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44,293 grants found
Showing 741 – 760 of 44,293 grants
Rest Or Moderate Mechanical Ventilation During ECMO Support - ROMEO
Research question: What is the clinical efficacy of near apnoeic ventilation (NAV) with two sigh breaths per minute after initiation of extracorporeal membrane oxygenation (ECMO) f...
LACunar Intervention (LACI) Trial-3: Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke
Research question: Do oral isosorbide mononitrate (ISMN) and/or cilostazol, prevent cognitive impairment, dependency, adverse vascular outcomes, death, and improve quality of life,...
Spatial Inattention Grasping Therapy (SIGHT) for rehabilitation of spatial neglect post-stroke: a randomised-controlled multicentre efficacy trial with embedded mechanistic study of determinants of therapy response
Research question: Is SIGHT more efficacious than usual care in reducing spatial neglect in stroke, and what determines therapy response? Background: The James Lind Alliance and N...
Biomarkers for RAtional Investigation for Neurological decision Support in TBI: BRaINS-TBI
In the UK ~1 million people attend emergency departments (ED) annually with mild traumatic brain injury (mTBI). The focus in an ED is to evaluate the requirement for a CT brain sca...
REFRESH study: nutRition intervEntions For malnouRished oldEr adultS in care Homes - A parallel, superiority, three-arm cluster randomised controlled trial.
Research question In older adults with or at risk of malnutrition living in care homes, what is the clinical- and cost-effectiveness of oral nutritional supplements (ONS) and fort...
A pragmatic randomised trial comparing Oral Corticosteroids and Colchicine for the treatment of goUt flaRes in people with relative contraindications to non-steroidal anti-inflammatory drugs (the OCCUR trial)
Research question: What is the clinical and cost-effectiveness of oral prednisolone versus colchicine in people currently experiencing a gout flare who have relative contraindicati...
A randomised trial of aminophylline, magnesium sulfate or salbutamol intravenous therapy for acute severe asthma in children and young people.
RESEARCH QUESTION: What is the clinical effectiveness and cost-effectiveness of intravenous (IV) bronchodilators in children and young people (CYP) with severe acute asthma unrespo...
Integrated models of community service delivery for children and young people in coastal regions of England: A Realist evaluation
Research question What integrated community service models (ICSMs) work best for children and young people (CYP) living in deprived coastal communities of England, under what circ...
HEaLth iMpact of E-bikes and e-scooTers (HELMET)
Regular physical activity helps to prevent a range of chronic diseases and reduces all-cause mortality. Increased active travel has been associated with higher overall physical act...
Treatment of Toddlers Fractures: Observation Or Immobilisation (TOTs)
Research Question: In children aged 9 months to 3 years diagnosed with a toddler's fracture, is no immobilisation non-inferior to immobilisation with respect to pain scores measure...
Enabling equity for minority ethnic unpaid and family carers: Cultural acceptability of the Carer Support Needs Assessment Tool Intervention and Methods for Evaluation
Background Unpaid carers provide practical or emotional support to dependents with long-term and life-threatening illnesses who cannot manage without help. Carers have support nee...
A Randomised Multiple Centre Trial of Conservative versus Liberal Fluid administration for Children Receiving a Kidney Transplant (LIMITS)
BACKGROUND In current practice, large fluid volumes are administered to most children following kidney transplant (median > 4 x typical intravenous fluid prescriptions). Up to 52%...
Single and Safe Intervention for MEDication administration (SaSI-MEDs): The development and evaluation of an intervention to de-implement unnecessary double-checking of medicines in hospital
Medication errors are one of the most ubiquitous patient safety problems in modern healthcare, with 237 million errors occurring annually in England. Errors at the point of adminis...
Development of new methodology to frame and address the impact of poor-quality studies on meta-analysis
Background Meta-analysis of randomised clinical trial is used to summarise the effects of healthcare interventions. Since trials are not conducted with equal rigour, an assessmen...
HOW DO WE DEVELOP MEANINGFUL STRATEGIC PUBLIC PARTNERSHIPS?Subtitle: “Becoming neither fish nor fowl...”
HOW DO WE DEVELOP MEANINGFUL STRATEGIC PUBLIC PARTNERSHIPS?Subtitle: “Becoming neither fish nor fowl...”
The Peer Mental Health Network: Connections to advance culturally inclusive mental health intervention for minority ethnic people living with long-term conditions
The Peer Mental Health Network: Connections to advance culturally inclusive mental health intervention for minority ethnic people living with long-term conditions
Development work for an evaluation of a complex intervention to increase uptake of vaccinations in pregnancy among socio-economically and ethnically diverse populations
Development work questions: Can an intervention designed to address user, provider and systemic barriers to vaccination be co-developed with pregnant women/people, those plannin...
Family Interventions iN Dementia Mental health Environments (FIND ME)
Aims: To understand carer experiences when a person with dementia is detained within a mental health ward, and staff rationales and responses to carers. The goal is to develop co-d...
Swept under the carpet!" Let's talk about sex, periods and having babies
Swept under the carpet!" Let's talk about sex, periods and having babies
Exploring the Soteria approach as an alternative to psychiatric inpatient treatment in the UK
Exploring the Soteria approach as an alternative to psychiatric inpatient treatment in the UK