiotic prescribing to reduce antibiotic resistant urine infections: the IPAP-UTI programme
Research question The aim is to optimise UK antibiotic prescribing for urinary tract infections (UTIs) in primary care, in response to local antimicrobial resistance (AMR) trends....
NIHR Royal Marsden CRF
The Royal Marsden (RM) has a long tradition of driving and delivering research to change cancer care. This includes research that translates scientific discoveries into new ways of...
The Monoclonal Antibody Medications in inflammatory Arthritis: stopping or continuing in pregnancy (MAMA) trial
Research Question In pregnant women with Autoimmune Inflammatory Arthritis (AIA) (population), does continuing biological disease modifying anti-rheumatic drugs (bDMARDs) (interve...
Birmingham BRC in Inflammation
The Birmingham Biomedical Research Centre (BRC) unites leading NHS and academic institutions in the UK s biggest and most diverse population centre outside London, serving ~5.7mill...
AI UK: Creating an International Ecosystem for Responsible AI Research and Innovation
Artificial Intelligence (AI) can have dramatic effects on industrial sectors and societies (e.g., Generative AI, facial recognition, autonomous vehicles). AI UK will pioneer a refl...
Thromboprophylaxis in Lower Limb Immobilisation (TiLLI): a multicentre study comprising two linked open label phase III randomised controlled trials evaluating the effectiveness and cost effectiveness of different methods of pharmacological prophylaxis for patients with temporary lower limb immobilisation
BACKGROUND Venous thromboembolism (VTE) is a major global health burden. Many people who survive VTE suffer from longer term physical complications or psychological sequelae. Temp...