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Translational regulation of cerebral cortex wiring
The mammalian cerebral cortex is a highly complex brain structure containing a wide diversity of neuronal cell types interconnected in a remarkably specific manner.The many behavio...
Haematopoiesis across Scales, Species and Time: a Foundational Approach to Study Stem Cell Biology and Disease
The full complexity of biological systems can only be unravelled by working across scales.Here we propose to traverse molecular, cellular and organ scales, as well as working acros...
The Mental Health Costs of Statelessness: A case study of Pakistani Bengali Adolescents and Young Adults
The need to belong is a fundamental human motivator, with strong connections to good mental health.Stateless individuals, numbering 15 million globally, fall on the margins and exp...
‘Just who do I leave my worldly possessions to, darling?’: A Study of Queer Inheritance
Inheritance - the right to bequeath one’s estate to whomever one chooses is at the heart of end-of-life wellbeing and a cornerstone of a ‘good death’.This project examines what inh...
Exploring Eco-efficient blended cements: Innovations in performance and sustainability
Europe is committed to achieve the ambitious goal of reducing greenhouse emissions and to transition towards an energy-neutral built environment by 2050.The construction sector, wh...
Continuous glucose monitoring in women with early onset type 2 diabetes in pregnancy
Early-onset type 2 diabetes (EOT2D; onset 70% time-in-range supports healthy pregnancy outcomes. However, there is no evidence for CGM targets to support a healthy pregnancy in EOT...
Optimising fully closed-loop insulin delivery
Hybrid closed-loop systems are increasingly being implemented in clinical care for people with type 1 diabetes.These systems improve glucose control and have quality-of-life benefi...
Photo-rechargeable Zinc-ion Battery for the Internet of Things Working under Ambient Light
By 2025 more than 49 billion Internet of Things (IoTs) are anticipated due to technological breakthroughs and its widespread application in smart homes, smart cities, agriculture,...
Sewer Ecologies: The Hidden Heritage of London's Urban Infrastructure
Thousands of kilometres of tunnels run under the streets of London, keeping waste contained and concealed.London inherited this sewerage system from the Victorians, most notably Ch...
MATIC: Materiality of Imperial Crossings during the age of steam (c. 1850-1950)
The MATIC (Materiality of Imperial Crossings during the age of steam, c. 1850-1950) project aims to deepen our understanding of modern colonial empires by exploring the material cu...
Asymmetric DNA-based OrganoCatalysis
Asymmetric catalysis is arguable the most appealing way to prepare complex chiral scaffolds. In this context, metal-catalyzed transformations have been more widely used in comparis...
AI-BRIDGES: AI-Driven Bridging of Resources and Integration of Data Governance in Cultural Heritage Systems
AI-BRIDGES: Enhancing Cultural Heritage Impact through Generative AI and Linked Open DataAI-BRIDGES addresses the disconnect between Cultural Heritage Institutions (CHIs), Linked O...
3d-printed structural joint details for sustainability and robustness in steel frames
The construction industry needs optimal solutions to meet sustainability goals, reduce carbon emission, decrease materialconsumption and improve the speed of construction. In addit...
Exploring a Dehydrating/condensation enzyme Domain for a Diversified Antimicrobial Peptide Library
Peptides found in nature, such as penicillin, are a vital source of the antibiotics used to combat infections.While many of these peptides possess useful antimicrobial properties,...
Cable-driven Arm Soft Re-configurable Exoskeleton for Muscle Impairment Rehabilitation
Upper limb muscles wrap around bones to aid Activities of Daily Living (ADLs) like eating, enhances leverage and joint stability.Conditions like stroke, along with an aging populat...
Universality Classes for Strongly Correlated Random Fields
The objective of this project is to develop the mathematical theory of critical phenomena.In spite of recent breakthroughs, second-order phase transitions have remained largely elu...
Feeding the Roman Army, Making the Empire
FRAME capitalises on advances in archaeological science and a critical mass of archaeological material to examine how the Roman Empire’s frontiers in Europe functioned as economic...
Mutations in healthy tissues: a double-edged sword for tissues homeostasis
Healthy tissues become progressively populated of clonally expanded cells that have acquired somatic mutations.Often these mutations modify cancer genes promoting cell plasticity,...
Geometric approach to many-body quantum chaos
Quantum chaotic dynamics is in the focus of many current developments in physics, ranging from thermalisation in closed quantum systems to the black hole information puzzle.Recentl...
Actually Existing Development: Twentieth Century International Development and the Global South
International developmentthe cross-border transfer of funds and expertise for developmental purposesformed a core plank of the twentieth century international system. But we still...