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44,293 grants found
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Genetic contribution to multi-system, multi-organ atopic disease
Atopic dermatitis (AD) is a chronic inflammatory skin condition that significantly impacts quality of life. It is often complicated by other atopic disorders such as asthma, allerg...
RECENTRE (undeRstanding EpidemiCs in prEgnaNt and lacTating people and infants: an inteRdisciplinary nEtwork)
I plan to establish a leading interdisciplinary research network in (re)emerging infections in pregnant/lactating people and infants, groups with distinct vulnerabilities during ep...
Linuron effects on human fetal ovary development
As I aspire to lead my own research group investigating the effects of environmental factors on human fetal development, I need to build towards competitive independence for a tenu...
Shared decision making in assessment and management of risk with individuals living with severe mental illness: a career and research programme development proposal
In mental health services, assessing and managing risk is important in providing safe and effective care. These processes should involve collaboration and Shared Decision-Making (S...
Cancer diagnosis in people with disability: a multi-methods international project on diagnostic pathways and cancer outcomes
Background Under the UK Equality Act 2010, a disabled person is "someone who has a physical or mental impairment that has a 'substantial' and 'long-term' negative effect on their a...
MicrobeScope: Innovating advanced, locally sustainable bioimaging technology for infectious disease research in disease-endemic settings in Africa
Initiatives aimed at overcoming barriers to the use of bioimaging in low- resource settings tend to focus on access to instruments, training, and networking opportunities. Despite...
To live or Die: Dissecting the role of Liquid- Liquid Phase Separation in Membrane Protein Triage.
Correct protein localisation is vital for cell function and health. However, the sorting process is not always efficient, with failure rates of 5-10% for endoplasmic reticulum (ER)...
Environmentally Sustainable HeAlth REsearch (SHARE): from ‘tool solutionism’ to a context sensitive, just, systems-focused and reflexive approach
Health research is implicated in a range of harmful environmental impacts such as energy and other resource consumption and plastic use and other waste generation. Numerous tools h...
Exploiting the radiobiological potential of protons and high-LET radiation
The strategic focus of the proposed Birmingham RadNet Centre (BRNC) is to explore the radiobiological impact of protons and high linear energy transfer (LET) radiation at the molec...
The use of high-throughput blood-based metabolomics for ovarian cancer early detection and diagnosis
Background: Ovarian cancer, a leading cause of gynaecological cancer-related mortality, poses significant challenges due to its late diagnosis and lack of effective preventative st...
Identifying the mechanisms responsible for low- to high-grade transformation in IDH mutant astrocytoma
Background: IDH mutant (IDHmut) astrocytoma is an incurable brain cancer that typically presents as a low-grade lesion but high-grade transformation occurs uniformly, after which a...
Hyperactive complement driving inflam-ageing: a shortcut to cancer?
Background: We have developed a sophisticated complement C3 gain-of-function (GOF, C3D1115N/D1115N, or C3N/N) knock-in mouse. C3N/N mice develop the rare but devastating kidney dis...
Harnessing radiation biology to increase cancer cure rates
Radiotherapy remains a central pillar of cancer care, contributing to 50% of all cures and improving quality-of-life in many with incurable disease. The reasons why radiotherapy do...
A Randomised Controlled Trial of Renin-Angiotensin System Inhibition for Reduction of Cardiovascular Events after Takotsubo Cardiomyopathy (EVEREST)
1) Research question. Does renin-angiotensin system inhibition (RAS inhibition) reduce recurrent cardiovascular events and improve quality of life in patients after acute takotsubo...
DIRECT: Delivery and Implementation of a Randomised Cluster Crossover Trial on Thrombosis
NICE RESEARCH PRIORITY What is the clinical and cost effectiveness of aspirin alone versus other pharmacological strategies for people with fragility fractures of the hip? BACK...
Understanding the support needs of African and African-Caribbean people living with dementia, their care partners and families and the impacts of delayed support: identifying inclusive strategies to facilitate timely and culturally appropriate social care support.
Aims To understand the experiences of African and African Caribbean people living with dementia (AAC PLWD) seeking support from Adult Social Care. Our goal is to improve how servi...
Understanding and improving compound pressures in general practice: a realist review, appreciative inquiry, and three embedded studies within a review
Project aim: to conduct a realist appreciative inquiry (AppI) and realist review about compound pressures (CP) affecting general practice and the delivery of effective and equitabl...
What makes health checks acceptable and implementable in primary care for people with a learning disability and for autistic people?
What makes health checks acceptable and implementable for people with a learning disability and/or autistic people? Background People with a learning disability and/or autistic p...
Supporting the mental health and wellbeing of mothers at risk of recurrent care proceedings: a realist synthesis
Research question: What works to support the mental health and wellbeing of mothers at risk of recurrent care proceedings, and to prevent care entry of their children? Backgroun...
Paediatric Intensive Care Adaptive Platform Trial (PIVOTAL)
RESEARCH QUESTION: In critically ill children [Population] is/are A) a strategy of conservative fluid management, B) alpha2-agonists as first-line agents for sedation, or C...